Loco-regional radiosensitizing nanoparticles-in-gel augments head and neck cancer chemoradiotherapy

Bhardwaj, Prateek; Gota, Vikram; Vishwakarma, Komal; Pai, V. R.; Chaudhari, Pradip; Mohanty, Bhabani; Thorat, Rahul; Yadav, Subhash; Gurjar, Murari; Goda, Jayant Sastri; Banerjee, Rinti

doi:10.1016/j.jconrel.2022.01.040

Cited by 10 publications

(10 citation statements)

References 46 publications

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“…Last year, two more publications showed the potential of nanoparticles as radiosensitizers for HNSCC. However, it should be noted that these were not iron oxide nanoparticles and that they were not pure nanoparticles but nanoparticle formulations, so that, in contrast to our study, the radiation-enhancing property cannot be solely attributed to the nanoparticles [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 60%

In Vitro Analysis of Superparamagnetic Iron Oxide Nanoparticles Coated with APTES as Possible Radiosensitizers for HNSCC Cells

et al. 2023

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Superparamagnetic iron nanoparticles (SPION) are being investigated for many purposes, e.g., for the amplification of ionizing radiation and for the targeted application of therapeutics. Therefore, we investigated SPIONs coated with (3-Aminopropyle)-Triethoxysilane (SPION-APTES) for their influence on different head and neck squamous cell carcinoma (HNSCC) cell lines, as well as for their suitability as a radiosensitizer. We used 24-well microscopy and immunofluorescence microscopy for cell observation, growth curves to determine cytostatic effects, and colony formation assays to determine cytotoxicity. We found that the APTES-SPIONs were very well taken up by the HNSCC cells. They generally have a low cytotoxic effect, showing no significant difference in clonogenic survival between the control group and cells treated with 20 µg Fe/mL (p > 0.25) for all cell lines. They have a cytostatic effect on some cell lines cells (e.g., Cal33) that is visible across different radiation doses (1, 2, 8 Gy, p = 0.05). In Cal33, e.g., SPION-APTES raised the doubling time at 2 Gy from 24.53 h to 41.64 h. Importantly, these findings vary notably between the cell lines. However, they do not significantly alter the radiation effect: only one out of eight cell lines treated with SPION-APTES showed a significantly reduced clonogenic survival after ionizing radiation with 2 Gy, and only two showed significantly reduced doubling times. Thus, although the APTES-SPIONs do not qualify as a radiosensitizer, we were still able to vividly demonstrate and analyze the effect that the APTES-SPIONs have on various cell lines as a contribution to further functionalization.

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Section: Introductionmentioning

confidence: 60%

In Vitro Analysis of Superparamagnetic Iron Oxide Nanoparticles Coated with APTES as Possible Radiosensitizers for HNSCC Cells

et al. 2023

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“…A novel nanocarriers-in-ion-triggered mucoadhesive hydrogel has been prepared to enhance site-specific delivery of clinically relevant radiosensitizers i.e., cisplatin and paclitaxel. The nanoparticles released from hydrogel enhanced the tumor bioaccumulation of chemotherapeutic drugs with reducing systemic absorption, resulting in improvement of efficacy and safety confirmed by PET-CT imaging263 .…”

mentioning

confidence: 89%

“…The nanoparticles released from the hydrogel enhanced the tumor bioaccumulation of chemotherapeutic drugs with reduced systemic absorption, resulting in improvement of efficacy and safety confirmed by PET-CT imaging. 263…”

Section: Treatment Of Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Hydrogels for the treatment of oral and maxillofacial diseases: current research, challenges, and future directions

Huang

LIU

et al. 2022

Biomater. Sci.

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“…The hydrogel exhibited sustained tumor bioaccumulation of both anticancer drugs with lower systemic absorption (Figure 8). [276] Tan et al integrated metal-organic frameworks (MOFs) with thermosensitive hydrogel PLGA-PEG-PLGA to generate an injectable system for sustained release of DOX and celecoxib (Cel). The study demonstrated that DOX/Cel/MOFs@Gel had great drug-loading capacity, controlled pH-responsive [276] Copyright 2022, Elsevier.…”

Section: Oral Cancer and Oral Mucosal Diseasesmentioning

confidence: 99%

“…[ 275 ] For in situ tumor therapy, oral mucosal adhesive hydrogels can be applied as a patch or spray, as OSCC develops in the superficial sites of the oral cavity. [ 276 ] Furthermore, smart hydrogels can be developed to respond to different stimuli, such as pH, heat, light, and enzymes, enabling controlled release in the affected site of oral cancer. [ 277 ]…”

Section: Applications In Dental Medicinementioning

confidence: 99%

Hydrogels in Dental Medicine

Chen

Zhang

Peng

et al. 2023

Advanced Therapeutics

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Oral diseases are a prevalent global health problem that are primarily characterized by microbial infections, inflammation, and destruction of oral tissues. Maintaining good oral health is essential for a high quality of life, but the effective treatment of oral diseases and the regeneration of lost dental tissues remain challenging. Hydrogels have emerged as promising biomaterials in modern dental medicine. Their 3D network structures, high water content, good biocompatibility, and various bioactivities enable them to serve as drug delivery platforms, antimicrobial materials, tissue regeneration scaffolds, and biosensors. This review provides an overview of the formation mechanisms, structures, and functions of hydrogels, and highlights their latest applications in treating oral and maxillofacial diseases, such as periodontal diseases, caries, pulp diseases, oral cancer, and mucosal diseases.

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Loco-regional radiosensitizing nanoparticles-in-gel augments head and neck cancer chemoradiotherapy

Cited by 10 publications

References 46 publications

In Vitro Analysis of Superparamagnetic Iron Oxide Nanoparticles Coated with APTES as Possible Radiosensitizers for HNSCC Cells

In Vitro Analysis of Superparamagnetic Iron Oxide Nanoparticles Coated with APTES as Possible Radiosensitizers for HNSCC Cells

Hydrogels for the treatment of oral and maxillofacial diseases: current research, challenges, and future directions

Hydrogels in Dental Medicine

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