Localization of Retinoic Acid Receptors in Anterior Human Embryo

Sharma, Raghubir P.; Kim, Yang-Won

doi:10.1006/exmp.1995.1020

Cited by 4 publications

(2 citation statements)

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“…Retinoic acid (RA) is lipophilic molecule that act as ligand for nuclear RA receptors (RARs), converting them from transcriptional repressor to activators [2,11,12] in RA signaling pathway. It has been demonstrated that retinoic acid was identified as a morphogen(teratogen) responsible for the determination of the orientation of the limb outgrowth in chicken [13,14] and its retinoic acid receptors (RARs) appear at early stage of human embryonic development in certain types of tissues [15]. Vitamin A play a role in the differentiation of this cerebral nerve system in Xenopus laevi.…”

Section: Embryonic Developmentmentioning

confidence: 99%

Vitamin A and its Derivatives- Retinoic Acid and Retinoid Pharmacology

Zhu

2019

AJBSR

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Section: Embryonic Developmentmentioning

confidence: 99%

Vitamin A and its Derivatives- Retinoic Acid and Retinoid Pharmacology

Zhu

2019

AJBSR

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“…RARα and RARβ appear at early stages of human embryonic development, and their expression is restricted to certain types of tissues [3]. In the past decades, there were lots of studies reporting that alterations of RARs expressions were associated with the development of some diseases, such as squamous-cell carcinoma [4], mammary carcinomas [5], esophageal cancer [6], etc.…”

Section: Introductionmentioning

confidence: 99%

Association of Retinoic Acid Receptors with Extracellular Matrix Accumulation in Rats with Renal Interstitial Fibrosis Disease

Long

Qin

Zhou

et al. 2012

IJMS

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The nuclear retinoic acid receptors (RARs) function as ligand-dependent transcriptional regulators and include three subtypes (RARα, RARβ and RARγ), which control the expression of specific gene subsets subsequent to ligand binding and to strictly controlled phosphorylation processes. Extracellular matrix (ECM) accumulation is the most important characteristic of renal interstitial fibrosis (RIF). This study was performed to investigate whether RARs were associated with ECM accumulation in the progression of RIF in rats. Eighty Wistar male rats were divided into a sham operation group (SHO) and a model group subjected to unilateral ureteral obstruction (GU) at random; n = 40, respectively. The RIF disease in GU group was established by left ureteral ligation. The renal tissues were collected at two weeks and four weeks after surgery. Protein expressions of RARα, RARβ, RARγ, transforming growth factor-βl (TGF-β1), collagen-IV (Col-IV) and fibronectin (FN) were detected using immunohistochemical analysis, and mRNA expressions of RARα, RARβ, RARγ and TGF-β1 in renal tissue were detected by real time reverse transcription polymerase chain reaction. RIF index in renal interstitium was also calculated. When compared with those in SHO group, expressions of RARα and RARβ (protein and mRNA) were markedly reduced in the GU group (each p < 0.01). There was no marked difference for the expression of RARγ (protein and mRNA) between the SHO group and the GU group. The expressions of TGF-β1, Col-IV, FN and the RIF index in the GU group were markedly increased when compared with those in the SHO group (each p < 0.01). The protein expression of RARα/RARβ was negatively correlated with protein expression of TGF-β1, Col-IV or FN and the RIF index (all p < 0.01). In conclusion, the low expression of RARα/RARβ is associated with ECM accumulation in the progression of RIF in rats, suggesting that RARα/RARβ is a potentially therapeutic target for prevention of RIF.

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