Lnc<scp>RNA</scp>‐regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of lnc<scp>RNA</scp>s in Early Spontaneous Abortion

Wang, Hong; Cao, Qingying; Ge, Jun; Liu, Chunmiao; Ma, Yanhong; Meng, Yuciu; Wang, Yuxin; Zhao, Xiaoli; Liu, Ru; Li, Caixia; Wang, Yu; Zhong, Julia Li; Ju, Weina; Jenkins, Edmund C.; Brown, W. Ted; Zhong, Nanbert

doi:10.1111/aji.12275

Cited by 56 publications

(60 citation statements)

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“…In our previous study, lncRNAs that are differentially expressed in human placentas delivered from PPROM and sPTL were found to be involved in more than 20 functional pathways (Luo et al, 2013). The patterns of differentially expressed lncRNAs and pathways identified from placentas of PPROM and sPTL were similar to those we observed in our study of human miscarriages (Wang et al, 2014) and of a viral-infected mouse model (Pan et al, 2015), suggesting that deregulation and dysfunction of the ubiquitin-proteasome-collagen (CUP) pathway may be one of the pathogenic mechanisms underlying the adverse outcomes of pregnancies, including PPROM.…”

Section: Introductionsupporting

confidence: 87%

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Ubiquitin-Proteasome-Collagen (CUP) Pathway in Preterm Premature Rupture of Fetal Membranes

et al. 2017

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Spontaneous preterm birth (sPTB) occurs before 37 gestational weeks, with preterm premature rupture of the membranes (PPROM) and spontaneous preterm labor (sPTL) as the predominant adverse outcomes. Previously, we identified altered expression of long non-coding RNAs (lncRNAs) and message RNAs (mRNAs) related to the ubiquitin proteasome system (UPS) in human placentas following pregnancy loss and PTB. We therefore hypothesized that similar mechanisms might underlie PPROM. In the current study, nine pairs of ubiquitin-proteasome-collagen (CUP) pathway–related mRNAs and associated lncRNAs were found to be differentially expressed in PPROM and sPTL. Pathway analysis showed that the functions of their protein products were inter-connected by ring finger protein. Twenty variants including five mutations were identified in CUP-related genes in sPTL samples. Copy number variations were found in COL19A1, COL28A1, COL5A1, and UBAP2 of sPTL samples. The results reinforced our previous findings and indicated the association of the CUP pathway with the development of sPTL and PPROM. This association was due not only to the genetic variation, but also to the epigenetic regulatory function of lncRNAs. Furthermore, the findings suggested that the loss of collagen content in PPROM could result from degradation and/or suppressed expression of collagens.

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Section: Introductionsupporting

confidence: 87%

“…qRT-PCR was employed for validation, as reported earlier (Luo et al, 2013; Wang et al, 2014; Pan et al, 2015). In the discovery study, fold changes >2 and p < 0.05 were set as cut-offs and were considered significant.…”

Section: Methodsmentioning

confidence: 99%

Ubiquitin-Proteasome-Collagen (CUP) Pathway in Preterm Premature Rupture of Fetal Membranes

et al. 2017

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“…Some studies (Romero et al 2004;Deftereou et al 2012;Cicinelli et al 2014;Wang et al 2014;Ahmed et al 2015) have noted chronic and systemic inflammation to play an important role in risk of abortion, but whence abortion etiology is multifactorial, this mechanism will not be held accountable for all…”

Section: Discussionmentioning

confidence: 99%

“…Chronic inflammation and serum levels of C-reactive protein (CRP) has been shown to play a role in abortion in some studies (Romero et al 2004;Deftereou et al 2012;Cicinelli et al 2014;Wang et al 2014;Ahmed et al 2015) and the inconsistency in results underlines that understanding the causes of spontaneous abortion is D r a f t methodologically challenging. On the other hand, it is not clear that how much of an effect nutrition or natural changes during pregnancy affect delivery status.…”

Section: Introductionmentioning

confidence: 99%

Association between Maternal Dietary Inflammatory Index (DII) and abortion in Iranian women and validation of DII with serum concentration of inflammatory factors: case-control study

Vahid

Shivappa

Hekmatdoost

et al. 2017

Appl. Physiol. Nutr. Metab.

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“…Furthermore, the maternal auto-antibodies profile, which is epigenetically altered by microbial infection, can be adaptive, which may form the basis for autism development in early life [196]. Recent studies show that long non-coding RNAs (lncRNAs) are differentially expressed and regulate various infection and inflammatory pathways, leading to spontaneous abortions [197,198]. …”

Section: Infectionmentioning

confidence: 99%

Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring

Banik

Kandilya

Ramya

et al. 2017

Genes

102

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It is well established that the regulation of epigenetic factors, including chromatic reorganization, histone modifications, DNA methylation, and miRNA regulation, is critical for the normal development and functioning of the human brain. There are a number of maternal factors influencing epigenetic pathways such as lifestyle, including diet, alcohol consumption, and smoking, as well as age and infections (viral or bacterial). Genetic and metabolic alterations such as obesity, gestational diabetes mellitus (GDM), and thyroidism alter epigenetic mechanisms, thereby contributing to neurodevelopmental disorders (NDs) such as embryonic neural tube defects (NTDs), autism, Down’s syndrome, Rett syndrome, and later onset of neuropsychological deficits. This review comprehensively describes the recent findings in the epigenetic landscape contributing to altered molecular profiles resulting in NDs. Furthermore, we will discuss potential avenues for future research to identify diagnostic markers and therapeutic epi-drugs to reverse these abnormalities in the brain as epigenetic marks are plastic and reversible in nature.

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LncRNA‐regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of lncRNAs in Early Spontaneous Abortion

Abstract: Infection and inflammation pathways regulated by lncRNAs were determined as the predominant pathogenetic factors underlying the SA. Finding that antisense lncRNAs have been either up- or down-regulated suggests that they may have both cis- and trans-regulations.

Cited by 56 publications

References 35 publications

Ubiquitin-Proteasome-Collagen (CUP) Pathway in Preterm Premature Rupture of Fetal Membranes

Ubiquitin-Proteasome-Collagen (CUP) Pathway in Preterm Premature Rupture of Fetal Membranes

Association between Maternal Dietary Inflammatory Index (DII) and abortion in Iranian women and validation of DII with serum concentration of inflammatory factors: case-control study

Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring

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