LncRNA ANRIL is up-regulated in nasopharyngeal carcinoma and promotes the cancer progression via increasing proliferation, reprograming cell glucose metabolism and inducing side-population stem-like cancer cells

Zou, Zhen; Ma, C; Medoro, Lorraine; Chen, Lili; Wang, Bin; Gupta, Roohi; Liu, Ting; Yang, Xian; Chen, Tian Tian; Wang, Ruo Zhen; Zhang, Wen Jie; Li, Pin Dong

doi:10.18632/oncotarget.11437

Cited by 131 publications

(103 citation statements)

References 48 publications

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“…It was reported that ANRIL silencing repressed the proliferation of NPC cells. 16 In our study, the results of MTT assay also revealed that ANRIL knockdown led to the proliferation inhibition of NPC cells ( Fig. 3C and 3D).…”

Section: Anril Knockdown Inhibits Proliferation Of Npc Cellssupporting

confidence: 71%

“…[13][14][15] Moreover, a recent study demonstrated that ANRIL was overexpressed in NPC cell lines and NPC tissues and promoted NPC progression through improving cell proliferation, reprograming cell glucose metabolism and inducing side-population stem-like cancer cells. 16 Growing evidence suggests that ANRIL functions as a fatal oncogene in many cancers, however, limited knowledge is available concerning whether lncRNA ANRIL affects the radiosensitivity of NPC.…”

Section: Introductionmentioning

confidence: 99%

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Downregulation of lncRNA ANRIL inhibits proliferation, induces apoptosis, and enhances radiosensitivity in nasopharyngeal carcinoma cells through regulating miR-125a

Jiang

2017

Cancer Biology & Therapy

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Increasing evidence demonstrated that long non-coding RNA ANRIL serves as a fatal oncogene in many cancers, including nasopharyngeal carcinoma (NPC). However, little is known whether ANRIL regulated NPC cell radioresistance. Quantitative real-time PCR (qRT-PCR) was performed to examine the expression of lncRNA ANRIL and miR-125a in NPC tissues and cell lines. MTT assay was conducted to measure the cell viability of CNE2 and HONE1 cells. The apoptotic rate of CNE2 and HONE1 cells was determined by flow cytometry analysis. Colony survival was determined by clonogenic assay. Luciferase reporter assay was performed to verity the direct target of miR-125a. LncRNA ANRIL was evidently elevated in NPC tissues and cell lines. ANRIL inhibition suppressed proliferation, induced apoptosis, and enhanced radiosensitivity in NPC. Moreover, ANRIL could negatively modulate miR-125a expression. Furethermore, ANRIL upregulation reserved the inhibited proliferation, induced apoptosis, and enhanced radiosensitivity triggered by miR-125a overexpression. The expression of lncRNA ANRIL was upregulated in NPC tissues and cells. Moreover, knockdown of ANRIL repressed proliferation, promoted apoptosis, and improved radiosensitivity in NPC via functioning as a miR-125a sponge.

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Section: Anril Knockdown Inhibits Proliferation Of Npc Cellssupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Downregulation of lncRNA ANRIL inhibits proliferation, induces apoptosis, and enhances radiosensitivity in nasopharyngeal carcinoma cells through regulating miR-125a

Jiang

2017

Cancer Biology & Therapy

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“…LncRNA ANRIL, which encodes a 3834-nt RNA that contains 19 exons at the antisense orientation of the INK4B-ARF-INK4A gene cluster, could promote NPC progression by increasing cell proliferation and transformation, reprogramming cell glucose metabolism, and inducing side-population stem-like cancer cells. This may partially account for ANRIL-induced stem-like NPC cells and tumorigenesis [73]. In addition, knockdown of ANRIL repressed tumorigenicity and enhanced DDP-induced cytotoxicity through regulating microRNA let-7a in NPC cells, this provided a promising therapeutic strategy for NPC patients [54].…”

Section: Oncogenic Lncrnasmentioning

confidence: 99%

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

Hann²

2018

Cell Physiol Biochem

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Nasopharyngeal carcinoma (NPC) is one of the most common cancers originating in the nasopharynx and occurring at high frequency in South-eastern Asia and North Africa. Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNA molecules and key regulators of developmental, physiological, and pathological processes in humans. Emerging studies have shown that lncRNAs play critical roles in tumorgenicity and cancer prognosis. With the development of deep sequencing analyses, an extensive amount of functional lncRNAs have been discovered in nasopharyngeal carcinoma tissues and cell lines. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of NPC are not fully understood. In this review, we briefly illustrate the concept, identification, functional characterization, and summarize recent advancements of biological functions of lncRNAs with heterogeneous mechanistic characterization and their involvement in NPC. Then, we describe individual lncRNAs that have been associated with tumorgenesis, growth, invasion, cancer stem cell differentiation, metastasis, drug resistance and discuss the strategies of their therapeutic manipulation in NPC. We also review the emerging insights into the role of lncRNAs and their potential as biomarkers and therapeutic targets for novel treatment paradigms. Finally, we highlight the up-to-date of clinical information involving lncRNAs and future directions in the linking lncRNAs to potential gene therapies, and how modifications of lncRNAs can be exploited for prevention and treatment of NPC.

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“…LncRNAs plays crucial roles on several systems and might be critical to various types of known cancer genes [8, 10-12]. It has been reported that lncRNAs function as important regulator in NPC.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA LOC100129148 functions as an oncogene in human nasopharyngeal carcinoma by targeting miR-539-5p

Sun

Peng

Chen

et al. 2017

Aging

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Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression, including human nasopharyngeal carcinoma (NPC). The correlation between lncRNAs expression and NPC development has not been well identified in the recent literature. Recently, high-through put analysis reveals that LOC100129148 is highly expressed in NPC. However, whether the aberrant expression of LOC100129148 in NPC is corrected with tumorigenesis or prognosis has not been investigated. Herein, we identified that LOC100129148 was up-regulated in NPC tissues and cell lines, and higher expression of LOC100129148 resulted in a markedly poorer survival time. Over-expressed LOC100129148 favored, but silenced LOC100129148 hampered cell proliferation in NPC cells. Additionally, LOC100129148 enhanced the KLF12 expression through functioning as a competitive ‘sponge’ for miR-539-5p. Thus, our study reports a novel mechanism underlying NPC carcinogenesis, and provides a potential novel diagnosis and treatment biomarker for NPC.

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LncRNA ANRIL is up-regulated in nasopharyngeal carcinoma and promotes the cancer progression via increasing proliferation, reprograming cell glucose metabolism and inducing side-population stem-like cancer cells

Cited by 131 publications

References 48 publications

Downregulation of lncRNA ANRIL inhibits proliferation, induces apoptosis, and enhances radiosensitivity in nasopharyngeal carcinoma cells through regulating miR-125a

Downregulation of lncRNA ANRIL inhibits proliferation, induces apoptosis, and enhances radiosensitivity in nasopharyngeal carcinoma cells through regulating miR-125a

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

Long non-coding RNA LOC100129148 functions as an oncogene in human nasopharyngeal carcinoma by targeting miR-539-5p

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