Local mononuclear cell infiltrates in infertile patients with endometrial macropolyps versus micropolyps

Kitaya, Kotaro; Tada, Yoshihiro; Taguchi, Sagiri; Funabiki, Miyako; Hayashi, Terumi; Nakamura, Yoshitaka

doi:10.1093/humrep/des323

Cited by 77 publications

(81 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the Japanese population, the incidence of obesity in infertile women with PCOS is significantly lower compared to that reported in Caucasian populations (5). The incidence of PCOS in our cohort was significantly higher in the patients who developed moderate-to-severe OHSS compared to that in non-OHSS patients, whereas there were no obese women in the two groups.…”

Section: Discussionmentioning

confidence: 66%

See 1 more Smart Citation

Low follicular fluid tyrosine concentration in infertile women with ovarian hyperstimulation syndrome

Amano¹,

Kitaya²,

Taguchi³

et al. 2014

Biomedical Reports

View full text Add to dashboard Cite

The aim of this study was to compare the branched-chain amino acid (BCAA) and tyrosine concentration in the follicular fluid of infertile women with and without ovarian hyperstimulation syndrome (OHSS) in an in vitro fertilization program combined with controlled ovarian stimulation. Follicular fluid was aspirated during oocyte retrieval from 20 infertile patients who developed moderate-to-severe OHSS and 20 age- and body mass index-matched normoresponders. BCAA and tyrosine concentration were measured using enzymatic methods. The follicular fluid BCAA concentration was similar between the two groups (P=0.55), whereas tyrosine concentration was significantly lower in the OHSS compared to that in the normoresponder group (P=0.027) and the BCAA/tyrosine ratio was significantly higher in the OHSS compared to that in the normoresponder group (P=0.034). These results suggest an association between low follicular fluid tyrosine concentration and OHSS. Dopamine receptor agonists may be used as potential anti-OHSS medicines and tyrosine, as a dopamine precursor, may play a role against the development of OHSS.

show abstract

Section: Discussionmentioning

confidence: 66%

“…All the patients had undergone controlled ovarian stimulation using gonadotropin-releasing hormone agonist (short protocol) or antagonist (flexible protocol) (5). The follicular fluid samples were immediately frozen at −80°C until measurement.…”

Section: Methodsmentioning

confidence: 99%

Low follicular fluid tyrosine concentration in infertile women with ovarian hyperstimulation syndrome

Amano¹,

Kitaya²,

Taguchi³

et al. 2014

Biomedical Reports

View full text Add to dashboard Cite

show abstract

“…Johnston-MacAnanny et al [78] showed that 70% of cases of CE demonstrated in EM biopsies were cured by a regimen of 100 mg of doxycycline twice per day for 14 days. Kitaya et al [79] also reported that the histological clearance rate of CD138+ plasma cells on the EM of RIF patients with CE was up to 96% using the above doxycycline-only regimen. The histopathologic cure rate of CE using a combination of ofloxacin (400 mg twice per day for 14 days) and metronidazole (500 mg twice per day for 14 days) was 73% [14].…”

Section: Treatment Of Cementioning

confidence: 99%

Chronic endometritis and infertility

Park

Kim

Yoon

et al. 2016

Clin Exp Reprod Med

129

109

View full text Add to dashboard Cite

Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease. However, the relationship between CE and infertility-related conditions such as repeated implantation failure and recurrent miscarriage has recently emerged as an area of inquiry. In this study, we reviewed the literature on the pathophysiology of CE and how it may be associated with infertility, as well as the literature regarding the diagnosis and treatment of CE. In addition, we discuss the value of hysteroscopic procedures in the diagnosis and treatment of CE.

show abstract

“…Valószínűleg a polip környezetében megváltozott lokális immunfunkciók a felelősek az ismételt vetélésekért [20]. Az in vitro fertilizáció programban részt vevő páciensek körében 6-8%-ban találnak endometriumpolypust hiszteroszkóp segítségével [21].…”

Section: Irodalomunclassified

A méhüreg anatómiai rendellenességei habituális vetélőkben

et al. 2015

View full text Add to dashboard Cite

Bevezetés: A habituális vetélés a nők 1%-át érintő rendellenesség, amelynek hátterében genetikai, endokrin, méhűri anatómiai, immunológiai, mikrobiológiai és hematológiai, valamint andrológiai zavarok mutathatók ki mint kocká-zati tényezők, de az esetek felében ismeretlen ok miatt alakul ki. Célkitűzés: A habituális vetélés kockázati tényezőinek kutatása során a szerzők arra a kérdésre kerestek választ, vajon a magyar lakosságban milyen gyakran fordul elő a méhüreget érintő anatómiai rendellenesség. Módszer: Retrospektív módon dolgozták fel 152 habituális vetélő adatait. Az esetleges méhűri eltérés tisztázására 132 betegben vagy diagnosztikus hiszteroszkópia, vagy a méhüreg 3 dimenziós ultrahangvizsgálata, 16 esetben hysterosalpingographia, 4 esetben hysterosalpingo-sonographia történt. Eredmények: Megállapították, hogy a habituális vetélők 15,8%-ában méhűri rendellenesség mutatható ki. A rendellenességek közül septum uteri 6,5%-ban, endometriumpolypus 2,6%-ban, uterus arcuatus 2%-ban, uterus bicornis 2%-ban, submucosus myomagöb 1,3%-ban és méhűri synechiák 1,3%-ban fordultak elő. Következtetések: A szerzők megfi gyelése arra utal, hogy habituális vetélésben szenvedő nőkben a méhüreg morfológiai rendellenessége gyakori. Ilyen esetekben javasolt a méhüreg anatómiai vizsgálata. Orv. Hetil., 2015, 156(27), 1081-1084. Kulcsszavak: habituális vetélés, méhűri rendellenesség Uterine anomalies in women with recurrent pregnancy lossIntroduction: One percent of couples trying to have children are affected by recurrent miscarriage. These pregnancy losses have different pathogenetic (genetic, endocrine, anatomic, immunologic, microbiologic, haematologic and andrologic) backgrounds, but recurrent miscarriage remains unexplained in more than half of the affected couples. Aim: To explore risk factors for recurrent pregnancy loss the authors studied the incidence of anatomic disorders of the uterine cavity occur in Hungarian women with recurrent miscarriage. Method: Medical records of 152 patients with recurrent miscarriage were analyzed retrospectively. In order to explore disorders of the uterine cavity hysteroscopy or 3-dimensional sonography in 132 women, hysterosalpingography in 16 and hysterosalpingo-sonography in 4 patients were used. Results: Incidence of anomalies in the uterine cavity was found in women with recurrent miscarriage to be 15.8%. A variety of the uterine anomalies was found including uterine septum in 6.5%, endometrial polyp in 2.6%, arcuate and bicornuate uteri both in 2% and 2%, submucosal myoma in 1.3 %, and intrauterine synechiae in 1.3%. Conclusions: These fi ndings suggest that morphologic disorder of the uterine cavity is frequent in Hungarian women with recurrent miscarriage. Therefore, assessment of the uterine anatomy is recommended in such patients.

show abstract

Local mononuclear cell infiltrates in infertile patients with endometrial macropolyps versus micropolyps

Abstract: This study was supported by Grand-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (22591840). There were no conflicts of interest to declare.

Cited by 77 publications

References 23 publications

Low follicular fluid tyrosine concentration in infertile women with ovarian hyperstimulation syndrome

Low follicular fluid tyrosine concentration in infertile women with ovarian hyperstimulation syndrome

Chronic endometritis and infertility

A méhüreg anatómiai rendellenességei habituális vetélőkben

Contact Info

Product

Resources

About