Vitamin A and its Derivatives- Retinoic Acid and Retinoid Pharmacology

Zhu, George

doi:10.34297/ajbsr.2019.03.000656

Cited by 7 publications

(4 citation statements)

References 161 publications

(236 reference statements)

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“…They are crucial in the regulation of epithelial cell growth and cellular differentiation. Retinoid is necessary for vision and RA affects the pattern formation in developing and regenerating limbs and prevents the growth of some malignant cells (Zhu, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Clover microgreen incorporation in diet‐controlled diabetes and counteracted aflatoxicosis of rats

Aly,

Mohamed,

Khattab

et al. 2023

Food Science & Nutrition

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Diabetes mellitus is one of the chronic metabolic diseases whose control remains a challenge. Its increased incidence was mainly attributed to increased environmental contamination. Therefore, this study aims to investigate the effect of feeding clover microgreen (CM) on a diabetes model with or without aflatoxin exposure. Rats were distributed into 8 groups. G1 was a control group. G2 was fed CM. G3 was administered aflatoxin orally. G4 was fed clover and administered aflatoxin. G5 was diabetic rats. G6 was diabetic rats fed CM. G7 was diabetic rats administered aflatoxin. G8 was diabetic rats administered aflatoxin and fed CM. Phytochemical analysis of the CM showed that gardenin was the most common compound. The administration of aflatoxin aggravated diabetes. The groups fed CM showed a decreased glucose concentration compared to the unfed groups. Liver and kidney function parameters were improved by CM. The histopathological alteration of the pancreas, liver, and kidneys was relieved in CM‐fed groups. The area % of insulin in islets of Langerhans was increased in CM‐fed groups. Feeding CM also enhanced the oxidative stress biomarkers. In conclusion, CM improved all evaluated parameters in diabetic rats either exposed to aflatoxin or not compared to the control.

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Section: Discussionmentioning

confidence: 99%

Clover microgreen incorporation in diet‐controlled diabetes and counteracted aflatoxicosis of rats

Aly,

Mohamed,

Khattab

et al. 2023

Food Science & Nutrition

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show abstract

“…In the cell nucleus, RA regulates gene expression by binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs) ( Figure 3 a), which in turn activate the transcription of their downstream target genes ( Figure 3 a). The different isomers of RA activate different receptors, leading to different biological effects such as pro-apoptosis, anti-proliferation and differentiation of cells [ 75 , 78 , 79 ].…”

Section: Prospective Of Nanodiamonds In Bladder Cancer Managementmentioning

confidence: 99%

Nanodiamonds as Possible Tools for Improved Management of Bladder Cancer and Bacterial Cystitis

Zupančič

Veranič

2022

IJMS

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Nanodiamonds (NDs) are a class of carbon nanomaterials with sizes ranging from a few nm to micrometres. Due to their excellent physical, chemical and optical properties, they have recently attracted much attention in biomedicine. In addition, their exceptional biocompatibility and the possibility of precise surface functionalisation offer promising opportunities for biological applications such as cell labelling and imaging, as well as targeted drug delivery. However, using NDs for selective targeting of desired biomolecules within a complex biological system remains challenging. Urinary bladder cancer and bacterial cystitis are major diseases of the bladder with high incidence and poor treatment options. In this review, we present: (i) the synthesis, properties and functionalisation of NDs; (ii) recent advances in the study of various NDs used for better treatment of bladder cancer and (iii) bacterial cystitis; and (iv) the use of NDs in theranostics of these diseases.

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“…But the importance of vitamin A goes beyond visual health. Vitamin A is a regulator of cell growth and differentiation, embryogenesis, reproduction, epithelial cell integrity, and immune function [ 1 , 6 , 7 ]. In addition, it has antioxidant properties [ 8 ] and plays a role in protecting against oxidative stress damage and inflammation [ 1 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin A and Retinoids in Bladder Cancer Chemoprevention and Treatment: A Narrative Review of Current Evidence, Challenges and Future Prospects

Tratnjek

Jeruc

Romih

et al. 2021

IJMS

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Bladder cancer (BC) is the tenth most common cancer worldwide with a high recurrence rate, morbidity and mortality. Therefore, chemoprevention and improved treatment of BC are of paramount importance. Epidemiological studies suggest that adequate vitamin A intake may be associated with reduced BC risk. In addition, retinoids, natural and synthetic derivatives of vitamin A, are intensively studied in cancer research due to their antioxidant properties and their ability to regulate cell growth, differentiation, and apoptosis. Findings from in vivo and in vitro models of BC show great potential for the use of retinoids in the chemoprevention and treatment of BC. However, translation to the clinical practice is limited. In this narrative review we discuss: (i) vitamin A and retinoid metabolism and retinoic acid signalling, (ii) the pathobiology of BC and the need for chemoprevention, (iii) the epidemiological evidence for the role of dietary vitamin A in BC, (iv) mechanistic insights obtained from in vivo and in vitro models, (v) clinical trials of retinoids and the limitations of retinoid use, (vi) novel systems of retinoid delivery, and (vii) components of retinoid signalling pathways as potential novel therapeutic targets.

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Vitamin A and its Derivatives- Retinoic Acid and Retinoid Pharmacology

Abstract: This work is licensed under Creative Commons Attribution 4.0 License AJBSR.MS.ID.000656

Cited by 7 publications

References 161 publications

Clover microgreen incorporation in diet‐controlled diabetes and counteracted aflatoxicosis of rats

Clover microgreen incorporation in diet‐controlled diabetes and counteracted aflatoxicosis of rats

Nanodiamonds as Possible Tools for Improved Management of Bladder Cancer and Bacterial Cystitis

Vitamin A and Retinoids in Bladder Cancer Chemoprevention and Treatment: A Narrative Review of Current Evidence, Challenges and Future Prospects

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