The ACA tended to be narrowed at 18 months post-LPI despite resolution of pupillary block, which may be due to LV increment. Our results warrant continuous follow-up of narrow-angle patients after LPI.

PURPOSE.To investigate the possibility of classifying angle closure eyes in terms of features provided by anterior segment optical coherence tomography (AS OCT). METHODS. Angle closure (primary angle closure [PAC] or PAC glaucoma [PACG]) eyes diagnosed by gonioscopy were imaged using AS OCT under the same lighting conditions. Anterior chamber depth (ACD), anterior chamber width (ACW), iris cross-sectional area (IA), iris thickness at 750 lm from the scleral spur (IT750), iris curvature (IC), lens vault (LV), and anterior chamber area (ACA) were determined using Image J software (ver. 1.44). A hierarchical cluster analysis using Ward's method was performed using AS parameters obtained by AS OCT and axial length (AXL). RESULTS. A hierarchical cluster analysis was performed on 166 angle closure eyes and produced two clusters. The first cluster (84 eyes) was characterized by higher ACD (2.24 mm), higher ACA (12.5 mm 2 ), higher IT750 (0.44 mm), higher ACW (11.2 mm), lower LV (0.85 mm), and higher AXL (23.5 mm) compared with the second cluster (82 eyes, 1.82 mm, 9.5 mm 2 , 0.38 mm, 10.8 mm, 1.1 mm, and 22.8 mm, respectively). The second cluster had essentially higher LV and lower ACA than the first cluster. Most parameters were significantly different between two clusters except IC (P ¼ 0.76). CONCLUSIONS. Our hierarchical cluster analysis indicated two clusters with quite different features existed in our total angle closure population. Our results suggest the possibility of subclassifying angle closure eyes according to AS OCT parameters. (Invest Ophthalmol Vis Sci. 2013;54:848-853)

Purpose: To investigate the impact of systolic and diastolic blood pressure (DBP) dip at baseline on subsequent visual field (VF) progression in eyes with normal-tension glaucoma (NTG). Design: Prospective cohort study. Participants: This study included 119 eyes of 119 newly diagnosed NTG patients followed up for at least 2 years (average, 40.4AE16.9 months). Methods: All participants underwent baseline 24-hour ambulatory blood pressure (BP) monitoring and measurements of intraocular pressure (IOP) and at least 5 serial VF examinations. Participants were followed up as outpatients at 4-to 6-month intervals. Visual field progression was defined according to Early Manifest Glaucoma Trial criteria. The associations of VF progression with systolic BP (SBP) and DBP measured during the day and at night and other clinical variables were analyzed. Main Outcome Measures: Factors associated with VF progression over time. Results: During follow-up, 41 eyes (34%) showed VF progression. In the multivariate Cox regression model, lower nighttime trough DBP (hazard ratio, 0.953; P ¼ 0.023) and greater nighttime DBP dip area (time multiplied by nighttime DBP > 10 mmHg less than mean daytime DBP; hazard ratio, 1.017; P ¼ 0.003) at baseline were significant predictors of subsequent VF progression. None of the SBP parameters was associated with VF progression. Nocturnal DBP dip showed a greater association with VF progression than SBP dip. Conclusions: Nocturnal trough DBP and DBP dip area at baseline are significant predictors of subsequent VF progression in NTG. Nocturnal DBP dip may be more relevant to future VF progression than SBP dip in NTG eyes.