Long non-coding RNA LOC100129148 functions as an oncogene in human nasopharyngeal carcinoma by targeting miR-539-5p

Sun, Kai-Yu; Peng, Tao; Chen, Zhe; Song, Peng; Zhou, Xuhong

doi:10.18632/aging.101205

Cited by 48 publications

(32 citation statements)

References 44 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies have shown that lncRNAs acts as a ceRNA to sponge microRNAs to modulate the expression level of microRNA targets in many biologic process. 6,[22][23][24][25] As we have mentioned that LOC100129148 promotes nasopharyngeal carcinoma progression by targeting miR-539-5p, 9 lncRNA EWSAT1 promotes nasopharyngeal cancer development by targeting miR-326/-330-5p 10 and LncRNA 00858 acts as an ceRNA of miR-422a in non-samll cell lung cancer. 11 In this study, we notified that the expression level of microRNA-26a was negatively correlated with the expression level of DLX6-AS1 in RCC tissue samples.…”

Section: Discussionmentioning

confidence: 99%

“…5 It has been wildly investigated that lncRNAs modulate many types of tumor progression. [6][7][8] For example, lncRNA LOC100129148 and EWSAT1 have been reported to act as oncogenic role in nasopharyngeal carcinoma, 9,10 lncRNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer 11 and Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer. 12 It also has been reported that high DLX6-AS1 expression levels were significantly associated with both histological differentiation and TNM stage of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long noncoding RNA DLX6-AS1 promotes renal cell carcinoma progression via miR-26a/PTEN axis

Zeng

et al. 2017

Cell Cycle

View full text Add to dashboard Buy / Rent full text

Recently, long non-coding RNAs (lncRNAs) have emerged as new gene regulators and prognostic markers in several types of cancer, including renal cell carcinoma (RCC). In this study, we identified an upregulated lncRNA, DLX6-AS1, in RCC tumor tissues compared with normal kidney tissues. Our data suggested that DLX6-AS1 promoted RCC cell growth and tumorigenesis via targeting miR-26a. In addition, we observed that PTEN overexpression restored the renal cancer cell growth and also rescued the RCC tumorigenesis. In summary, we conclude that DLX6-AS1 promotes renal cell carcinoma development via regulation of miR-26a/PTEN axis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA DLX6-AS1 promotes renal cell carcinoma progression via miR-26a/PTEN axis

Zeng

et al. 2017

Cell Cycle

View full text Add to dashboard Buy / Rent full text

show abstract

“…These suggested that KLF12 was a direct target of miR-216a-5p. LncRNAs can play an essential role in tumorigenesis (C. H. Li & Chen, 2013;K. Y.…”

Section: Klf12 Was a Direct Target Of Mir-216a-5pmentioning

confidence: 99%

DANCR contributed to hepatocellular carcinoma malignancy via sponging miR‐216a‐5p and modulating KLF12

Wang

Zhang³

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Buy / Rent full text

Long noncoding RNA (lncRNA) differentiation antagonizing nonprotein coding RNA (DANCR) has been identified as an oncogene in several cancers. However, the biological function and role of DANCR in hepatocellular carcinoma (HCC) remain unclear. Our current study aimed to investigate the detailed mechanism of DANCR in HCC. We found that DANCR was significantly upregulated in HCC cell lines in comparison to LO2 cells. Then, we observed that knockdown of DANCR could greatly inhibit Huh7 and HepG2 cell proliferation. In addition, HCC cell apoptosis was increased by silence of DANCR and meanwhile, cell cycle progression was blocked in G1 phase. Apart from these, downregulation of DANCR repressed HCC cell migration and invasion ability obviously. As predicted by the bioinformatics analysis, microRNA‐216a‐5p (miR‐216a‐5p) could serve as a direct target of DANCR. MiR‐216a‐5p has been reported to be involved in many cancers. Here, the correlation between miR‐216a‐5p and DANCR was confirmed using dual‐luciferase reporter assay and radioimmunoprecipitation assay. Subsequently, Kruppel‐like factor 12 (KLF12) exerts an important role in different tumor types. KLF12 can function as a downstream target of miR‐216a‐5p. Finally, the in vivo experiments were used and the data proved that DANCR also strongly suppressed HCC tumor growth in vivo via targeting miR‐216a‐5p and KLF12. In conclusion, our study indicated that DANCR might provide a new perspective for HCC treatment.

show abstract

“…Overexpressed LOC100129148 induced, but silenced LOC100129148 hampered cell proliferation in NPC cells. Mechanistically, LOC100129148 enhanced the expression of KLF12, a member of the Kruppel-like family of transcription factors, through competitive ‘sponge’ for miR-539-5p to stimulate growth of NPC cells [102]. NPC patients with high lncRNA LINC01420 expression level showed poor overall survival as well, and knockdown LINC01420 inhibited NPC cell migration and invasion in vitro [103].…”

Section: Oncogenic Lncrnasmentioning

confidence: 99%

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

Wu¹,

Hann²

2018

Cell Physiol Biochem

View full text Add to dashboard Buy / Rent full text

Nasopharyngeal carcinoma (NPC) is one of the most common cancers originating in the nasopharynx and occurring at high frequency in South-eastern Asia and North Africa. Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNA molecules and key regulators of developmental, physiological, and pathological processes in humans. Emerging studies have shown that lncRNAs play critical roles in tumorgenicity and cancer prognosis. With the development of deep sequencing analyses, an extensive amount of functional lncRNAs have been discovered in nasopharyngeal carcinoma tissues and cell lines. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of NPC are not fully understood. In this review, we briefly illustrate the concept, identification, functional characterization, and summarize recent advancements of biological functions of lncRNAs with heterogeneous mechanistic characterization and their involvement in NPC. Then, we describe individual lncRNAs that have been associated with tumorgenesis, growth, invasion, cancer stem cell differentiation, metastasis, drug resistance and discuss the strategies of their therapeutic manipulation in NPC. We also review the emerging insights into the role of lncRNAs and their potential as biomarkers and therapeutic targets for novel treatment paradigms. Finally, we highlight the up-to-date of clinical information involving lncRNAs and future directions in the linking lncRNAs to potential gene therapies, and how modifications of lncRNAs can be exploited for prevention and treatment of NPC.

show abstract

Long non-coding RNA LOC100129148 functions as an oncogene in human nasopharyngeal carcinoma by targeting miR-539-5p

Cited by 48 publications

References 44 publications

Long noncoding RNA DLX6-AS1 promotes renal cell carcinoma progression via miR-26a/PTEN axis

Long noncoding RNA DLX6-AS1 promotes renal cell carcinoma progression via miR-26a/PTEN axis

DANCR contributed to hepatocellular carcinoma malignancy via sponging miR‐216a‐5p and modulating KLF12

Functions and Roles of Long-Non-Coding RNAs in Human Nasopharyngeal Carcinoma

Contact Info

Product

Resources

About