Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes

Wang, Bo; Lucy, Katie A.; Schuman, Joel S.; Ishikawa, Hiroshi; Bilonick, Richard A.; Sigal, Ian A.; Kagemann, Larry; Chen, Lu; Fujimoto, James G.; Wollstein, Gadi

doi:10.1038/s41598-017-10042-5

Cited by 17 publications

(13 citation statements)

References 19 publications

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“…2G). Changes in vessel position, both within the ONH 25,26 relationships between glaucomatous ONH changes and development of prelaminar schisis, retinal abnormalities like peripapillary retinoschisis and paravascular defects. 10 In addition to the mechanical consequences of glaucomatous ONH deformation and remodeling, there may well also be alterations of physiology contributing to failure of homeostasis within the tissue under stress.…”

Section: Discussionmentioning

confidence: 99%

Association of Optic Nerve Head Prelaminar Schisis With Glaucoma

Lowry

Mansberger

Gardiner

et al. 2021

American Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Association of Optic Nerve Head Prelaminar Schisis With Glaucoma

Lowry

Mansberger

Gardiner

et al. 2021

American Journal of Ophthalmology

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“…using ImageJ software (version 1.52; Wayne Rasband, National Institutes of Health, Bethesda, MD). NI of CRVT location was defined as the distance of the CRVT to the temporal disk border divided by the whole disk diameter on the NA 12,13 . Average values of the NI measurements from the two examiners (K.S.…”

Section: Measurement Of Nasalization Index Of Crvt Location Optic DImentioning

confidence: 99%

Nasalization of Central Retinal Vessel Trunk Predicts Rapid Progression of Central Visual Field in Open-Angle Glaucoma

Shon

Shin

et al. 2020

Sci Rep

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Central visual field (CVF) loss is important in maintaining vision-related quality of life in eyes with open-angle glaucoma (OAG). The present study investigated whether nasalized location of central retinal vessel trunk (CRVT) at baseline is associated with rapid rate of CVF loss in early-stage OAG eyes. This study included 76 OAG eyes with high nasalization CRVT [HNL] group and 75 OAG eyes with low nasalization CRVT [LNL] group matched for glaucoma severity at baseline that showed progressive visual field (VF) loss. The rates of mean threshold changes at various regions were compared in the two groups using a linear mixed model. Clinical variables associated with rapid rate of CVF progression were also identified using a linear mixed model. The rate of CVF loss in the central 10° was significantly higher in the HNL group than that in the LNL group (−0.452 dB/year vs. −0.291 dB/year, P < 0.001). The average and inferior hemi-macular ganglion cell inner plexiform layer (GCIPL) progression rates were significantly faster in the HNL group than in the LNL group (P < 0.05). Nasalized location of CRVT was an independent predictor of a more rapid VF loss in the central 10° region (P < 0.05). The central visual field (CVF), which includes the 12 central-most points on standard 24-2 visual field (VF) testing, is strongly associated with activities of daily living, including "reading and seeing detail" 1,2. Hence, there would be clinical benefit in predicting CVF loss in the early stages of glaucoma, especially in eyes with progressive VF loss 2,3. Studies indicate that CVF loss may be associated with systemic and localized vascular insufficiency of the optic nerve head (ONH) in glaucoma patients 4-7. Central scotoma in patients with early-stage glaucoma is often associated with nocturnal hypotension, migraine, Raynaud's phenomenon, and sleep apnea 4,5. In addition, localized microvasculature dropout in the choroid surrounding the ONH has been linked to CVF defects in open-angle glaucoma (OAG) eyes 6,7. Nonetheless, it is of clinical relevance to identify other ocular/systemic conditions that are associated with CVF loss in glaucoma. The location of the central retinal vessel trunk (CRVT), which marks the exit position of the retinal vessels on the ONH, has been known to be associated with relative protection of nearest part of the neuroretinal rim tissue; the further away the region from the CRVT, the more likely it is affected by neuroretinal rim loss in glaucoma 8. In addition, the location of the central retinal vessel trunk (CRVT), has a close association with the lamina cribrosa (LC) beam thickness and surface depth in glaucoma 9,10. Moreover, the CRVT is located more nasally in glaucoma suspect and glaucomatous eyes compared with that in healthy eyes 11,12. Furthermore, nasalization of the CRVT was frequently found in OAG eyes with CVF loss at initial presentation regardless of glaucoma severity 13,14. These findings suggest that CRVT nasalization may be a potential structural clue for CVF loss in glaucoma. Therefo...

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“…To minimize such effect, we included only glaucoma patients of the early-to-moderate stage. It should be noted in this regard that glaucomatous ONH change has been reported to not affect the CRVT position in the LC portion 19,36 ;…”

Section: Discussionmentioning

confidence: 87%

Offset of Openings in Optic Nerve Head Canal at Level of Bruch’s Membrane, Anterior Sclera, and Lamina Cribrosa

Lee

Ahn

Kim

et al. 2021

Preprint

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We compared the central retinal vascular trunk (CRVT) position, as a surrogate of lamina cribrosa (LC) offset, with the anterior scleral opening (ASCO) offset from the Bruch’s membrane opening (BMO). Based on the BMO-centered radial scans, the BMO and ASCO margins were demarcated, and each center was determined as the center of the best-fitted ellipse for each margin. The ASCO/BMO offset was defined as the offset between each center. Angular deviations and the extent of ASCO and CRVT offsets from the BMO center were compared directly. Incomplete demarcation of ASCO was found in 20%, which was associated with a larger BMO area and a larger ASCO offset from the BMO. The angular deviation of ASCO offset was associated with that of CRVT offset and that of the longest externally oblique border. The ASCO offset was smaller than the CRVT offset, and, unlike the CRVT offset, it was rarely deviated to the inferior side. The complete ASCO margin might not be demarcateable when determined on BMO-centered radial scans in the presence of an offset. Also, the ASCO, which reflects only the superficial scleral layer, might not reflect the LC position, because the LC might be shifted further from the ASCO.

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Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes

Cited by 17 publications

References 19 publications

Association of Optic Nerve Head Prelaminar Schisis With Glaucoma

Association of Optic Nerve Head Prelaminar Schisis With Glaucoma

Nasalization of Central Retinal Vessel Trunk Predicts Rapid Progression of Central Visual Field in Open-Angle Glaucoma

Offset of Openings in Optic Nerve Head Canal at Level of Bruch’s Membrane, Anterior Sclera, and Lamina Cribrosa

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