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Herrero–Vanrell, R.

doi:10.1023/a:1026464124412

Cited by 78 publications

(13 citation statements)

References 15 publications

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“…A few other studies have also been conducted in the areas of detection and treatment of human papilloma virus, human rotavirus and Japanese encephalitis virus. Further, it is interesting to note that the majority of studies use polymeric systems such as polyethylene glycol (PEG) [11], poly-Lactic-co-glycolic acid (PLGA) [12], and liposomes [8] for the drug delivery systems. While the use of metal nanoparticles have been strictly restricted to gold and silver, metal oxide nanoparticles such as iron oxide (magnetite), zinc oxide (ZnO), and titanium dioxide (TiO 2 ) have been used in the past studies as well.…”

Section: Use Of Nanoparticles In Virologymentioning

confidence: 99%

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Yadavalli

Shukla

2017

Nanomedicine: Nanotechnology, Biology and Medicine

151

111

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Nanotechnology is increasingly playing important roles in various fields including virology. The emerging use of metal or metal oxide nanoparticles in virus targeting formulations shows the promise of improved diagnostic or therapeutic ability of the agents while uniquely enhancing the prospects of targeted drug delivery. Although a number of nanoparticles varying in composition, size, shape, and surface properties have been approved for human use, the candidates being tested or approved for clinical diagnosis and treatment of viral infections are relatively less in number. Challenges remain in this domain due to a lack of essential knowledge regarding the in vivo comportment of nanoparticles during viral infections. This review provides a broad overview of recent advances in diagnostic, prophylactic and therapeutic applications of metal and metal oxide nanoparticles in Human Immunodeficiency Virus, Hepatitis virus, influenza virus and Herpes virus infections. Types of nanoparticles commonly used and their broad applications have been explained in this review.

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Section: Use Of Nanoparticles In Virologymentioning

confidence: 99%

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Yadavalli

Shukla

2017

Nanomedicine: Nanotechnology, Biology and Medicine

151

111

View full text Add to dashboard Cite

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“…For the former, we used poly(lactic- co -glycolic) acid (PLGA), a biodegradable polymer that is well known for its biocompatibility and its ability to control drug-release kinetics. 34–37 For the latter, we used pHEMA, which is not biodegradable. 38,39 Herein, we describe the formulation and characterization of such a drug-eluting contact lens for extended drug zero-order release.…”

mentioning

confidence: 99%

A Drug-Eluting Contact Lens

Ciolino

Hoare

Iwata

et al. 2009

Invest. Ophthalmol. Vis. Sci.

210

149

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Purpose To formulate and characterize a drug-eluting contact lens designed to provide extended, controlled release of a drug. Methods Prototype contact lenses were created by coating PLGA (poly[lactic-co-glycolic acid]) films containing test compounds with pHEMA (poly[hydroxyethyl methacrylate]) by ultraviolet light polymerization. The films, containing encapsulated fluorescein or ciprofloxacin, were characterized by scanning electron microscopy. Release studies were conducted in phosphate-buffered saline at 37°C with continuous shaking. Ciprofloxacin eluted from the contact lens was studied in an antimicrobial assay to verify antimicrobial effectiveness. Results After a brief and minimal initial burst, the prototype contact lenses demonstrated controlled release of the molecules studied, with zero-order release kinetics under infinite sink conditions for over 4 weeks. The rate of drug release was controlled by changing either the ratio of drug to PLGA or the molecular mass of the PLGA used. Both the PLGA and the pHEMA affected release kinetics. Ciprofloxacin released from the contact lenses inhibited ciprofloxacin-sensitive Staphylococcus aureus at all time-points tested. Conclusions A prototype contact lens for sustained drug release consisting of a thin drug-PLGA film coated with pHEMA could be used as a platform for ocular drug delivery with widespread therapeutic applications.

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“…Microspheres provide a sustained-release injectable drug depot formulation that, in some cases, is able to target specific tissues. The microspheres range in size between 1 and 1,000 μm in diameter and are made with either PLA or PLGA polymers (82)(83)(84)(85)(86)(87)(88)(89).…”

Section: Injectable System/particlesmentioning

confidence: 99%

“…Drug release from microspheres depends on several factors such as polymer composition and its molecular weight, drug hydrophilicity, drug loading, as well as microsphere size (60). Furthermore, the drug release rate from small microspheres is faster than larger ones (84).…”

Section: Microspheresmentioning

confidence: 99%

Intraocular Sustained-Release Delivery Systems for Triamcinolone Acetonide

2009

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Abstract. Recently, the use of triamcinolone acetonide (TA) injection has increased dramatically in treatment for several ocular diseases. Among them, macular diseases such as macular edema due to diabetic retinopathy, venous occlusive diseases, ocular inflammation and age-related macular degeneration (AMD) are very common vision threatening disorders and are great challenges to treat. In these types of chronic retinal diseases, repeated intraocular injections of TA are often required which increases the likelihood of complications. In order to achieve sustained-release, maintain therapeutic levels of TA over longer times and reduce frequency of intravitreal injections, researchers are investigating different implantable devices or injectable systems. However, as of yet, there is no sustained-release product for TA available on the commercial market. This review discusses and compares different sustained-release devices or injectable systems that are currently being developed.

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Abstract: The technique of microsphere preparation described resulted in high ganciclovir loading (95%) and prolonged drug release. The ganciclovir formulation behaved similarly before and after the sterilization process.

Cited by 78 publications

References 15 publications

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

A Drug-Eluting Contact Lens

Intraocular Sustained-Release Delivery Systems for Triamcinolone Acetonide

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