2017
DOI: 10.3390/genes8060150
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Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring

Abstract: It is well established that the regulation of epigenetic factors, including chromatic reorganization, histone modifications, DNA methylation, and miRNA regulation, is critical for the normal development and functioning of the human brain. There are a number of maternal factors influencing epigenetic pathways such as lifestyle, including diet, alcohol consumption, and smoking, as well as age and infections (viral or bacterial). Genetic and metabolic alterations such as obesity, gestational diabetes mellitus (GD… Show more

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Cited by 94 publications
(68 citation statements)
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References 225 publications
(248 reference statements)
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“…Zika virus, for example, exerts a change in the infant RNA through methylation changes . Infants exposed to maternal infection and febrile illness have more copy number variants and higher rates of autism spectrum disorder …”
Section: Influences Mechanisms and Mitigatorsmentioning
confidence: 99%
See 4 more Smart Citations
“…Zika virus, for example, exerts a change in the infant RNA through methylation changes . Infants exposed to maternal infection and febrile illness have more copy number variants and higher rates of autism spectrum disorder …”
Section: Influences Mechanisms and Mitigatorsmentioning
confidence: 99%
“…Some proposed mechanisms for the programming effects of hyperglycemia include increased oxidative stress and accumulation of reactive oxidative species, which alter DNA methylation. Neural stem cell histone acetylation alterations and changes in microRNA are also seen in fetal exposure to hyperglycemia . Maternal obesity is associated with HPA axis changes and increased inflammatory markers.…”
Section: Influences Mechanisms and Mitigatorsmentioning
confidence: 99%
See 3 more Smart Citations