Locally elevated leukemia inhibitory factor in the inflamed fallopian tube resembles that found in tubal pregnancy

Ji, Yin; Chen, Li You; Xu, Kai; Yao, Ji Fen; Shi, Yuan

doi:10.1016/j.fertnstert.2008.01.110

Cited by 26 publications

(19 citation statements)

References 26 publications

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“…Increased immunohistochemical expression of LIF in fallopian tube was found to be increased in EP compared to non -pregnant and healthy pregnant controls, indicating its role in ectopic implantation of embryo [91]. Similarly it was observed that LIF expression was increased in inflamed fallopian tube and might be one of the reasons of increased susceptibility of salphingitis patients to EP [92].…”

Section: Leukemia Inhibitory Factor (Lif)mentioning

confidence: 71%

Biomarkers of Ectopic Pregnancy-Present and Future

Rajendiren¹,

Dhiman²

2015

Contemporary Gynecologic Practice

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Section: Leukemia Inhibitory Factor (Lif)mentioning

confidence: 71%

Biomarkers of Ectopic Pregnancy-Present and Future

Rajendiren¹,

Dhiman²

2015

Contemporary Gynecologic Practice

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“…However, the contribution of LIF expression to the pathogenesis of tubal pregnancy is still under debate (9-11). Ji and Keltz showed an increased expression of LIF in fallopian tubes from women with tubal pregnancy compared to nonpregnant women (9,10), while Kiran revealed that there was no significant difference in LIF expression between the tubal pregnancy group and early eutopic pregnancy group (11). Although the results are contradictory, their control groups were different from each other, which may have had an effect on their conclusions.…”

Section: Introductionmentioning

confidence: 93%

Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence

Li¹,

Lizhou²,

Zhao³

et al. 2015

Turk J Med Sci

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Background/aim: Tubal pregnancy is a major cause of maternal death in the first trimester and exploration of its underlying molecular mechanism is of great importance. This study aimed to explore the association of tubal pregnancy with leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) expression in oviduct tissues.Materials and methods: Immunohistochemistry was performed to probe the differential expression of LIF and LIFR in oviduct tissues among a control group (including NP group, n = 11; and IP group, n = 12), tubal pregnancy group (Ect-N group, n = 31; and Ect-A group, n = 40), and chronically inflamed group (including Inf-S group, n = 11; and Inf-P group, n = 9), followed by semiquantitative analysis.Results: Semiquantitative immunohistochemical analysis demonstrated that there was no significant difference in LIF expression in either the epithelial or stromal cells of oviduct tissues between the tubal pregnancy group and the control group (P < 0.05). However, LIF expression was remarkably elevated in the Inf-S and Inf-P group compared to the other groups (P < 0.05). In the epithelial cells of the fallopian tubes, LIFR expression was highest in the chronically inflamed group, followed by the tubal pregnancy group, outnumbering the control group (P < 0.05). More interestingly, an opposite expression trend of LIFR was observed in the stromal cells of the fallopian tubes among these groups (P < 0.05). Conclusion:Aberrant expression of LIF and LIFR might be associated with the occurrence of tubal pregnancy.

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“…Elevated PROKR2 expression in women with past C. trachomatis infection without acute infection suggests that TLR2 may also be responsible for longacting immuneresponses generated by C. trachomatis in FT's [58]. Since PROK's upregulate LIF and increased LIF expression in FT at implantation site compared to adjacent sites has been demonstrated in chronically inflammed tubes [59], they proposed that PROKR expression in response to C. trachomatis expression and cigarette smoke may lead to an increased PROK signaling resulting in upregulation of factors like LIF which signal to embryo regarding the suitably of environment for implantation [58].…”

Section: Prok's In Male Reproductive Functionmentioning

confidence: 99%

An update on the role of prokineticins in human reproduction-potential therapeutic implications

Kaur¹,

Allahbadia²,

Singh³

2013

OJGen

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Objective: Prokineticin-1 (PROK1) is a recently described protein with a wide range of functions including tissue specific angiogenesis, modulation of inflammatory responses and regulation of haematopoiesis. PROK1 has been found in the steroidogenic organs like ovary, testis, adrenal and specially placenta and they have been found to have a role in development of the olfactory system and GnRH system. The aim was to update the role of PROK1 and PROK2 in human reproduction since the review was provided by Maldono-Perez (2007) on the potentials of prokineticins in reproduction. Design: A review of international scientific literature by a search of Pubmed and the authors files was done for citation of articles relevant to prokineticins in reproduction, be it its role in ovary, testis, uterus with special emphasis on implantation, normal pregnancy, in labour, pathophysiological states like tubal pregnancy, pcos, various genital tumours, and cases of isolated hypogonadotropic hypogonadism with mutations with PROK2/ PROKR2 and studies detailing functional mechanisms. Results: In the normal cycle, PROK1 has been found to have important roles in implantation, regulating several genes like COX-2, IL-8, IL-11, CTGF related to implantation. Initially murine studies revealed a critical role of PROK2 pathway on olfactory bulb morphogenesis and GnRH secretion which was accidentally discovered and since then several studies on mutations in PROK2/PROKR2 showed that they underlie some case of KS in humans. Although in mouse heterozygote state is not associated with clinical phenotype, most of human mutations are heterozygous. Conclusions: Role of PROK-1 in the process of implantation, with a deeper understanding of the process success rates in IVF and ART can be improved, besides understanding the pathophysiology of tubal pregnancy. Further presence in ovarian follicles of PROK1 can be used to plan a strategy for treating pcos. Development of antagonism of PROK'S may be a helpful strategy in treating preterm labour.

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Locally elevated leukemia inhibitory factor in the inflamed fallopian tube resembles that found in tubal pregnancy

Cited by 26 publications

References 26 publications

Biomarkers of Ectopic Pregnancy-Present and Future

Biomarkers of Ectopic Pregnancy-Present and Future

Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence

An update on the role of prokineticins in human reproduction-potential therapeutic implications

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