Localized in vivo 1H nuclear MR spectroscopy for evaluation of human uterine cervical carcinoma.

Lee, Jun Young; Cho, Kyoung Sik; Kim, Y.-M.; Kim, S.-T.; Mun, Chi-Woong; Na, J.-H.; Mok, Jung Eun; Lim, Tae Hwan

doi:10.2214/ajr.170.5.9574601

Cited by 38 publications

(42 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…resonances in a clinical context, in vivo studies in cervical cancer 14,15 have been limited by technical factors such as the need to use an internal coil and obtain adequate water suppression. Our sample size was too small to consider stratification of spectra by tumour type and grade.…”

Section: Discussionmentioning

confidence: 99%

¹H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration

et al. 2004

View full text Add to dashboard Cite

The objective of this study was to establish in vivo (1)H-magnetic resonance (MR) spectroscopic appearances of cervical cancer using an endovaginal receiver coil and corroborate findings with magic angle spinning (MAS) MR spectroscopy of tissue samples. Fifty-three women (14 controls and 39 with cervical cancer) underwent endovaginal coil MR imaging at 1.5 T with T(1)- and T(2)-weighted scans sagittal and transverse to the cervix. Localized (1)H MR spectra (PRESS technique, TR 1600 ms, TE 135 ms) were accumulated in all controls and 29 cancer patients whose tumour filled > 50% of a single 3.4 cm(3) voxel. Peaks from triglyceride-CH(2) and -CH(3) were defined as present and in-phase (with the choline resonance), present but out-of-phase, or not present. Peak areas of choline-containing compounds were standardized to the area of unsuppressed tissue water resonance. Comparisons in observed resonances between groups were made using Fisher's exact test (qualitative data) and a t-test (quantitative data). Biopsies from these women analysed using MAS-MR spectroscopy and normalized to the intensity of an external standard of silicone rubber were similarly compared. Adequate water suppression permitted spectral analysis in 11 controls and 27 cancer patients. In-phase triglyceride-CH(2) resonances (1.3 ppm) were observed in 74% of tumours but in no control women (p < 0.001). No differences were observed in the presence of a 2 ppm resonance, choline-containing compounds or creatine in cancer compared with control women. However, ex vivo analysis showed significant differences not only in -CH(2), but also in -CH(3), a 2 ppm resonance, choline-containing compounds and creatine between tissues from control women and cancer tissue (p < 0.001, = 0.001, = 0.036, < 0.001 and = 0.004 respectively). On in vivo (1)H-MR spectroscopy, the presence of positive triglyceride-CH(2) resonances can be used to detect and confirm the presence of cervical cancer. However, technical improvements are required before routine clinical use.

show abstract

Section: Discussionmentioning

confidence: 99%

¹H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration

et al. 2004

View full text Add to dashboard Cite

show abstract

“…There are many reports of proton MRS of brain tumors, and CNS diseases [3,11]. Recently, the usefulness of proton MRS in the uterine cervix cancer [12,13], endometrial carcinoma [4], benign and malign ovarian tumors [4,14] and preeclamptic brain lesions [15] have also been recognized.…”

Section: Discussionmentioning

confidence: 99%

“…Some pathologic conditions yield detectable lipid signals at 0.9 and 1.3 ppm [3,11]. In tumors of the brain and uterine cervix an elevated lipid peak, is thought to be a possible indicator of malignancy [11,12]. Gotsis et al [21] reported that MRS demonstrated the presence of lipids in malignant brain tumors, abscesses and epidermoid cysts, but not in benign brain tumors.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Spectroscopy Features of Uterine Leiomyomas

Çelik

Saraç

Hasçalık

et al. 2004

Gynecol Obstet Invest

View full text Add to dashboard Cite

Objective: The purpose of this study is to investigate the in vivo magnetic resonance spectroscopy features of uterine leiomyomas using long echo time and to characterize the spectral patterns of these lesions. Methods: We calculated metabolites in 15 patients with uterine leiomyomas and myometrium of 20 healthy control subjects using single-voxel proton MR spectroscopy (point resolved spectroscopy technique, TE:136 ms). Voxels were placed at the center of the uterine leiomyomas. The peak areas of creatine, choline, lipid and lactate were determined. The MR spectroscopy results of uterine leiomyomas were compared with the spectroscopy results obtained from the myometrium of healthy control subjects. Results: The characteristically obtained signal was choline, which was detected not only in 14 of the 15 leiomyomas (93.3%) but also in 18 of the 20 myometrium of control subjects (90%). The lipid signals were determined in 9 of 15 patients with uterine leiomyomas (60%) and 8 of 20 control subjects (40%). The lactate signal was obtained from six of 15 patients with leiomyomas (40%) but only two of myometrium (10%). The creatine signal was obtained from 4 of 15 patients with leiomyomas (26.6%) and 5 of 20 myometrium (25%). Among the tested parameters only lactate peak was statistically significant (p < 0.05). Conclusion: Proton MR spectroscopic imaging may be helpful for the investigation of the underlying pathophysiology of uterine leiomyomas. The presence of lactate and lipid signals in the spectrum may be a useful indicator of metabolic pathway of uterine leiomyomas.

show abstract

“…This method also reveals concentrations of tissue metabolites that may refl ect the state of tissue function. MRS was recently used as a research tool in diagnosing endometrial disorders [2] , uterine leiomyomas [3] , uterine cervix cancer [4,5] and endometrial carcinoma [6] . N-acetylaspartate (NAA), choline (Cho) and creatine (Cr) are the major, whereas lipid and lactate are the minor metabolites of the relevant MRS spectra [1][2][3] .…”

mentioning

confidence: 99%

Synchronous Endometrial and Cervical Tumors in a 26-Year-Old Nullipara: Diagnostic Modalities Updated

Hasçalık

Çelik

Erdem

et al. 2005

Gynecol Obstet Invest

View full text Add to dashboard Cite

Proton magnetic resonance spectroscopy (MRS), performed on conventional magnetic resonance imaging (MRI) scanners, provides useful information at the biochemical level. MRS has been used to measure tissue concentrations of proton-containing compounds such as organic and amino acids, and sugars in living tissues. We have used MRS in a 26-year-old female with suspected cervical and endometrial carcinomas. With the use of the above mentioned technique, biochemical differences in the endometrium and the cervix tissues were detected. The presented case is the first virgin patient in the relevant literature in whom endometrial and cervical carcinoma was detected. Choline (Cho), creatine (Cr), N-acetylaspartate (NAA), lipid and lactate region of the MRS spectrum suggested that the technique could be used as an indicator of metabolic alterations in the cervical and endometrial tumor cells.

show abstract

Localized in vivo 1H nuclear MR spectroscopy for evaluation of human uterine cervical carcinoma.

Cited by 38 publications

References 0 publications

¹H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration

¹H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration

Magnetic Resonance Spectroscopy Features of Uterine Leiomyomas

Synchronous Endometrial and Cervical Tumors in a 26-Year-Old Nullipara: Diagnostic Modalities Updated

Contact Info

Product

Resources

About

Localized in vivo 1H nuclear MR spectroscopy for evaluation of human uterine cervical carcinoma.

Cited by 38 publications

References 0 publications

1H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration

1H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration

Magnetic Resonance Spectroscopy Features of Uterine Leiomyomas

Synchronous Endometrial and Cervical Tumors in a 26-Year-Old Nullipara: Diagnostic Modalities Updated

Contact Info

Product

Resources

About

¹H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration

¹H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration