LL-37 Exacerbates Local Inflammation in Sepsis-Induced Acute Lung Injury by Preventing Mitochondrial DNA (mtDNA) Degradation-Induced Autophagy

Zuo, Yunlong; Dang, Run; Peng, Hongyan; Wu, Zhiyuan; Yang, Yiyu

doi:10.12659/msm.915298

Cited by 4 publications

(4 citation statements)

References 24 publications

(34 reference statements)

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“…By injecting mice with mtDNA, neutrophils are activated via p38 MAPK to produce excess proinflammatory cytokines, including IL-1β, IL-6, IL-8, MMP-8, and TNF-α, and induce inflammation. 73,74 To date, mtDNA functions in adaptive immunity have been rarely reported. T-cell receptor (TCR) activation triggers mtDNA production.…”

Section: Mitochondrial Dnamentioning

confidence: 99%

“…Similar studies have confirmed the inflammatory nature of mtDNA by demonstrating that mtDNA directly activates various pattern recognition receptors to trigger an inflammatory response. By injecting mice with mtDNA, neutrophils are activated via p38 MAPK to produce excess proinflammatory cytokines, including IL‐1β, IL‐6, IL‐8, MMP‐8, and TNF‐α, and induce inflammation 73,74 …”

Section: Damps and Autoimmune Diseasesmentioning

confidence: 99%

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Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Kang

Liu

Haneef

et al. 2022

Rheumatology & Autoimmunity

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All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage-associated molecular patterns (DAMPs). In addition to well-characterized DAMPs such as high-mobility group box 1 and adenosine triphosphate, studies on new classes of DAMPs have emerged. Here, we review recent reports of a new class of isoprenoid-derived DAMPs, including farnesyl pyrophosphate and geranylgeranyl pyrophosphate, both of which are pivotal metabolic intermediates of the mevalonate pathway. We also explore the roles of old and new DAMPs in autoimmune diseases that result from dysregulated inflammation. The findings highlight that understanding the functional mechanisms of DAMPs is important to enrich the DAMP family and decipher their immunoregulatory mechanisms to provide new therapeutics for the prevention and treatment of autoimmune diseases.

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Section: Mitochondrial Dnamentioning

confidence: 99%

Section: Damps and Autoimmune Diseasesmentioning

confidence: 99%

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Kang

Liu

Haneef

et al. 2022

Rheumatology & Autoimmunity

View full text Add to dashboard Buy / Rent full text

show abstract

Section: Introductionmentioning

confidence: 99%

“…4 In the case of sepsis, various inflammatory factors and mediators are released and activated in large quantities, and the imbalance between inflammatory and anti-inflammatory factors damages lung tissue and promotes the development of ALI/ARDS. 5 Identifying new biomarkers of ALI/ ARDS for early diagnosis and treatment is an important approach to improve the prognosis of patients with sepsis. Studies on the relationship between microRNAs (miRNAs) and tumors have become a hot topic in the medical community.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of miR-155 for acute lung injury/acute respiratory distress syndrome in patients with sepsis

Wang¹,

Yang

Fan

2020

J Int Med Res

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Objective We aimed to investigate the diagnostic value of microRNA-155 (miR-155) for acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) in patients with sepsis. Methods In this prospective study, we used Spearman correlation analysis to investigate relationships between miR-155 expression and inflammatory factors, oxygenation ratio (PaO2/FiO2), and ALI/ARDS score, and used area under the receiver operating characteristic curve (AU-ROC) to evaluate miR-155's diagnostic accuracy for ALI/ARDS in patients with sepsis. Results In total, 156 patients with sepsis were enrolled in our study, of which 41 had ALI and 32 had ARDS. miR-155 expression in plasma of patients with sepsis and ALI/ARDS was significantly higher than that of patients with sepsis but no ALI/ARDS. The miR-155 level in patients with sepsis and ALI/ARDS was positively correlated with interleukin (IL)-1β and tumor necrosis factor (TNF)-α levels and ALI/ARDS score, but negatively correlated with PaO2/FiO2. The AU-ROC of plasma miR-155 for diagnosis of sepsis with ALI/ARDS was 0.87, and plasma miR-155, IL-1β, and TNF-α had high sensitivity and specificity for the diagnosis of sepsis with ALI/ARDS. Conclusion miR-155 is highly expressed in plasma of patients with septic ALI/ARDS; it is positively correlated with lung function and can be used for early diagnosis.

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LL-37 Exacerbates Local Inflammation in Sepsis-Induced Acute Lung Injury by Preventing Mitochondrial DNA (mtDNA) Degradation-Induced Autophagy

Cited by 4 publications

References 24 publications

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Diagnostic value of miR-155 for acute lung injury/acute respiratory distress syndrome in patients with sepsis

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