Local transversal aortic strain is impaired in ascending aorta dilatation

Cesareo, Marco; Sabia, Luca; Leone, Dario; Avenatti, Eleonora; Astarita, Anna; Mingrone, Giulia; Airale, Lorenzo; Veglio, Franco; Vallelonga, Fabrizio; Milan, Alberto

doi:10.1097/hjh.0000000000002757

Cited by 7 publications

(8 citation statements)

References 32 publications

(57 reference statements)

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“…In the present study, we detected lower concentrations of nornicotine in the urine of children with SHS compared to the other metabolites of nicotine, yet norcotinine was positively associated with AAO, suggesting a potential effect in affecting children’s cardiovascular structures. Dilation of the ascending aorta may be accompanied by blood vessel stiffness, which in turn may be associated with high blood pressure . A study found that a mother’s exposure to SHS during pregnancy was associated with an increase in the diameter of the aortic root of the child …”

Section: Discussionmentioning

confidence: 99%

Passive Smoking Exposure Modifies Cardiovascular Structure and Function: Beijing Child Growth and Health Cohort (PROC) Study

Xiao

et al. 2022

Environ. Sci. Technol.

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Passive smoking exposure in children is prevalent worldwide and exposes children to respiratory and systemic toxins. In this study, we enrolled 568 children to study how secondhand smoke (SHS) might affect children’s cardiovascular health in China. The measurement of nicotine and its metabolites in urine showed that 78.9% of children were exposed to SHS. Children exposed to SHS had greater interventricular septum thickness (p = 0.005) and left ventricular mass index (p = 0.008) than nonexposed children. Urinary norcotinine levels were associated with increased ascending aorta diameter (β = 0.10, 95%CI 0.02–0.17) and decreased left ventricular end systolic diameter (β = −0.10, 95%CI −0.19 to −0.01). The effects of SHS exposure on cardiovascular function: norcotinine levels associated with lower left ventricular mass index (β = −0.32, 95%CI −0.59 to −0.05), left ventricular end diastolic volume index (β = −0.43, 95%CI −0.85 to −0.02), and left ventricular end systolic volume index (β = −0.20, 95%CI −0.37 to −0.03). Moreover, there no no significant associations of nicotine, cotinine, and trans-3′-hydroxycotinine with cardiovascular health. Overall, SHS exposure in children remains prevalent in Beijing and may affect children’s cardiovascular development, in both structure and function. It suggests that stricter and practical measures are needed toward the elimination of tobacco use in children’s environments.

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Section: Discussionmentioning

confidence: 99%

Passive Smoking Exposure Modifies Cardiovascular Structure and Function: Beijing Child Growth and Health Cohort (PROC) Study

Xiao

et al. 2022

Environ. Sci. Technol.

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“…These findings may be more representative of the actual clinical scenario than the linear relationship. Previous research has linked ascending aortic dilatation to increased aortic stiffness and left ventricular hypertrophy ( 21 , 22 ). They are both independent risk factors for HF prognosis.…”

Section: Discussionmentioning

confidence: 99%

The non-linear association between ascending aorta diameter and risk of 12-month mortality in Chinese patients with heart failure: A retrospective cohort study

Chen

Huang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundThere is no conclusive proven link between ascending aorta diameter (AoD) and the risk of death from heart failure (HF). As a result, a retrospective cohort analysis was carried out to determine whether AoD is associated with 12-month mortality in Chinese HF patients.MethodsFrom January 2017 to March 2020, we collected data on 575 Chinese patients with HF. The exposure and outcome variables were baseline AoD and 12-month risk of mortality (all-cause + cardiac origin), respectively. Data on demographics, drug usage, clinical characteristics, recognized indicators of HF, and comorbidities were included as covariates. To investigate the independent relationships of AoD with the risk of 12-month death, binary logistic regression and two-piecewise linear models were utilized.ResultsOur findings imply that there was a non-linear relationship between AoD and the risk of 12-month mortality. For the AoD range of 23 to 37, there was no association with the risk of cardiac mortality [odds ratio (OR) 0.78, 95% confidence interval (CI), 0.62–1.04]. In the AoD range of 37–49, however, the risk of 12-month cardiac death increased by approximately 70% for every 1 mm increase in AoD (OR 1.70, 95% CI, 1.13–2.55). When all-cause death was chosen as the outcome, the same outcome was shown.ConclusionAn AoD larger than 37 mm is a hazardous threshold for Chinese HF patients. Beyond this limit increased the risk of cardiac death by 70% for every 1 mm increase in AoD.

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“…Therefore, as Murakami and Shiraishi insightfully observed, we assumed carotid-femoral pulse wave velocity (cfPWV) as a marker of aortic stiffness along the entire arterial tree, although cfPWV does not consider pulse wave velocity of the ascending aorta. Anyway, we would like to highlight that we evaluated ASC diameter and regional stiffness in another work from our group [6]. Cesareo and co-workers adopted speckle-tracking technology in order to derive beta stiffness index (bSi) of ASC, as a local marker of stiffness [7].…”

Section: Replymentioning

confidence: 99%