Diagnostic value of miR-155 for acute lung injury/acute respiratory distress syndrome in patients with sepsis

Wang, Zhoufeng; Yang, Yong‐Lu; Fan, Huishou

doi:10.1177/0300060520943070

Cited by 13 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current baseline clinical information demonstrated that patients with ARDS had a longer duration of bypass than those without ARDS, revealing its potential association with the occurrence of ARDS. Existing studies indicate that using biomarkers can improve the early diagnosis and treatment of ARDS [ 27 ]. It can delay or even prevent the progression of high-risk patients to ARDS, which is the key to reducing the incidence and mortality of ARDS, and improving its diagnosis and treatment level [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Value and Mechanism of Long Non-Coding RNA UCA1 in Acute Respiratory Distress Syndrome Induced by Cardiopulmonary Bypass

Chen¹,

Xue²,

Fang³

et al. 2023

Heart, Lung and Circulation

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Clinical Value and Mechanism of Long Non-Coding RNA UCA1 in Acute Respiratory Distress Syndrome Induced by Cardiopulmonary Bypass

Chen¹,

Xue²,

Fang³

et al. 2023

Heart, Lung and Circulation

View full text Add to dashboard Cite

“…For example, the role of miR-146a and miR-155 in ARDS has been studied more clearly. In ARDS, the expression of miR-146a and miR-155 was increased, and they acted on IRAK-1/TRAF-6 and Socs1, respectively, and inhibited their expression to promote the ARDS inflammatory response [ 18 , 19 ]. A large number of similar studies have investigated the role of different microRNAs in ARDS, providing new ideas for the mechanism research, diagnosis, and treatment of ARDS.…”

Section: Discussionmentioning

confidence: 99%

Expression Level, Correlation, and Diagnostic Value of Serum miR-127 in Patients with Acute Respiratory Distress Syndrome

Lin

Jiang

Ren

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. To analyze the expression of miR-127 in the serum of patients with acute respiratory distress syndrome (ARDS) and to explore its correlation with the severity of ARDS patients and its value as a molecular marker for diagnosis of ARDS. Methods. 70 patients with ARDS admitted to our hospital from September 2017 to September 2019 were selected as the observation group, and 60 healthy persons with physical examination were collected as the control group. RT-PCR was used to detect the serum miR-127 levels of all subjects, and the serum miR-127 levels of the observation group and control group were compared. The oxygenation index (PaO2/FiO2) of ARDS patients was recorded and divided into three subgroups: mild group, moderate group, and severe group. Serum miR-127 levels of patients in the mild group, moderate group, and severe group were compared. Pearson correlation was used to analyze the relationship between serum miR-127 levels and the severity of ARDS patients. The receiver operating characteristic curve (ROC) was drawn, and the area under the ROC curve (AUC) was used to evaluate the diagnostic value of miR-127 in patients with ARDS. Results. The serum level of miR-127 (10.15 ± 1.03) in the observation group was significantly higher than that in the control group (3.09 ± 0.62). And in the three subgroups of mild, moderate, and severe, the serum miR-127 level in the moderate group (10.43 ± 0.71) and the severe group miR-127 level (11.05 ± 1.26) were significantly higher than those in the mild group level (9.38 ± 1.24). Pearson correlation analysis showed that the serum miR-127 level was negatively correlated with PaO2/FiO2 (r = −0.715, P < 0.05 ), that is, the serum miR-127 level was positively correlated with the severity of ARDS patients. The area under the curve (AUC) of the diagnostic value of serum miR-127 for ARDS was 0.732 (95% CI 0.607–0.858). When the optimal cutoff value was 0.380, the sensitivity was 59.1% and the specificity was 78.6%, which suggested that miR-127 can be used as a marker for ARDS diagnosis. Conclusion. There is an increase in miR-127 levels in the serum of ARDS patients. The serum miR-127 level is positively correlated with the severity of ARDS. The higher the level of miR-127, the worse the condition of ARDS, which is positively correlated with the severity of the condition. It suggests that the serum miR-127 level is an important indicator for evaluating the severity of ARDS patients. It can be used as a molecular marker for clinical diagnosis of ARDS.

show abstract

“…In a cohort of 156 sepsis patients of whom 41 with ALI and 32 with ARDS, miR-155 levels are higher in patients with ALI or ARDS, positively correlate with IL-1b and TNF, and negatively correlate with PaO2/FiO 2 ratio. miR-155 AUC for diagnosing sepsis with ALI/ARDS is 0.87 (253). A study comparing 218 critically ill patients (135 with sepsis) with 76 healthy controls shows that, in critically ill patients ≤ 65 years, high miR-155 levels are associated with increased survival.…”

Section: Biomarker Valuementioning

confidence: 99%

Modes of action and diagnostic value of miRNAs in sepsis

et al. 2022

View full text Add to dashboard Cite

Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting in life-threatening organ dysfunction. Sepsis is a major public health concern associated with one in five deaths worldwide. Sepsis is characterized by unbalanced inflammation and profound and sustained immunosuppression, increasing patient susceptibility to secondary infections and mortality. microRNAs (miRNAs) play a central role in the control of many biological processes, and deregulation of their expression has been linked to the development of oncological, cardiovascular, neurodegenerative and metabolic diseases. In this review, we discuss the role of miRNAs in sepsis pathophysiology. Overall, miRNAs are seen as promising biomarkers, and it has been proposed to develop miRNA-based therapies for sepsis. Yet, the picture is not so straightforward because of the versatile and dynamic features of miRNAs. Clearly, more research is needed to clarify the expression and role of miRNAs in sepsis, and to promote the use of miRNAs for sepsis management.

show abstract

Diagnostic value of miR-155 for acute lung injury/acute respiratory distress syndrome in patients with sepsis

Cited by 13 publications

References 21 publications

Clinical Value and Mechanism of Long Non-Coding RNA UCA1 in Acute Respiratory Distress Syndrome Induced by Cardiopulmonary Bypass

Clinical Value and Mechanism of Long Non-Coding RNA UCA1 in Acute Respiratory Distress Syndrome Induced by Cardiopulmonary Bypass

Expression Level, Correlation, and Diagnostic Value of Serum miR-127 in Patients with Acute Respiratory Distress Syndrome

Modes of action and diagnostic value of miRNAs in sepsis

Contact Info

Product

Resources

About