Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications

Ortega, Miguel A.; De Leon-Oliva, Diego; Boaru, Diego Liviu; Fraile-Martinez, Oscar; García-Montero, Cielo; Diaz, Raul; Coca, Santiago; Barrena-Blázquez, Silvestra; Bujan, Julia; García-Honduvilla, Natalio; Saez, Miguel A.; Álvarez-Mon, Melchor; Saz, Jose V.

doi:10.3390/gels9080617

Cited by 4 publications

(3 citation statements)

References 202 publications

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“…In this respect, the design/development of novel injectable multifunctional hydrogels encapsulating various types of bioactive agents and exhibiting self-healing, antibacterial activity and multi-stimuli responsiveness, via advanced technologies like electrospinning and 3D (bio)printing has recently become a hot research topic [5,17]. It should be noted that antimicrobial hydrogels (AMHs) are divided into hydrogels encapsulating antimicrobial agents and those with inherent antimicrobial properties [71]. Strategies for manipulating the regeneration of diabetic wounds include the use of hydrogels (loaded with small molecules and stem cells, etc.…”

Section: Hydrogel Dressingsmentioning

confidence: 99%

Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings

Kammona,

Tsanaktsidou,

Kiparissides

2024

Gels

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Wound healing is a physiological process occurring after the onset of a skin lesion aiming to reconstruct the dermal barrier between the external environment and the body. Depending on the nature and duration of the healing process, wounds are classified as acute (e.g., trauma, surgical wounds) and chronic (e.g., diabetic ulcers) wounds. The latter take several months to heal or do not heal (non-healing chronic wounds), are usually prone to microbial infection and represent an important source of morbidity since they affect millions of people worldwide. Typical wound treatments comprise surgical (e.g., debridement, skin grafts/flaps) and non-surgical (e.g., topical formulations, wound dressings) methods. Modern experimental approaches include among others three dimensional (3D)-(bio)printed wound dressings. The present paper reviews recently developed 3D (bio)printed hydrogels for wound healing applications, especially focusing on the results of their in vitro and in vivo assessment. The advanced hydrogel constructs were printed using different types of bioinks (e.g., natural and/or synthetic polymers and their mixtures with biological materials) and printing methods (e.g., extrusion, digital light processing, coaxial microfluidic bioprinting, etc.) and incorporated various bioactive agents (e.g., growth factors, antibiotics, antibacterial agents, nanoparticles, etc.) and/or cells (e.g., dermal fibroblasts, keratinocytes, mesenchymal stem cells, endothelial cells, etc.).

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Section: Hydrogel Dressingsmentioning

confidence: 99%

Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings

Kammona,

Tsanaktsidou,

Kiparissides

2024

Gels

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“…Hydrogels are three-dimensional (3D) networks that are created by crosslinked polymers and can swell in aqueous solutions. These hydrogels possess unique properties such as biocompatibility, low toxicity, wide availability, viscoelasticity, and biodegradability, making them suitable for numerous biomedical applications [61][62][63][64]. These include TERM (reviewed in this paper), wound dressing, contact lenses, 3D cell cultures, drug delivery, antimicrobial resistance treatment, and biosensing.…”

Section: Hydrogels: Concept Synthesis and Biomedical Applicationsmentioning

confidence: 99%

Advanced Hydrogel-Based Strategies for Enhanced Bone and Cartilage Regeneration: A Comprehensive Review

De Leon-Oliva,

Boaru,

Perez-Exposito

et al. 2023

Gels

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Bone and cartilage tissue play multiple roles in the organism, including kinematic support, protection of organs, and hematopoiesis. Bone and, above all, cartilaginous tissues present an inherently limited capacity for self-regeneration. The increasing prevalence of disorders affecting these crucial tissues, such as bone fractures, bone metastases, osteoporosis, or osteoarthritis, underscores the urgent imperative to investigate therapeutic strategies capable of effectively addressing the challenges associated with their degeneration and damage. In this context, the emerging field of tissue engineering and regenerative medicine (TERM) has made important contributions through the development of advanced hydrogels. These crosslinked three-dimensional networks can retain substantial amounts of water, thus mimicking the natural extracellular matrix (ECM). Hydrogels exhibit exceptional biocompatibility, customizable mechanical properties, and the ability to encapsulate bioactive molecules and cells. In addition, they can be meticulously tailored to the specific needs of each patient, providing a promising alternative to conventional surgical procedures and reducing the risk of subsequent adverse reactions. However, some issues need to be addressed, such as lack of mechanical strength, inconsistent properties, and low-cell viability. This review describes the structure and regeneration of bone and cartilage tissue. Then, we present an overview of hydrogels, including their classification, synthesis, and biomedical applications. Following this, we review the most relevant and recent advanced hydrogels in TERM for bone and cartilage tissue regeneration.

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“…Moreover, combining complementary therapeutic approaches with these antimicrobial hydrogels will improve their effectiveness. These hydrogels can have inherent antimicrobial activities or can be loaded with antimicrobial agents [104,105].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

New Insights in Hydrogels for Periodontal Regeneration

Santos,

dos Santos,

Carvalho

2023

JFB

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Periodontitis is a destructive inflammatory disease characterized by microbial infection that damages the tissues supporting the tooth (alveolar bone, gingiva, periodontal ligament, and cementum), ultimately resulting in the loss of teeth. The ultimate goal of periodontal therapy is to achieve the regeneration of all of the periodontal tissues. Thus, tissue engineering approaches have been evolving from simple membranes or grafts to more complex constructs. Hydrogels are highly hydrophilic polymeric networks with the ability to simulate the natural microenvironment of cells. In particular, hydrogels offer several advantages when compared to other forms of scaffolds, such as tissue mimicry and sustained drug delivery. Moreover, hydrogels can maintain a moist environment similar to the oral cavity. Hydrogels allow for precise placement and retention of regenerative materials at the defect site, minimizing the potential for off-target effects and ensuring that the treatment is focused on the specific defect site. As a mechanism of action, the sustained release of drugs presented by hydrogels allows for control of the disease by reducing the inflammation and attracting host cells to the defect site. Several therapeutic agents, such as antibiotics, anti-inflammatory and osteogenic drugs, have been loaded into hydrogels, presenting effective benefits in periodontal health and allowing for sustained drug release. This review discusses the causes and consequences of periodontal disease, as well as the advantages and limitations of current treatments applied in clinics. The main components of hydrogels for periodontal regeneration are discussed focusing on their different characteristics, outcomes, and strategies for drug delivery. Novel methods for the fabrication of hydrogels are highlighted, and clinical studies regarding the periodontal applications of hydrogels are reviewed. Finally, limitations in current research are discussed, and potential future directions are proposed.

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Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications

Cited by 4 publications

References 202 publications

Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings

Recent Developments in 3D-(Bio)printed Hydrogels as Wound Dressings

Advanced Hydrogel-Based Strategies for Enhanced Bone and Cartilage Regeneration: A Comprehensive Review

New Insights in Hydrogels for Periodontal Regeneration

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