Hydrogels for the treatment of oral and maxillofacial diseases: current research, challenges, and future directions

Huang, Mingshu; Huang, Yi‐Sheng; LIU, Hongyu; Tang, Zhengming; Chen, Yuanxin; Huang, Zhijie; Xu, Shuaimei; Du, Jianzhong; Jia, Bo

doi:10.1039/d2bm01036d

Cited by 22 publications

(18 citation statements)

References 301 publications

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“…[ 19 ] Fourth, the responsiveness to chemical, physical, and biological stimuli could be introduced into hydrogels for on‐demand delivery and sustained release of bioactive agents to improve therapeutic effects. [ 22 ] Therefore, tremendous advances have been made in the field of hydrogel delivery systems for periodontal applications.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Yin

Yang

et al. 2023

Adv Funct Materials

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Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on disease pathophysiology is essential for enhancing their therapeutic effects in periodontitis treatment. As promising localized drug delivery systems and tissue engineering scaffolds, hydrogels have gained significant interest for controlled and sustained release of bioactive agents in periodontal applications. The rational design of bioactive hydrogels can facilitate bacterial control and modulate destructive host inflammation, thereby preventing the progression of periodontitis. In this review, the pathophysiological mechanisms underlying periodontitis as fundamental principles for the design of functional hydrogel systems are first introduced. In the following part, an overview is systematically provided of the types and functions of the bioactive hydrogel systems loaded with anti‐bacterial and anti‐inflammatory agents for periodontal delivery. Finally, the remaining challenges and future perspectives of hydrogel delivery systems for periodontal applications are proposed. It is believed that this review will inspire the rational design and development of innovative functional hydrogel biomaterials toward periodontal therapy.

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Section: Introductionmentioning

confidence: 99%

Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Yin

Yang

et al. 2023

Adv Funct Materials

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“…24−28 Hydrogels enable long-term leaching of the agents with fewer reapplication cycles. 29,30 However, some limitations still exist, including uncontrolled and rapid drug release, microbial resistance build-up, and a lack of complete periodontal tissue regeneration. 31 Ideal hydrogels for PD treatment are expected to not only inhibit bacterial activity to control the inflammatory response but also foster tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Injectable dental biomaterials have gained popularity for the nonsurgical treatment of PD because of their conformability and facile flowability into the periodontal pocket. − Specifically, hydrogels are excellent candidates because of their biocompatibility, adhesion, biodegradation, affordability, and simple chemistry. , Gelatin methacryloyl (GelMA) is a common biomedical hydrogel that has been incorporated with different antimicrobial agents, including zinc, quaternary ammonium, and antibiotics (e.g., ciprofloxacin) for PD treatment. − Hydrogels enable long-term leaching of the agents with fewer reapplication cycles. , However, some limitations still exist, including uncontrolled and rapid drug release, microbial resistance build-up, and a lack of complete periodontal tissue regeneration . Ideal hydrogels for PD treatment are expected to not only inhibit bacterial activity to control the inflammatory response but also foster tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

A Novel Injectable Piezoelectric Hydrogel for Periodontal Disease Treatment

Roldan,

Montoya,

Solanki

et al. 2023

ACS Appl. Mater. Interfaces

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Periodontal disease is a multifactorial, bacterially induced inflammatory condition characterized by the progressive destruction of periodontal tissues. The successful nonsurgical treatment of periodontitis requires multifunctional technologies offering antibacterial therapies and promotion of bone regeneration simultaneously. For the first time, in this study, an injectable piezoelectric hydrogel (PiezoGEL) was developed after combining gelatin methacryloyl (GelMA) with biocompatible piezoelectric fillers of barium titanate (BTO) that produce electrical charges when stimulated by biomechanical vibrations (e.g., mastication, movements). We harnessed the benefits of hydrogels (injectable, light curable, conforms to pocket spaces, biocompatible) with the bioactive effects of piezoelectric charges. A thorough biomaterial characterization confirmed piezoelectric fillers' successful integration with the hydrogel, photopolymerizability, injectability for clinical use, and electrical charge generation to enable bioactive effects (antibacterial and bone tissue regeneration). PiezoGEL showed significant reductions in pathogenic biofilm biomass (∼41%), metabolic activity (∼75%), and the number of viable cells (∼2−3 log) compared to hydrogels without BTO fillers in vitro. Molecular analysis related the antibacterial effects to be associated with reduced cell adhesion (downregulation of porP and f imA) and increased oxidative stress (upregulation of oxyR) genes. Moreover, PiezoGEL significantly enhanced bone marrow stem cell (BMSC) viability and osteogenic differentiation by upregulating RUNX2, COL1A1, and ALP. In vivo, PiezoGEL effectively reduced periodontal inflammation and increased bone tissue regeneration compared to control groups in a mice model. Findings from this study suggest PiezoGEL to be a promising and novel therapeutic candidate for the treatment of periodontal disease nonsurgically.

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“…, hydrophilic three-dimensional (3D) networks of natural or synthetic polymers with enormous water retention capability) have been considered favorable scaffolds both for endodontics and periodontics. 13 Hydrogels can mimic the native extracellular matrix (ECM) of soft tissues owing to their viscoelastic properties; which encapsulate cells and contain a huge amount of water providing an active transport of biological molecules/cellular wastes and a delivery of bioactive agents loaded into hydrogels. 14,15…”

Section: Introductionmentioning

confidence: 99%

“…(i) Viscoelasticity: Among the various biomaterials used for scaffolding in tissue engineering applications, hydrogels (i.e., hydrophilic three-dimensional (3D) networks of natural or synthetic polymers with enormous water retention capability) have been considered favorable scaffolds both for endodontics and periodontics. 13 Hydrogels can mimic the native extracellu-…”

Section: Introductionmentioning

confidence: 99%

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

Atila,

Kumaravel

2023

Biomater. Sci.

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Hydrogels for the treatment of oral and maxillofacial diseases: current research, challenges, and future directions

Abstract: Oral and maxillofacial diseases such as infection and trauma often involve various organs and tissues, resulting in structural defects, dysfunctions and/or adverse effects on facial appearance. Hydrogels have been applied...

Cited by 22 publications

References 301 publications

Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

A Novel Injectable Piezoelectric Hydrogel for Periodontal Disease Treatment

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

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