A Drug-Eluting Contact Lens

Ciolino, Joseph B.; Hoare, Todd; Iwata, Naomi G.; Behlau, Irmgard; Dohlman, Claes H.; Langer, Róbert; Kohane, Daniel S.

doi:10.1167/iovs.08-2826

Cited by 205 publications

(148 citation statements)

References 44 publications

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“…This results in a requirement for multiple administrations sometimes at 3-4 intervals per hour over a 24 h period often with an initial dose every 5 min for the fi rst 30-60 min. [ 9,10 ] There could be major advantages in the design and use of slow release antimicrobials from a bandage contact lens material as a more effi cient delivery method. [ 11,12 ] Corneal bandage materials include collagen, amniotic membrane-derived materials, and advanced hydrogel polymers.…”

Section: Doi: 101002/adhm201600258mentioning

confidence: 99%

A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens

Gallagher

Alorabi

Wellings

et al. 2016

Adv Healthcare Materials

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A peptide hydrogel with an antimicrobial activity is developed as a bandage contact lens. The antimicrobial activity is enhanced with the addition of the biomolecules penicillin G or poly‐ε‐lysine and is positive against Staphylococcus aureus and Escherichia coli. The lens is also noncytotoxic toward a human corneal epithelial cell line and as a consequence is of great potential as a drug‐eluting bandage lens replacing conventional corneal ulcer treatment.

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Section: Doi: 101002/adhm201600258mentioning

confidence: 99%

A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens

Gallagher

Alorabi

Wellings

et al. 2016

Adv Healthcare Materials

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“…13 Realistically however, strategies such as reducing administered volume, increasing drug dosage and frequency of application and related strategies, although capable of improving drug effectiveness are difficult to achieve in practice. 2,5,7,14,15 Several attempts have been made to harness specific properties of macromolecules (viscosity modification, mucoadhesion and in-situ gelling 11,[16][17][18][19] ) to enhance interaction and retention of the drug with the anterior eye. The marked effect of viscosity increase 5 (0.9% saline < 1% methyl cellulose < 1.4% poly(vinyl alcohol) < petrolatum oil) on the reduction of tear film drainage is illustrated in Figure 1b.…”

Section: Introductionmentioning

confidence: 99%

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Mahomed

Tighe

2014

J Biomater Appl

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The poor retention and efficacy of instilled drops as a means of delivering drugs to the ophthalmic environment is well-recognised. The potential value of contact lenses as a means of ophthalmic drug delivery and consequent improvement of pre-corneal retention is one obvious route to the development of a more effective ocular delivery system. Furthermore, the increasing availability and clinical use of daily disposable contact lenses provides the platform for the development of viable single-day use drug delivery devices based on existing materials and lenses. In order to provide a basis for the effective design of such devices, a systematic understanding of the factors affecting the interaction of individual drugs with the lens matrix is required. Because a large number of potential structural variables are involved it is necessary to achieve some rationalisation of the parameters and physicochemical properties (such as molecular weight, charge, partition coefficients) that influence drug interactions. Ophthalmic dyes and structurally related compounds based on the same core structure were used to investigate these various factors and the way in which they can be used in concert to design effective release systems for structurally different drugs. Initial studies of passive diffusional release form a necessary precursor to the investigation of the features of the ocular environment that over-ride this simple behaviour. Commercially available contact lenses of differing structural classifications were used to study factors affecting the uptake of the surrogate actives and their release under "passive" conditions. The interaction between active and lens material shows considerable and complex structure dependence which is not simply related to equilibrium water content (EWC). The structure of the polymer matrix itself was found to have the dominant controlling influence on active uptake; hydrophobic interaction with the ophthalmic dye playing a major role.3

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“…Many attempts of the delivery device have failed to achieve constant drug release, including conventional soft contact lenses, 'biomimetic' and molecularly imprinted hydrogel contact lenses. [45][46][47] Ciolino et al 48 succeeded in delivering drugs to the eye with zero-order kinetics. The device they designed was a dual polymer system, with one polymer film PLGA containing the test compounds and the other polymer pHEMA used as a component of the contact lenses.…”

Section: Coating Materialsmentioning

confidence: 99%

“…And the rate of drug release can be regulated by changing either the ratio of drug to PLGA or the molecular mass of the PLGA used. 48 Catheters and other indwelling devices such as surgical implant placed inside the human body are prone to bacterial infection, thereby causing serious risk to patients. To circumvent and mitigate local infection for a long period, the surfaces of the graft or device are usually coated with antibiotic-containing composites.…”

Section: Coating Materialsmentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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A Drug-Eluting Contact Lens

Cited by 205 publications

References 44 publications

A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens

A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Recent advances in materials for extended-release antibiotic delivery system

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