Loneliness in late-life depression: structural and functional connectivity during affective processing

Wong, Nichol M.L.; Liu, H. L.; Lin, Chia Wei; Huang, Chih-Mao; Wai, Yau‐Yau; Lee, S. H.; Lee, T. M.C.

doi:10.1017/s0033291716001033

Cited by 50 publications

(47 citation statements)

References 74 publications

(92 reference statements)

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“…Individuals who were both lonely and isolated showed more apparent brain aging relative to controls, while the difference was not statistically significant for any other group. Loneliness has previously been associated with brain characteristics including smaller regional gray matter volume [47,48,49], as well as changes in structural and functional network connectivity [50,51]. While these brain characteristics are involved in both normal aging and AD pathogenesis [52,53], there are few studies addressing the associations between loneliness and brain aging, as well as known risk factors for adverse health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study

Lange¹,

Kaufmann²,

Ds³

et al. 2020

Preprint

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Amidst the global COVID-19 pandemic, there is an urgent need for establishing knowledge about risk factors for adverse health outcomes associated with loneliness and social isolation. In this study, we show that self-perceived loneliness coincides with objective measures of social isolation as well as the personality trait neuroticism, and that these comorbidities contribute to differential associations with risk factors including depression, social deprivation, unhealthy lifestyle behaviors, cardiovascular risk, and aging of the brain. The findings contribute to identifying groups of individuals who may be vulnerable to loneliness and associated health problems, and emphasize the need for public-health initiatives addressing socioeconomic conditions as well as social, mental, and physical health to reduce the risk of loneliness and adverse health outcomes in the population.

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Section: Discussionmentioning

confidence: 99%

Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study

Lange¹,

Kaufmann²,

Ds³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Clinicians and institutions that are dealing with the elderly have shown a growing concern about its consequences, including profound depressive feelings. Cacioppo et al ( 2006 ) observed that loneliness is associated with strong negative feelings, and other researchers have shown that it impairs self-regulation (Baumeister et al, 2005 ) or that “[l]onely adults have poor emotion regulation and are less likely to use positive feelings to alleviate their negative mood” (Wong et al, 2016 , p. 2487). Loneliness, anxiety, and depressive symptoms may contribute synergistically to a significant decrease in levels of well-being (Liu and Guo, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Loneliness, Resilience, Mental Health, and Quality of Life in Old Age: A Structural Equation Model

et al. 2017

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Objectives: In the scientific literature on aging, a recent core issue has been the role of individuals' internal and external resources, which are considered intrinsically connected, in contributing synergistically to physical and psychological quality of life (QoL). The current study investigates the way in which psychological factors—such as, loneliness, resilience, and mental states, in terms of depression and anxiety symptoms—affect the perceived QoL among elderly individuals.Method: Data from 290 elderly Italian participants were used to study the mediation effects of both mental health and resilience to elucidate the relationship between loneliness and psychophysical QoL.Results: The best model we obtained supports the mediation effect of both resilience and mental health between loneliness and mental and physical QoL. These results highlight that loneliness influences mental and physical QoL via two pathways, with the impact of loneliness mediated by mental health and resilience dimensions.Conclusions: The findings suggest the importance of the support that elderly people receive from social relationships. In terms of clinical interventions, the reduction of loneliness could be an important factor in primary prevention or the recovery process. A way to reduce levels of mental distress could be represented by the increasing of resilience and self-efficacy and reduction of loneliness dissatisfaction. A high degree of resiliency contributes to increasing perceived life quality at the physical and psychological levels, and at the same time, reducing anxiety and depressive symptoms.

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“…The research has repeatedly shown positive association between loneliness and depressive symptoms (Barg et al, 2006;Cacioppo, Hughes, Waite, Hawkley, & Thisted, 2006;Luo, Hawkley, Waite, & Cacioppo, 2012). Loneliness is also associated with activations of areas in the brain that are related to affective processing and as such, plays a meaningful role in late-life depression (Wong et al, 2016). There is a scarcity of studies on the mechanisms underlying the perceived loneliness-depressive symptoms relationship that address issues other than related risks and protective factors.…”

Section: Introductionmentioning

confidence: 99%

The mediating role of hardiness in the relationship between perceived loneliness and depressive symptoms among older

Lee

2019

Aging & Mental Health

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Introduction: Perceived loneliness and depression are risk factors threatening mental well-being of older people. Yet, hardiness, a modifiable internal resource that supports functional resilience, may enhance the capacity of adjusting to challenges arising from age-related physical and psychosocial changes. Hence, hardiness can be a protective factor of mental health. This study examined the role of hardiness in the relationship between perceived loneliness and depressive symptoms among older people in Hong Kong. Methods: 424 Cantonese-speaking Chinese participants, aged 60 years or above, completed a selfreported questionnaire set related to perceived loneliness, hardiness, and depressive symptoms. Structural equation modeling was used to test the proposed model. Results: Results revealed that hardiness partially mediated the positive association between perceived loneliness and depressive symptoms [b ¼ .18, p < .001, BC 95% CI (.10, .27)] with good data-model fit [v 2 (32) ¼ 36.34, p ¼ .27; CFI ¼ .998; TLI ¼ .997; RMSEA ¼ .018; SRMR ¼ .022]. Conclusion: Older people with higher level of perceived loneliness reported less hardiness. Lower levels of hardiness, in turn, correlated with increased self-reported depressive symptoms. The potential benefits of hardiness for promoting mental health of older people was discussed.

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Loneliness in late-life depression: structural and functional connectivity during affective processing

Cited by 50 publications

References 74 publications

Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study

Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study

Loneliness, Resilience, Mental Health, and Quality of Life in Old Age: A Structural Equation Model

The mediating role of hardiness in the relationship between perceived loneliness and depressive symptoms among older

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