Localization of biogenic amines in the foregut of <i>Aplysia californica</i>: Catecholaminergic and serotonergic innervation

Martinez-Rubio, Clarissa; Serrano, Geidy E.

doi:10.1002/cne.21991

Cited by 21 publications

(12 citation statements)

References 106 publications

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“…For example, the esophageal sensory nerve En, the reinforcement pathway that likely conveys food reward signals in vivo [36,42,52] and which mediates electrical stimulation-induced operant learning in vitro [38][39][40] is rich with DA-containing fibers [26,82] that provide synaptic input to buccal network elements, including the B51 [50] and B63 neurons [55]. Moreover, exogenous DA reproduces the effects of contingent reinforcement when applied to isolated B51 neurons in culture in a single cell analogue of operant conditioning [36,45].…”

Section: Ubiquity Of Dopamine In Mediating Associative Learningmentioning

confidence: 99%

Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in Aplysia

Nargeot

Simmers

2010

Cell. Mol. Life Sci.

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Associative learning in goal-directed behaviors, in contrast to reflexive behaviors, can alter processes of decision-making in the selection of appropriate action and its initiation, thereby enabling animals, including humans, to gain a predictive understanding of their external environment. In the mollusc Aplysia, recent studies on appetitive operant conditioning in which the animal learns about the positive consequences of its behavior have provided insights into this form of associative learning which, although ubiquitous, remains mechanistically poorly understood. The findings support increasing evidence that central circuit- and cell-wide sites other than chemical synaptic connections, including electrical coupling and membrane conductances controlling intrinsic neuronal excitability and underlying voltage-dependent plateauing or oscillatory mechanisms, may serve as the neural substrates for behavioral plasticity resulting from operant conditioning. Aplysia therefore continues to provide a model system for understanding learning and memory formation that enables establishing the neurobiological links between behavioral, network, and cellular levels of analysis.

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Section: Ubiquity Of Dopamine In Mediating Associative Learningmentioning

confidence: 99%

Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in Aplysia

Nargeot

Simmers

2010

Cell. Mol. Life Sci.

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“…Serotonin (5-hydroxytriptamine: 5-HT) is contained in the central nervous system (CNS) of gastropod molluscs, particularly in the buccal and cerebral ganglia, and is involved in the control of feeding behavior (Elekes, 1992;Gietzen et al, 1992;Kemenes, 1997;Hatakeyama and Ito, 1999;Proekt and Weiss, 2003;Jacklet et al, 2006;Martínez-Rubio et al, 2009). In the pond snail Lymnaea stagnalis, a pair of serotonergic giant interneurons called the cerebral giant cells (CGCs) are found in the cerebral ganglia, and are homologous to neurons sometimes called the metacerebral cells in other gastropod molluscs; the CGCs play key roles in the feeding system of the CNS (McCrohan and Benjamin, 1980b;Kyriakides and McCrohan, 1989;Kojima et al, 1997Kojima et al, , 2001Elliott and Vehovszky, 2000;Straub et al, 2007;Yeoman et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Multiple Subtypes of Serotonin Receptors in the Feeding Circuit of a Pond Snail

et al. 2011

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In the central nervous system of the pond snail Lymnaea stagnalis, serotonergic transmission plays an important role in controlling feeding behavior. Recent electrophysiological studies have claimed that only metabotropic serotonin (5-HT(2)) receptors, and not ionotropic (5-HT(3)) receptors, are used in synapses between serotonergic neurons (the cerebral giant cells, CGCs) and the follower buccal motoneurons (the B1 cells). However, these data are inconsistent with previous results. In the present study, we therefore reexamined the serotonin receptors to identify the receptor subtypes functioning in the synapses between the CGCs and the B1 cells by recording the compound excitatory postsynaptic potential (EPSP) of the B1 cells evoked by a train of stimulation to the CGC in the presence of antagonists: cinanserin for 5-HT(2) and/or MDL72222 for 5-HT(3). The compound EPSP amplitude was partially suppressed by the application of these antagonists. The rise time of the compound EPSP was longer in the presence of MDL72222 than in that of cinanserin. These results suggest that these two subtypes of serotonin receptors are involved in the CGC-B1 synapses, and that these receptors contribute to compound EPSP. That is, the fast component of compound EPSP is mediated by 5-HT(3)-like receptors, and the slow component is generated via 5-HT(2)-like receptors.

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“…the neurotransmitters, the cells use for communication. Catecholamines, one of the ‘classical’ neurotransmitters of the metazoans, have been extensively reported to be present in most animal groups (Sulston et al 1975; Hay-Schmidt 1990, 1992; Gonzalez and Smeets 1991; Pierre et al 1997; Pulver et al 2003; Faller et al 2008; Voronezhskaya et al 2008; Martínez-Rubio et al 2009), including members of Echinodermata. The occurrence of catecholaminergic cells and fibers has been demonstrated in the larvae of members from three of the representative groups of Echinodermata: Echinoidea, Asteroidea, and Holothuroidea.…”

Section: Introductionmentioning

confidence: 99%

The catecholaminergic nerve plexus of Holothuroidea

et al. 2010

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Catecholamines have been extensively reported to be present in most animal groups, including members of Echinodermata. In this study, we investigated the presence and distribution of catecholaminergic nerves in two members of the Holothuroidea, Holothuria glaberrima (Selenka, 1867) (Aspidochirotida, Holothuroidea) and Holothuria mexicana (Ludwig, 1875) (Aspidochirotida, Holothuroidea), by using induced fluorescence for catecholamines on tissue sections and immunohistochemistry with an antibody that recognizes tyrosine hydroxylase. The presence of a catecholaminergic nerve plexus similar in distribution and extension to those previously reported in other members of Echinodermata was observed. This plexus, composed of cells and fibers, is found in the ectoneural component of the echinoderm nervous system and is continuous with the circumoral nerve ring and the radial nerves, tentacular nerves, and esophageal plexus. In addition, fluorescent nerves in the tube feet are continuous with the catecholaminergic components of the radial nerve cords. This is the first comprehensive report on the presence and distribution of catecholamines in the nervous system of Holothuroidea. The continuity and distribution of the catecholaminergic plexus strengthen the notion that the catecholaminergic cells are interneurons, since these do not form part of the known sensory or motor circuits and the fluorescence is confined to organized nervous tissue.

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Localization of biogenic amines in the foregut of Aplysia californica: Catecholaminergic and serotonergic innervation

Cited by 21 publications

References 106 publications

Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in Aplysia

Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in Aplysia

Multiple Subtypes of Serotonin Receptors in the Feeding Circuit of a Pond Snail

The catecholaminergic nerve plexus of Holothuroidea

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