Long non‑coding RNA GAS5 in human cancer (Review)

Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong; Gan, Runliang

doi:10.3892/ol.2020.11809

Cited by 80 publications

(57 citation statements)

References 77 publications

(121 reference statements)

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“…Studies have found that lncRNA expression may be functionally associated with drug resistance in acute leukemias [ 68 , 80 , 89 , 104 ]. For example, the lncRNA growth arrest-specific transcript 5 (GAS5) is downregulated in many cancers and may be used as a potential marker of treatment response in remission induction therapy for children with ALL [ 81 , 82 , 105 ].…”

Section: Long Non-coding Rnas In Progenitor B-cell Acute Lymphoblamentioning

confidence: 99%

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

Rodriguez

Paculova

Kogut

et al. 2021

IJMS

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Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding RNA expression across different types of human cancers. Through comprehensive RNA-Seq profiling, a growing number of studies demonstrate that ncRNAs, including long non-coding RNA (lncRNAs) and microRNAs (miRNA), play central roles in progenitor B-cell acute lymphoblastic leukemia (B-ALL) pathogenesis. Furthermore, due to their central roles in cellular homeostasis and their potential as biomarkers, the study of ncRNAs continues to provide new insight into the molecular mechanisms of B-ALL. This article reviews the ncRNA signatures reported for all B-ALL subtypes, focusing on technological developments in transcriptome profiling and recently discovered examples of ncRNAs with biologic and therapeutic relevance in B-ALL.

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Section: Long Non-coding Rnas In Progenitor B-cell Acute Lymphoblamentioning

confidence: 99%

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

Rodriguez

Paculova

Kogut

et al. 2021

IJMS

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show abstract

“…On the other hand, in the long-term perspective, metabolic disorders could be reflected in premature events, and be marked on the genome as methylated genes, as for example in infancy. These findings indicate that GAS5 manifests multifaceted roles in various physiological processes, including tumor ontogenesis [ 19 ]. GAS5 acts as a gene regulatory element through three basic modes of action.…”

Section: The Long Non-coding Rna Repressor Gas5mentioning

confidence: 99%

The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance

Lambrou

Hatziagapiou

Zaravinos

2020

IJMS

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The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that GAS5 acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. GAS5 seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance.

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“…Studies have found that lncRNA expression may be functionally associated with drug resistance in acute leukemias [68,80,89,104]. For example, the lncRNA growth arrest-specific transcript 5 (GAS5) is downregulated in many cancers and may be used as a potential marker of treatment response in remission induction therapy for children with ALL [81,82,105].…”

Section: Notable Case: Lncrna Gas5 and Its Connection To Glucocorticomentioning

confidence: 99%

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

Rodriguez¹,

Paculova²,

Kogut³

et al. 2021

Preprint

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Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding RNA expression across different types of human cancers. Through comprehensive RNA-Seq profiling, a growing number of studies demonstrate that ncRNAs, including long non-coding RNA (lncRNAs) and microRNAs (miRNA), play central roles in progenitor B-cell Acute Lymphoblastic Leukemia (B-ALL) pathogenesis. Furthermore, due to their central roles in cellular homeostasis and their potential as biomarkers, the study of ncRNAs continues to provide new insight into the molecular mechanisms of B-ALL. This article reviews the ncRNA signatures reported for all B-ALL subtypes, focusing on technological developments in transcriptome profiling and recently discovered examples of ncRNAs with biologic and therapeutic relevance in B-ALL.

show abstract

Long non‑coding RNA GAS5 in human cancer (Review)

Cited by 80 publications

References 77 publications

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

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