Abstract:All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage-associated molecular patterns (DAMPs). In addition to well-characterized DAMPs such as high-mobility group box 1 and adenosine triphosphate, studies on new classes of DAMPs have emerged. Here, we review recent reports of a new class of isoprenoid-derived DAMPs, including farnesyl pyrophosphate and geranylgeranyl py… Show more
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