Hydrogels in Dental Medicine

Chen, Wener; Zhang, Chengfei; Peng, Siwu; Lin, Yifan; Ye, Zhou

doi:10.1002/adtp.202300128

Cited by 7 publications

(4 citation statements)

References 302 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Leveraging the adhesive and transport properties of hydrogels, medications can gradually diffuse into the periodontal pocket, ensuring prolonged and localized therapeutic effects without undesirable side effects. Hydrogel has demonstrated its suitability as a scaffold material for periodontal regenerative medicines [ 15 ]. The oral cavity is continuously exposed to diverse sources of oxidative stress, ranging from microbial infection and inflammation to dietary factors.…”

Section: Discussionmentioning

confidence: 99%

Development of the Antioxidant Property of Seagrass Extract-Based Hydrogel for Dental Application

Sarvesh,

Afeeza,

Suresh

et al. 2024

Cureus

View full text Add to dashboard Cite

Background Seagrass is rich in antioxidants, which can help neutralize harmful free radicals in the oral cavity. Free radicals can contribute to oxidative stress, inflammation, and various oral health issues. Incorporating seagrass extract into a hydrogel can enhance its antioxidant capacity, providing a protective effect for oral tissues. The hydrogel, composed of a biocompatible base, ensures that the material is well-tolerated by oral tissue. This is crucial for any dental application to avoid adverse reactions. Aim This work aimed to develop an antioxidant hydrogel that incorporates seagrass extract, with a specific emphasis on its possible use in dentistry. Methods A seagrass sample was collected, and its bioactive compounds were extracted through the utilization of methanol, and subsequent filtration was done. The resulting seagrass filtrate was then integrated into a hydrogel, which was synthesized using polyacrylamide and sodium alginate. Antioxidant hydrogel underwent testing for antioxidant activity through both the 2,2-diphenyl-1-picrylhydrazyl assay and the 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) assay. Besides, the hydrogel functional groups were investigated using Fourier transform infrared spectroscopy, while its crystalline structure was examined using X-ray diffraction analysis. Conclusion Seagrass extract provides inherent antioxidant properties, and incorporating this bioactive extract into the hydrogel imparts antioxidant features. The hydrogel's controlled-release property ensures both safety and efficiency. Antioxidant hydrogel for dental applications holds the potential to improve oral health.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of the Antioxidant Property of Seagrass Extract-Based Hydrogel for Dental Application

Sarvesh,

Afeeza,

Suresh

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Upon introduction into an fluid arrangement, these particles suddenly collect into supramolecular nanostructures. Outstandingly, self-assembled hydrogels show uncommon biocompatibility, focusing on specificity, and biomedical security, rendering them appropriate for the advancement of responsive materials [38].…”

Section: Bioink Developmentmentioning

confidence: 99%

Unlocking the Future: Bioprinting Salivary Glands—From Possibility to Reality

Shopova,

Yaneva,

Mihaylova

et al. 2024

JFB

View full text Add to dashboard Cite

Salivary gland biofabrication represents a promising avenue in regenerative medicine, aiming to address the challenges of salivary gland dysfunction caused by various factors such as autoimmune diseases and radiotherapy. This review examines the current state of bioprinting technology, biomaterials, and tissue engineering strategies in the context of creating functional, implantable salivary gland constructs. Key considerations include achieving vascularization for proper nutrient supply, maintaining cell viability and functionality during printing, and promoting tissue maturation and integration with surrounding tissues. Despite the existing challenges, recent advancements offer significant potential for the development of personalized therapeutic options to treat salivary gland disorders. Continued research and innovation in this field hold the potential to revolutionize the management of salivary gland conditions, improving patient outcomes and quality of life. This systematic review covers publications from 2018 to April 2024 and was conducted on four databases: Google Scholar, PubMed, EBSCOhost, and Web of Science. The key features necessary for the successful creation, implantation and functioning of bioprinted salivary glands are addressed.

show abstract

“…Antimicrobial hydrogels represent a promising strategy for oral drug delivery to effectively combat diverse oral infections, including periodontitis, dental caries, and oral candidiasis [ 163 , 164 ]. These hydrogels can be formulated as gels or mucoadhesive patches, enabling them to adhere to the oral mucosa, thereby facilitating sustained drug release and localized action.…”

Section: Translational Applicationsmentioning

confidence: 99%

Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications

Ortega,

De Leon-Oliva,

Boaru

et al. 2023

Gels

View full text Add to dashboard Cite

The growing impact of infections and the rapid emergence of antibiotic resistance represent a public health concern worldwide. The exponential development in the field of biomaterials and its multiple applications can offer a solution to the problems that derive from these situations. In this sense, antimicrobial hydrogels represent a promising opportunity with multiple translational expectations in the medical management of infectious diseases due to their unique physicochemical and biological properties as well as for drug delivery in specific areas. Hydrogels are three-dimensional cross-linked networks of hydrophilic polymers that can absorb and retain large amounts of water or biological fluids. Moreover, antimicrobial hydrogels (AMH) present good biocompatibility, low toxicity, availability, viscoelasticity, biodegradability, and antimicrobial properties. In the present review, we collect and discuss the most promising strategies in the development of AMH, which are divided into hydrogels with inherent antimicrobial activity and antimicrobial agent-loaded hydrogels based on their composition. Then, we present an overview of the main translational applications: wound healing, tissue engineering and regeneration, drug delivery systems, contact lenses, 3D printing, biosensing, and water purification.

show abstract

Hydrogels in Dental Medicine

Cited by 7 publications

References 302 publications

Development of the Antioxidant Property of Seagrass Extract-Based Hydrogel for Dental Application

Development of the Antioxidant Property of Seagrass Extract-Based Hydrogel for Dental Application

Unlocking the Future: Bioprinting Salivary Glands—From Possibility to Reality

Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications

Contact Info

Product

Resources

About