Loading and release of cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid

Abstract

Background Recently, the development of nanocarriers and the improvement of their biochemical properties have became of great importance. Single-walled carbon nanotubes (SWCNT) have many applications in drug delivery systems (DDS) as a common carbon-based structure. In the current work, the penetration, co-loading, and co-release of Doxorubicin (DOX) and Paclitaxel (PAX), as two cancer chemotherapy agents, were investigated using a novel modified copolymer with functionalized SWCNT. Results This study proposes a dual-responsive smart carrier that is sensitive to pH and temperature. The carrier consists of functionalized SWNT and Dimethyl acrylamide-trimethyl chitosan (DMAA-TMC) grafting on SWCNT. This suggested carrier was investigated by utilizing molecular simulations. Interaction energies between DOX, PAX, and carrier as well as the affinity of drugs to the nanocarrier were studied. The energy analysis of drug release and adsorption presented that DOX and PAX delivery using this carrier is selective and sensitive at healthy and cancerous conditions. The attraction of DMAA-TMC, as a biodegradable and biocompatible copolymer, with SWCNT showed that degradation mechanism in acidic environment deformed the copolymer. This leads to a smart release mechanism in an acidic cancerous tissue. Additionally, it improves hydrophilicity, optimum nano-particle size, and cell cytotoxicity concerns. Conclusions The simulation results manifested a significant contribution of DMAA-TMC in the adsorption and release of cancer chemotherapy drugs in normal and neoplastic tissues. The interaction of copolymer also improves the biocompatibility and biodegradability of the SWCNT. Smart drug delivery carrier can be a valuable nanohybrid for loading, transporting, and releasing of cancer chemotherapy drugs. Graphical abstract

Metal-Organic Frameworks (MOFs); A Promising Approach to Combat SARS-CoV-2

“…Then the les were saved in pdbqt format. Then the docking process of spike protein and ACE2 was performed using the program autodock_vina_1_1_2_linux_x86 43,44 .…”

A computational study of metal–organic frameworks (MOFs) as potential nanostructures to combat SARS-CoV-2

“…Then the files were saved in pdbqt format. Then the docking process of spike protein and ACE2 was performed using the program autodock_vina_1_1_2_linux_x86 41 , 42 .…”

Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications

“…Chitosan is a polysaccharide that supports many living organisms, and it is used in drug delivery because of its properties, such asefflux pump inhibition, permeation enhancement, transfection, in situ gelations, mucoadhesion, and controlled drug release [ 57 , 58 , 59 , 60 ].The pH- and temperature-responsive nanohybrid carriers consisting of SWNT and DMAA-TMC (Dimethyl acrylamide–trimethyl chitosan) copolymer grafting on SWCNT were designed and tested for their drug release potentials using molecular dynamic simulation. The carriers loaded with paclitaxel and doxorubicin showed a pH-responsive drug release in the acidic pH in the simulation studies [ 61 ]. Jia et al prepared FA-containing chitosan oligosaccharide-grafted disulfide-containing polyethyleneimine copolymer-based silica nanohybrids against multidrug-resistant breast cancer cells.…”