2020
DOI: 10.3390/ijms21207633
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Abstract: The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance… Show more

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Cited by 28 publications
(20 citation statements)
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“…Alterations in the mTOR pathway have been implicated in leukemogenesis [ 114 ]. Furthermore, GAS5 may mediate regulatory interactions of miRNAs and target mRNAs involved in drug responses (reviewed in [ 115 ]), including miR-222 in leukemia cells [ 116 ]. Together these studies highlight GAS5 as an important lncRNA whose structure influences glucocorticoid drug responsiveness and essential pathways important for cell survival and growth.…”
Section: Long Non-coding Rnas In Progenitor B-cell Acute Lymphoblamentioning
confidence: 99%
“…Alterations in the mTOR pathway have been implicated in leukemogenesis [ 114 ]. Furthermore, GAS5 may mediate regulatory interactions of miRNAs and target mRNAs involved in drug responses (reviewed in [ 115 ]), including miR-222 in leukemia cells [ 116 ]. Together these studies highlight GAS5 as an important lncRNA whose structure influences glucocorticoid drug responsiveness and essential pathways important for cell survival and growth.…”
Section: Long Non-coding Rnas In Progenitor B-cell Acute Lymphoblamentioning
confidence: 99%
“…In recent years, more and more lncRNAs have been found to be involved in regulation of tumorigenesis and cancer development [ 10 ]. Reportedly, GAS5 is abnormally expressed in leukemia, cervical cancer, breast cancer, ovarian cancer, prostate cancer, bladder cancer, gastric cancer, colorectal cancer, liver cancer, osteosarcoma, glioma and lung cancer, and it exerts a tumor-suppressive effect in cancers [ 11 , 12 ]. For instance, in colorectal cancer, GAS5 blocks disease progression through inducing YAP phosphorylation and degradation [ 13 ].…”
Section: Discussionmentioning
confidence: 99%
“…For the first time, Wang et al [ 141 ] revealed that the lncRNA growth arrest-specific 5 (GAS5) was downregulated in bladder cancer (BC) cells and human tissues. GAS5 plays an essential role in cycle arrest, apoptosis, and regulation of cancer cell survival and is located on chromosome 1q25.1 [ 199 ]. Moreover, GA is the positive regulator of GAS5 by upregulation of miR-101, and downregulation of EZH2 could promote apoptosis and decrease BC cells’ viability [ 141 ].…”
Section: Phytochemicals As Antitumor Agents By Targeting Lncrnasmentioning
confidence: 99%