Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring

Banik, Avijit; Kandilya, Deepika; Ramya, Seshadri; Stünkel, Walter; Chong, Yap Seng; Dheen, S. Thameem

doi:10.3390/genes8060150

Cited by 99 publications

(77 citation statements)

References 226 publications

(248 reference statements)

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“…Zika virus, for example, exerts a change in the infant RNA through methylation changes . Infants exposed to maternal infection and febrile illness have more copy number variants and higher rates of autism spectrum disorder …”

Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

“…Some proposed mechanisms for the programming effects of hyperglycemia include increased oxidative stress and accumulation of reactive oxidative species, which alter DNA methylation. Neural stem cell histone acetylation alterations and changes in microRNA are also seen in fetal exposure to hyperglycemia . Maternal obesity is associated with HPA axis changes and increased inflammatory markers.…”

Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

“…Maternal obesity is associated with HPA axis changes and increased inflammatory markers. Decreased DNA methylation is seen in pregnancies of females with high body mass indices . In addition to hormonal influences of the HPA axis, the effect of hypothyroidism on the developing fetus has long been documented.…”

Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

“…14 Infants exposed to maternal infection and febrile illness have more copy number variants and higher rates of autism spectrum disorder. [15][16][17] Maternal hormonal and metabolic variations exert modifications in fetal development through a number of mechanisms. Hyperglycemia of maternal gestational diabetes is a known teratogen, causing neural tube defects and neurodevelopmental disorders.…”

Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

“…Neural stem cell histone acetylation alterations and changes in microRNA are also seen in fetal exposure to hyperglycemia. 17 Maternal obesity is associated with HPA axis changes and increased inflammatory markers. Decreased DNA methylation is seen in pregnancies of females with high body mass indices.…”

Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

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Environmental influences on health and development: nutrition, substance exposure, and adverse childhood experiences

Gentner

Leppert

2019

Develop Med Child Neuro

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Scientific advances over the last century have generated compelling evidence of the primary and secondary effects of gestational, infant, and childhood conditions. These early environmental influences have the potential not only to impact an individual's health outcomes, such as heart disease, type 2 diabetes, and cancer, but also to confer various protections and risks to that individual's descendants. The immediate and extended ramifications of early environmental exposure bring an understanding of epidemiological impact on disease states and a hope for prevention. This review highlights the contributions of several key population studies and briefly explores specific environmental influences, including nutritional deficiencies, exposure to substances and infections, and adverse childhood experiences. Mechanisms of these influences (e.g. stress and epigenetics) are discussed, as well as possible means of mitigating their negative consequences. What this paper adds Substance exposures in utero are associated with epigenetic changes and negative outcomes. Adverse childhood experiences in early childhood can induce HPA and epigenetic changes.

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Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

Section: Influences Mechanisms and Mitigatorsmentioning

confidence: 99%

See 3 more Smart Citations

Environmental influences on health and development: nutrition, substance exposure, and adverse childhood experiences

Gentner

Leppert

2019

Develop Med Child Neuro

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Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence

et al. 2020

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Prenatal maternal diet is a critical factor in offspring neurodevelopment. Emerging evidence suggests that prenatal diet may also play a role in the etiology autism spectrum disorder (ASD). This review summarizes studies published in English that examined prenatal nutrients or maternal diet in association with ASD from PubMed as of July 2020. Thiry-six studies from nine countries were included in this systematic review; these focused on multivitamin (n = 5), prenatal vitamin (n = 3), folic acid (FA; n = 14), Vitamin D (n = 11), polyunsaturated fatty acid or fish/supplement intake (n = 7), iron (n = 3), Vitamin B12 (n = 1), calcium (n = 1), magnesium (n = 1), and broad maternal dietary habits (n = 3). Overall, higher or moderate intake of prenatal/multivitamin, FA, and Vitamin D was associated with reductions in odds of ASD, though results have not been uniform and there is a need to clarify differences in findings based on biomarkers versus reported intake. Evidence was inconclusive or insufficient for other nutrients. Differences in the timing and measurement of these dietary factors, as well as potential residual confounding, may contribute to existing discrepancies. Key areas for future research to better understand the role of maternal diet in ASD include the need to address potential critical windows, examine the combined effect of multiple nutrients, and consider interactions with genetic or environmental factors.

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The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder

et al. 2021

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Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011–2012. We also obtained self‐reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non‐smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine‐defined smoking (≥3.08 ng/ml vs. <3.08 ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self‐reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. Lay Summary This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke.

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Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring

Cited by 99 publications

References 226 publications

Environmental influences on health and development: nutrition, substance exposure, and adverse childhood experiences

Environmental influences on health and development: nutrition, substance exposure, and adverse childhood experiences

Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence

The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder

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