Intravesical Instillation with Adriamycin + Tween 80 in Patients with
Superficial Bladder Tumors

Eksborg, Staffan; Edsmyr, F; Näslund, Ingemar

doi:10.1159/000473520

Cited by 12 publications

(4 citation statements)

References 6 publications

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“…However, only a few cases of therapyrelated severely contracted bladders, due to intravesical instillation therapy with antineoplastic drugs, have in fact been reported [8][9][10][11]. The mean values of the BCinjt/BC ratios were close to unity during instillation therapy with adriamycin in phosphate buffer with or without added Tween 80 [11,13], indicating that the BC did not signif icantly change as a result of the instillations.…”

Section: Discussionmentioning

confidence: 93%

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Intravesical Instillation of Adriamycin: Influence on Bladder Capacity

Eksborg¹,

Edsmyr²,

Andersson³

1985

Eur Urol

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Section: Discussionmentioning

confidence: 93%

“…1). It should be noted that, in some patients treated by a large number of instillations, essentially unaffected BCs have also been reported [13].…”

Section: Discussionmentioning

confidence: 99%

Intravesical Instillation of Adriamycin: Influence on Bladder Capacity

Eksborg¹,

Edsmyr²,

Andersson³

1985

Eur Urol

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“…In comparative studies between thiotepa and adria mycin [4,24,27], no significant differences were found between the percentage of recurrences corresponding to each drug, although the recurrence rate was less in the patients treated with adriamycin [2,17], The addition of urokinase was not shown to increase its action [25], nor did the inclusion of Tween 80 [13], The action of adria mycin on in situ carcinoma is interesting. Jakse et al [19][20][21] showed tumoral remission as long as 24 months after the use of adriamycin, and suggest that before decid ing on cystectomy, this drug should be used first.…”

Section: Discussionmentioning

confidence: 99%

Thiotepa versus Adriamycin versus Cis-Platinum in the Intravesical Prophylaxis of Superficial Bladder Tumors

Llopis¹,

Gallego²,

Mompó³

et al. 1985

Eur Urol

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A study was performed on 184 patients with superficial bladder cancer (pTa, pT1), 92 with primary and 92 recurrent tumors. After TUR of all visible lesions, endovesical chemotherapy with thiotepa, adriamycin or cisplatinum was started on the 15th and 30th days following surgery. There were no statistically significant differences between any of the three chemotherapies at the doses and intervals mentioned. Only cis-platinum has proven to be more effective in primary high grade tumor.

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“…Two delivery systems were chosen for these studies: one is a solution of Tween 80 in saline, and the other is an emulsion of Cre-mophor@ EL in propylene-glycol and saline. Tween 80 has been used as a vehicle both for nonphotosensitizer anticancer drugs (25,26) and for photosensitizers (2 1,23). CremophorB EL (BASF), the trademark for a polyethyleneglycol triricinoleate, has widespread use as a vehicle for cyclosporine, a hydrophobic antirejection drug.…”

Section: Introductionmentioning

confidence: 99%

Effect of Delivery System on the Pharmacokinetics and Tissue Distribution of bis(Di‐lsobutyl Octadecylsiloxy)Silicon 2,3‐Naphthalocyanine (isoBOSINC), a Photosensitizer for Tumor Therapy

Zuk

Rihter

Kenney

et al. 1996

Photochem & Photobiology

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Bis(di-isobutyl octadecylsiloxy)silicon 2,3-naphthalocyanine (isoBOSINC) is a representative of a group of naphthalocyanine derivatives with spectral and photophysical properties that make them attractive candidates for photodynamic therapy (PDT). Tissue distributions were studied in tumor-bearing rats as a function of delivery system and time following administration. The tumor model was an N-(4-[5-nitro-2-furyl]-2-thiazolyl) formamide (FANFT)-induced urothelial cell carcinoma transplanted into one hind leg of male Fischer 344 rats; isoBOSINC was delivered to the rats by intravenous injection of 0.50 mg/kg of body weight as a suspension either in 10% Tween 80 in saline (Tween) or 10% (Cremophor EL + propylene glycol) in saline (Cremophor). The isoBOSINC was isolated from several tissues and organs, as well as tumors and peritumoral muscles and skin. Quantitation was by a high-performance liquid chromatographic technique with detection that utilizes the native fluorescence of the naphthalocyanine derivative. Independent of the delivery system, the dye was retained in tumors at higher concentrations than in normal tissues, except for spleen and liver. The isoBOSINC retention in tumors was high and was vehicle dependent. For Tween, the maximal ratio of dye in tumor versus peritumoral muscle occurred 12 h after injection; for Cremophor, the maximal ratio occurred later, 336 h postinjection. When the drug was delivered in Tween, isoBOSINC in serum showed two compartment kinetics: half-lives of about 2 and 11 h were found for the distribution and the elimination phases, respectively. When Cremophor was the vehicle, the elimination half-life was about 20 h, and one compartment kinetics was observed. The latter findings may explain the generally higher levels of the dye attained by the tissues at later times with Cremophor as the vehicle. An interesting exception was that after 7 and 14 days postinjection in Tween, the levels of dye found in testes were six- to seven-fold higher than those found after Cremophor delivery. Levels of dye were very low or not detectable in the brain. Optimal parameters for PDT of tumors with this novel photosensitizer are clearly time- and vehicle-dependent, and future PDT studies will need to incorporate these modulators.

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Intravesical Instillation with Adriamycin + Tween 80 in Patients with Superficial Bladder Tumors

Cited by 12 publications

References 6 publications

Intravesical Instillation of Adriamycin: Influence on Bladder Capacity

Intravesical Instillation of Adriamycin: Influence on Bladder Capacity

Thiotepa versus Adriamycin versus Cis-Platinum in the Intravesical Prophylaxis of Superficial Bladder Tumors

Effect of Delivery System on the Pharmacokinetics and Tissue Distribution of bis(Di‐lsobutyl Octadecylsiloxy)Silicon 2,3‐Naphthalocyanine (isoBOSINC), a Photosensitizer for Tumor Therapy

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