Lobarin from the Sumatran lichen, Stereocaulon halei

Ismed, Friardi; Dévéhat, Françoise Lohézic-Le; Delalande, Olivier; Sinbandhit, Sourisak; Bakhtiar, Amri; Boustié, Joël

doi:10.1016/j.fitote.2012.09.025

Cited by 27 publications

(20 citation statements)

References 19 publications

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“…Likewise, no HMBC ▶ crosspeak could lead to straightforwardly assign the location of this group, as could be expected due to the fully substituted environment of this function in 4. While such direct evidence could not be obtained, the diphenylether scaffold of 4 was supported by the chemical shift of C-7 which lies in the typical range observed for methyl ester-substituted diphenylethers (165-167 ppm) [18,31,32] while the C-7 oxepinone signal upfield shifts to the 160-162 range [23,[32][33][34]. Likewise, the chemical shift of C-4′ in diphenylethers is reported to be 4 ppm downfield that of the equivalent C-5a position of depsidones [18,31,32], as reported here (▶ Table 1).…”

Section: Resultsmentioning

confidence: 98%

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

et al. 2020

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Three new depsidones, parmosidones F – G (1 – 2), and 8′-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A – C (4 – 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics were assayed for their α-glucosidase inhibitory activities. Newly reported benzylated depsidones 1 and 2 in particular inhibited α-glucosidase with IC50 values of 2.2 and 4.3 µM, respectively, and are thus more potent than the positive control, acarbose.

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Section: Resultsmentioning

confidence: 98%

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

et al. 2020

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“…Atranorin (1) -colorless needles; mp 191-192 °C (undepressed in admixture with reference compound; Spectral data were also identical to that of reference previosly isolated from Stereocaulon halei [27].…”

Section: Isolation Of Major Constituents Of S Graminosummentioning

confidence: 62%

Screening of some Sumatran medicinal plants and selected secondary metabolites for their cytotoxic potential against MCF-7 and HSC-3 cell lines

Husnunnisa¹,

Ismed²,

Bakhtiar³

et al. 2019

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How to cite this article: Husnunnisa, Ismed F, Taher M, Ichwan SJA, Bakhtiar A, Arbain D. Screening of some Sumatran medicinal plants and selected secondary metabolites for their cytotoxic potential against MCF-7 and HSC-3 cell lines. J Res Pharm. 2019; 23(4): 770-776. ABSTRACT:In continuation of our study of Sumatran plants and bioactivities of their constituents particularly their cytotoxic activities, we re-extracted lichen Stereocaulon graminosum Schaer (Stereocaulaceae), and isolated atranorin (1) and stictic acid (4).. These isolated compounds have been tested for their cytotoxic activities against human breast adenocarcinoma cancer cell (MCF-7) and human oral squamous carcinoma cancer cell (HSC-3) using MTT assay with a slight modification. Some methanolic extracts of the leaves of Elephantopus scaber, Piper betle, Andrographis paniculata, rhizomes of Boesenbergia pandurata, Alpinia galanga, Kaempferia galanga and isolated compounds; ethyl haematommate (2), olivatolic acid (3), deoxyelephantopin (5), andrographolide (6), hydroxychavicol (7), eugenol (8), curcumin (9), pinostrobin (10), pinocembrin (11), alpinetin (12), α-mangostin (13), angiopteroside (14), and stevioside (15) from Sumatran traditional medicinal plants have also been tested.

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“…All chemicals (acetonitrile, chloroform, methanol, tetrahydrofuran, toluene, ethyl acetate, formic acid) were of analytical reagent grade and were purchased from Sigma (St Quentin-Fallavier, France). Authentic atranorin, lobaric acid and stictic acid, (+)-usnic acid were previously isolated from Stereocaulon halei 28 and Usnea articulata 29 , respectively. Norstictic acid, fumarprotocetraric acid and perlatolic acid were available in the laboratory under the codes JB/A/036, JB/A/003a, JB/A/130, respectively.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

Chemotaxonomic discrimination of lichen species using an infrared chalcogenide fibre optic sensor: a useful tool for on-field biosourcing

et al. 2016

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Lobarin from the Sumatran lichen, Stereocaulon halei

Cited by 27 publications

References 19 publications

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

Screening of some Sumatran medicinal plants and selected secondary metabolites for their cytotoxic potential against MCF-7 and HSC-3 cell lines

Chemotaxonomic discrimination of lichen species using an infrared chalcogenide fibre optic sensor: a useful tool for on-field biosourcing

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