Magnetic Resonance Spectroscopy Features of Uterine Leiomyomas

Çelik, Önder; Saraç, Kaya; Hasçalık, Şeyma; Alkan, Alpay; Mızrak, Bülent; Yoloğlu, Saim

doi:10.1159/000080020

Cited by 20 publications

(23 citation statements)

References 43 publications

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“…Celik et al 4 carried out one of the few studies of uterine MRS published in 2004, which compared metabolites seen with in vivo MR spectroscopy for 15 women with uterine leiomyomas and 20 healthy control subjects. Choline was detected in 14 of the 15 leiomyomas and also in 18 of the 20 controls.…”

Section: Discussionmentioning

confidence: 99%

In vivo magnetic resonance spectroscopy of gynaecological tumours at 3.0 Tesla

Booth

Pickles

Turnbull

2008

BJOG

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Background Magnetic resonance spectroscopy (MRS) uses the same hardware as MR imaging and allows us to analyse the biochemistry of tissues in vivo. Published data for gynaecological lesions are limited and are largely based on MRS carried out at the lower magnetic field strength of 1.5 Tesla (T).Objective The purpose of this study was to determine whether in vivo proton MRS could be performed at the higher magnetic field strength of 3 T to characterise the spectra of a variety of benign and malignant gynaecological lesions.Design Prospective, non-randomised study.Setting MRI department within a tertiary referral centre for gynaecological cancers.Sample All women with a pelvic mass under going 3T MRI.Methods We carried out MRS on nonrandomised women undergoing routine 3 T MRI within our MRI department during investigation for gynaecological lesions from February 2006 to April 2008. Only those women for whom histopathological data were available were included.Main outcome measures The presence of choline detected by in vivo 3T MRS.Results Eighty-seven women underwent MRS, 57 of whom had newly diagnosed neoplasms. MRS data for 39 of these new women (18 were excluded because of technical errors or missing data) were used to detect the presence of choline, an indicator of basement membrane turnover. Overall, choline was present in 13 of the 14 ovarian cancers, 8 of the 11 cervical tumours and all 4 of the uterine cancers. There was no statistical significant difference between choline levels in various lesion types (P = 0.735) or between benign and malignant disease (P = 0.550).Conclusions In vivo MRS can be performed at 3 T to provide biochemical information on pelvic lesions. The way in which this information can be utilised is less clear but may be incorporated into monitoring tissue response in cancer treatments.

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Section: Discussionmentioning

confidence: 99%

In vivo magnetic resonance spectroscopy of gynaecological tumours at 3.0 Tesla

Booth

Pickles

Turnbull

2008

BJOG

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“…Lactate, the end product of anaerobic glycolysis, appears at 1.3 ppm and is physiologically not detectable in the spectrum of a healthy human [1][2][3] . Lactate signal demonstrates a mismatch between glycolysis and oxygen supply [1][2][3] .…”

Section: Discussionmentioning

confidence: 99%

“…The semiquantifi ed evaluation of NAA, creatine, choline, lactate and lipid were conducted by a radiologist experienced in MRS. The classifi cation of metabolite peak areas in this study was performed according to the technique described by Celik et al [3] . In spectroscopy of the cervix, the region of interest for MRS measurement was placed at the center of the mass to avoid a contamination signal from the endometrium and myometrium.…”

Section: Case Reportmentioning

confidence: 99%

“…This method also reveals concentrations of tissue metabolites that may refl ect the state of tissue function. MRS was recently used as a research tool in diagnosing endometrial disorders [2] , uterine leiomyomas [3] , uterine cervix cancer [4,5] and endometrial carcinoma [6] . N-acetylaspartate (NAA), choline (Cho) and creatine (Cr) are the major, whereas lipid and lactate are the minor metabolites of the relevant MRS spectra [1][2][3] .…”

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Synchronous Endometrial and Cervical Tumors in a 26-Year-Old Nullipara: Diagnostic Modalities Updated

Hasçalık

Çelik

Erdem

et al. 2005

Gynecol Obstet Invest

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Proton magnetic resonance spectroscopy (MRS), performed on conventional magnetic resonance imaging (MRI) scanners, provides useful information at the biochemical level. MRS has been used to measure tissue concentrations of proton-containing compounds such as organic and amino acids, and sugars in living tissues. We have used MRS in a 26-year-old female with suspected cervical and endometrial carcinomas. With the use of the above mentioned technique, biochemical differences in the endometrium and the cervix tissues were detected. The presented case is the first virgin patient in the relevant literature in whom endometrial and cervical carcinoma was detected. Choline (Cho), creatine (Cr), N-acetylaspartate (NAA), lipid and lactate region of the MRS spectrum suggested that the technique could be used as an indicator of metabolic alterations in the cervical and endometrial tumor cells.

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“…Molecular imaging is a diagnostic method based on the observation of cells and molecular structures in vivo using different imaging modalities and new diagnostic and therapeutic markers [15]. MR spectroscopic imaging may be helpful for the investigation of the underlying pathophysiology of uterine leiomyomas [16] and wherever possible, MR Spectroscopy studies should provide detailed information about components of the metabolic peaks. The concentration ranges of metabolic components need to be defined in tumours, to determine if there are consistent patterns that differ from those in normal cells [17].…”

Section: Discussionmentioning

confidence: 99%

Peduncolated Mixoyd Leiomyoma: MR Imaging and Spectroscopy

Fiaschetti¹,

Fabiano²,

Coco³

et al. 2012

Gynecol Obstet

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Leiomyoma is the most common uterine tumor that occurs in more than 20% of women older than 30 years. This tumor presents different types of degenerations and a large variability in MRI imaging patterns. In literature ther is no case reported about leiomyomas spectroscopy. We report a case of 34 year-old woman who was admitted to the hospital for evaluation of an abdominal mass diagnosed at ultrasound. Physical examination revealed abdominal distension and abnormal uterine bleeding. Using abdominal MRI 3 Tesla we were able to determine the presence of a mass near uterine body very close to left ovarian. Laparotomy was performed and it showed a uterine peduncolated lesion. Histological examination proved smooth muscle cells and spindle-shaped cells separated by myxoid materials and ordinary myoma cells. This case report suggests that MR Spectroscopy may be able to allow distinction between benign and malignant lesions. It is important to differentiate leiomyomas from other diseases because of therapeutic treatment. In our case laparoscopic exeresis of the lesion permitted to preserve uterus and Patient's fertility.

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Magnetic Resonance Spectroscopy Features of Uterine Leiomyomas

Cited by 20 publications

References 43 publications

In vivo magnetic resonance spectroscopy of gynaecological tumours at 3.0 Tesla

In vivo magnetic resonance spectroscopy of gynaecological tumours at 3.0 Tesla

Synchronous Endometrial and Cervical Tumors in a 26-Year-Old Nullipara: Diagnostic Modalities Updated

Peduncolated Mixoyd Leiomyoma: MR Imaging and Spectroscopy

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