Local Chemotherapy in Bladder Cancer Treatment

Abstract

Intravesical chemotherapy can be employed either in a therapeutic aim or as an adjuvant prophylactic treatment after TUR. In this paper a discussion is presented about various controversial points that need to be clarified with regard to topical chemotherapy, with special reference to the selection of the drug and to various modalities of treatment. Some results are presented from the literature and from the author’s personal experience, with emphasis on the randomized clinical trials performed by EORTC and by other workers or groups.

Intravesical chemotherapy of superficial bladder tumors in a controlled trial with cis‐platinum versus Cis‐platinum plus hyaluronidase

“…Intravesical chemotherapy has been employed for almost 20 years [5], and different drugs have been and still are being evaluated to improve results. Investigations are going on with various drugs studying different dose schedules or interval regimens.…”

“…Although some discouraging results were pub-the nurses Amira Markovitz and Lina Spigel. lished in the literature with CDDP [5,17,18], we accept the statement by Blumenreich et a1 [17] that the failure of from Hadassah-Wizo, Canada.…”

Adjuvant Intravesical Chemotherapy of Superficial Bladder Cancer with Monthly Doxorubicin or Intensive Mitomycin A Comparison of Two Consecutive Series

“…either doxorubicin or mitomycin [12][13][14][15], Finally, evi dence to document a correlation between the intensity of treatment and its adjuvant efficacy is lacking [11,12]. The long-term objective of our study is to compare the adjuvant results and the feasibility of a relatively mild regimen of doxorubicin to those of a substantially more intensive treatment with mitomycin.…”

Intravesical Instillation with Adriamycin + Tween 80 in Patients with Superficial Bladder Tumors

“…Superficial and papillary bladder tumors have been treated with intravesical instillation of various chemo therapeutic drugs [1][2][3][4][5]. Among the drugs used for instil lation therapy adriamycin seems to give a superior thera peutic response [6][7][8][9][10][11].…”