Löffler's Syndrome Secondary to Crack Cocaine

Nadeem, Sabha; Nasir, Nadeem; Israel, Robert H.

doi:10.1378/chest.105.5.1599

Cited by 31 publications

(9 citation statements)

References 5 publications

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“…Though these medications are the most commonly associated triggers, the list of medications causing pulmonary eosinophilia is lengthy, and all medications should be reviewed carefully whenever eosinophilia with pulmonary infiltrates occurs. Furthermore, environmental exposures, such as particulate metal exposure and scorpion stings, as well as inhalational drugs of abuse, such as crack cocaine, may lead to eosinophilic pulmonary infiltrates (119,166,167). The presentation of affected patients may vary, from no symptoms to mild respiratory symptoms and cough to a presentation resembling acute eosinophilic pneumonia in severe cases.…”

Section: Drugs/toxinsmentioning

confidence: 99%

Eosinophilic Pneumonias

2012

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SUMMARY This review starts with discussions of several infectious causes of eosinophilic pneumonia, which are almost exclusively parasitic in nature. Pulmonary infections due specifically to Ascaris , hookworms, Strongyloides , Paragonimus , filariasis, and Toxocara are considered in detail. The discussion then moves to noninfectious causes of eosinophilic pulmonary infiltration, including allergic sensitization to Aspergillus , acute and chronic eosinophilic pneumonias, Churg-Strauss syndrome, hypereosinophilic syndromes, and pulmonary eosinophilia due to exposure to specific medications or toxins.

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Section: Drugs/toxinsmentioning

confidence: 99%

Eosinophilic Pneumonias

2012

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“…Buna karşılık toz formu olan kokain hidroklorür ısıya dayanıksızdır, tütün şeklinde içilemez ve genellikle burundan çekilerek ya da damar yoluyla alınır. 5 Kokain kullanımına bağlı gelişen serebrovasküler problemler; kokain kullanımının neden olduğu davranışsal etkiler ile meydana gelen, kaza ya da kaza dışı nedenlerden kaynaklanan kraniyal travmaların yanı sıra, intrakraniyal hemoraji (İKH), iskemik strok, serebral vaskülit, PRES, serebral ödem, serebral atrofi ve merkezi sinir sistemi (MSS) enfeksiyonu gibi geniş bir spektruma hâkim nöro-lojik komplikasyonları içermektedir. 6 Bilgisayarlı tomografi (BT), manyetik rezonans görüntüleme (MRG) ve konvansiyonel anjiyografi gibi tanısal görüntüleme yöntemlerinin, kokaine bağlı gelişen nörolojik komplikasyonların saptanmasında potansiyel olarak önemli bir rol oynayabileceği düşünül-mektedir.…”

Section: Kokain Kullanımına Bağlı Gelişenunclassified

Neurological Complications of Cocaine Abuse: Updated Review of Radiologic Findings

Şafak¹

2015

Turkiye Klinikleri J Neur

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“…Eur Respir J., 1996, 9, 175-177 Various lung diseases related to the use of freebase cocaine have been reported [1,2]. Pulmonary infiltration with eosinophilia is an uncommon presentation of cocaine smoking [3][4][5][6]. We report a case of Churg-Strauss vasculitis in a patient whose clinical symptoms were clearly related to cocaine smoking.…”

mentioning

confidence: 91%

“…Pulmonary infiltration with eosinophilia is an uncommon presentation of cocaine smoking [3][4][5][6]. We report a case of Churg-Strauss vasculitis in a patient whose clinical symptoms were clearly related to cocaine smoking.…”

mentioning

confidence: 91%

Cocaine-induced Churg-Strauss vasculitis

Orriols¹,

Muñoz²,

Ferrer³

et al. 1996

Eur Respir J

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A freebase cocaine-smoking woman developed relapsing fever, bronchoconstriction, arthralgias and weight loss. Pulmonary infiltrates, arthritis, microhaematuria, pruriginous skin rash and mononeuritis multiplex were later added to the clinical picture. Both skin and muscle biopsies showed eosinophilic angiitis. Improvement or worsening of her clinical picture repeatedly coincided with avoidance or use of smoked cocaine, respectively.We suggest that Churg-Strauss vasculitis may be a complication of smoking freebase cocaine. Eur Respir J., 1996, 9, 175-177 Various lung diseases related to the use of freebase cocaine have been reported [1,2]. Pulmonary infiltration with eosinophilia is an uncommon presentation of cocaine smoking [3][4][5][6]. We report a case of Churg-Strauss vasculitis in a patient whose clinical symptoms were clearly related to cocaine smoking. To our knowledge, this effect of cocaine abuse has not been described previously. Case reportA 39 year old woman had been a 40 cigarette·day -1 smoker since the age of 16 yrs. She had been using cocaine for the last 14 yrs and denied other toxic exposures and i.v. drug abuse. Her initial cocaine use had been limited to intranasal administration. Since then, she had occasionally suffered from wheezing which remitted with the inhalation of adrenergic β 2 -agonists. She had begun to use freebase "smoked" cocaine 8 months earlier. Shortly afterwards, she presented with dyspnoea on effort, wheezing, 20 kg weight loss and polyarthralgias. The patient was admitted because of sweats, 38˚C fever, dry cough and right pleuritic pain of 1 week's duration.Physical examination showed right inspiratory crackles and diffuse expiratory wheezes. Nasal examination was normal. Chest radiography disclosed an alveolar infiltrate in the right lower lobe. Electrocardiography (ECG) revealed tachycardia at 110 beats·min -1 with diffuse repolarization changes. Pulmonary function testing showed a forced vital capacity (FVC) of 2.6 L (79% of predicted) forced expiratory volume in one second (FEV1) 2.0 L (70% pred) and FEV1/FVC 77%. Arterial blood gas measurements performed with the patient breathing room air were: pH 7.42; arterial carbon dioxide tension (Pa,CO 2 ) 5.6 kPa (42 mmHg) and arterial oxygen tension (Pa,O 2 ) 6.9 kPa (52 mmHg). Leucocyte count was 11.9×10 9 cells·L -1 with 3% eosinophils, and serum immunoglobulin E (IgE) was 346 IU·mL -1 . Erythrocyte sedimentation rate (ESR) was 99 mm·h -1 . All bacteriological studies were negative. Testing for human immunodeficiency virus was also negative.The patient stopped smoking cocaine and was treated with bronchodilators and antibiotics. Marked clinical and radiological improvement was observed within a few days and the patient was discharged. Temporal relationship between cocaine exposure and laboratory data is shown in figure 1.Six months later, the patient began to smoke cocaine again and presented with three episodes of fever, cough, wheezing, arthralgias and peripheral lung infiltrates ( fig. 2),

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Löffler's Syndrome Secondary to Crack Cocaine

Cited by 31 publications

References 5 publications

Eosinophilic Pneumonias

Eosinophilic Pneumonias

Neurological Complications of Cocaine Abuse: Updated Review of Radiologic Findings

Cocaine-induced Churg-Strauss vasculitis

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