Lobomycosis Successfully Treated with Posaconazole

Abstract

Abstract. Lobomycosis is a chronic subcutaneous mycosis for which no standard treatment is available to date. We describe a patient in Peru with lobomycosis on the left earlobe that was successfully treated with posaconazole for 27 months. No evidence of recurrence was observed after five years of follow-up.Lobomycosis (lacaziosis) is a chronic subcutaneous disease caused by the fungus Lacazia loboi, which is reported mainly in Central and South America, mostly from Brazil and Colombia.

Subcutaneous mycoses in Peru: a systematic review and meta‐analysis for the burden of disease

“…The findings of this review should assist clinicians in making decisions, providing health education, and may also help in surveillance and diagnosis about the implementation of screening and management programs of this disease in hyperendemic and non‐hyperendemic areas. Previous “non‐systematic” reviews had reported sporotrichosis as endemic in 13 of the 25 regions we studied, with lobomycosis, chromoblastomycosis, and subcutaneous phaeohyphomycosis being rare in Peru . In our study, we found that, among the subcutaneous mycoses found in Peru, sporotrichosis was the most common and mainly located throughout highlands of Peru (Apurimac, Cajamarca, La Libertad, and Cusco).…”

“…1). [16][17][18][19][20][21][22][23][24][25][26][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] Distribution of subcutaneous mycoses in Peru Studies were also analyzed according to the altitude of the geographical regions. A greater number of cases were reported in regions found at higher altitudes ( Fig.…”

“…In this meta‐analysis, all cases of lobomycosis were reported from the Peruvian jungle in Madre de Dios, a poorly developed and low‐altitude (183–500 m) region which has a tropical climate with an average temperature range between 10–27 °C and periods of intense precipitation of 1000 mm of rainfall per year . It is likely these conditions favor the growth and spread of the fungus Lacazia loboi, given that this pathogen is found in forest areas with dense vegetation and large rivers, with intense precipitations of 2000 mm of rainfall per year, an average temperature of 24 °C and relative humidity of 75% .…”

“…Cases of lobomycosis, chromoblastomycosis, and subcutaneous phaeohyphomycosis in PeruRam ırezSoto and Malaga Subcutaneous mycoses in Peru Tropical Medicine Rounds 25 regions we studied,17,[20][21][22]26,45 with lobomycosis, chromoblastomycosis, and subcutaneous phaeohyphomycosis being rare in Peru 23,24,[37][38][39][40]. In our study, we found that, among the subcutaneous mycoses found in Peru, sporotrichosis was the most common and mainly located throughout highlands of Peru (Apurimac,…”

Fungal Infections of Implantation (Chromoblastomycosis, Mycetoma, Entomophthoramycosis, and Lacaziosis)

“…Clofazimine combined with itraconazole has been reported to produce clinical and histopathological remission of the disease in one treated patient after 1 year of therapy [92]. In another case report, posaconazole achieved reduction of the size of lesions in one patient treated with this drug [93].…”