Local Glucocorticoids in Treatment of Children with Dermatitis

Левина, Ю. Г.; Намазова-Баранова, Л. С.; Эфендиева, К. Е.; Алексеева, А.А.; Вишнёва, Е. А.; Калугина, В. Г.; Аримова, П. С.

doi:10.15690/vsp.v18i5.2063

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…МЕТОДЫ ПРОФИЛАКТИКИ И ПРЕДОТВРАЩЕНИЯ РАЗВИТИЯ «АТОПИЧЕСКОГО МАРША» Учитывая вышеперечисленные сведения о патогенезе, важнейшей задачей в предотвращении развития «атопического марша» является осуществление эффективных и незамедлительных действий, направленных непо-/ 2020 / ТОМ 19 / № 4S CURRENT PEDIATRICS / 2020 / V. 19 / № 4S средственно на купирование воспаления и восстановление эпидермального барьера. Проактивное лечение, направленное на подавление острого воспалительного кожного процесса, включает топические глюкокортикостероиды (тГКС), которые могут быть безопасно использованы в течение 20 нед [38][39][40]. Одним из актуальных тГКС 3-го класса активности (сильные), по Европейской классификации Miller и Munro, продемонстрировавших наиболее благоприятное соотношение «риск-польза» и показавших высокий профиль безопасности, эффективности и переносимости в использовании у детей раннего возраста, является метилпреднизолона ацепонат (МПА) [41][42][43].…”

Section: эпидемиология «атопического марша»unclassified

Modern Outlooks on «Atopic March» Secondary Prevention Capabilities in Children with Atopic Dermatitis

Мурашкин

Намазова-Баранова

Иванов

et al. 2020

Vopr. sovr. pediatr.

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Atopic dermatitis (AD) is one of the most common inflammatory diseases of childhood, and it is the first one in gradual development of allergic diseases, also known as «atopic march». Sensitization establishment during the AD uncontrolled course is associated with the high risk of developing of serious allergic pathologies, increase in the severity of the disease course, and patients’ quality of life reduction. Thereby, it is crucial to achieve quick jugulation of the inflammatory process in case of severe AD with early onset of disease. This article shows modern therapeutic approaches to disease control in children.

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Section: эпидемиология «атопического марша»unclassified

Modern Outlooks on «Atopic March» Secondary Prevention Capabilities in Children with Atopic Dermatitis

Мурашкин

Намазова-Баранова

Иванов

et al. 2020

Vopr. sovr. pediatr.

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Atopic dermatitis management with topical corticosteroids in children: own observations

Skorokhodkina

Zaynetdinova²,

Хакимова

2023

Medicinskij sovet

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Atopic dermatitis is the most common chronic inflammatory skin disease in children, that significantly affects quality of life. Clinical manifestations are genetically determined and caused by skin barrier dysfunction and development of immune reactions. Atopic dermatitis is characterized by early onset, recurrence, and presence of treatment resistant forms. It is important to prescribe treatment that controls the symptoms and reduces the risk of severe forms of this disease. Topical corticosteroids are the mainstay of atopic dermatitis management, although the prolonged treatment can lead to development of side effects. The treatment option, that has high efficacy and high profile of safety, is the basis for disease remission and overcoming corticosteroid phobia. Methylprednisolone aceponate meets all criteria for topical corticosteroids and has high efficacy and high profile of safety. It can be recommended for patients with atopic dermatitis from the age of 4 months. This paper shows up-to-date data on methylprednisolone aceponate, that confirm the optimized efficacy/safety profile and minimal local or systemic adverse effects. Recent studies demonstrated the efficacy of new Russian product – methylprednisolone aceponate (Komfoderm K).

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Prospects for the use of adequate external therapy for atopic/allergic dermatitis in children

Zakirova,

Shayapova,

Vakhitov

et al. 2023

Medicinskij sovet

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The article focuses on the most frequent skin diseases in young children. Atopic/allergic dermatitis is one of the most common diseases in children. Approximately 45% of patients develop their first symptoms within the first 6 months after birth, 60% show the onset of atopic dermatitis during the first year of life and 80-85% at the age of 1 to 5 years. The article also speaks about the issue of allergic contact dermatitis (diaper rash in newborns). The disease represents non-specific inflammatory skin changes in the contact area in infants, the onset of which occurs mostly at the age of 1 to 15 months. The factors responsible for causing these diseases, the pathogenesis of their development and the potential of topical therapy mainly targeted at the reduction of clinical manifestations and frequency of exacerbations, improvement of the quality of life and prevention of infectious complications are considered. As an initial treatment, the authors consider a drug containing methylprednisolone aceponate with ceramides of domestic manufacturing. Its effectiveness and safety in the combination therapy of young children suffering from atopic/allergic and contact dermatitis may be evaluated in clinical practice. Clinical case reports of treatment of children with dermatitis of various etiologies aged from 4.5 months up to 3 years are presented. The outcomes of the use of Komfoderm K in children with AD demonstrated a significant decrease in the severity of inflammation, reduction of the skin lesion area and the intensity of symptoms, decreased need for additional intake of antihistamines and anti-inflammatory drugs, and the ability to achieve stable clinical remission.

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Local Glucocorticoids in Treatment of Children with Dermatitis

Cited by 3 publications

References 38 publications

Modern Outlooks on «Atopic March» Secondary Prevention Capabilities in Children with Atopic Dermatitis

Modern Outlooks on «Atopic March» Secondary Prevention Capabilities in Children with Atopic Dermatitis

Atopic dermatitis management with topical corticosteroids in children: own observations

Prospects for the use of adequate external therapy for atopic/allergic dermatitis in children

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