Living Medication: Overview and Classification into Pharmaceutical Law

Heuer, Heike; Heuer, Lutz; Saalfrank, Valentin

doi:10.1007/978-3-642-19382-8_15

Cited by 2 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the current UMF classification is based on agar diffusion assays and correlates well with the MGO content [2], which seems somewhat contradictory to only physical effects. Hence, it seems that MHs show more or less regular pharmaceutical modes of action [21]. Similar views were raised by Kwakman and Zaat (2012) which found antibacterial activity against gram-positive bacteria (e.g., Bacillus subtilis) for compounds like bee defensin-1 and H 2 O 2 in honey produced by standardized process in greenhouses [2].…”

mentioning

confidence: 59%

“…Similar views were raised by Kwakman and Zaat (2012) which found antibacterial activity against gram-positive bacteria (e.g., Bacillus subtilis) for compounds like bee defensin-1 and H 2 O 2 in honey produced by standardized process in greenhouses [2]. Hence, the classification of antibacterial MH as a simple medical product is doubtful since a positive effect of these compounds on wound healing probably has to be considered [21] and adds another point to the discussion.…”

mentioning

confidence: 77%

“…However, according to the current state of knowledge, the main effect of Leptospermum honey for wound healing is at least to some extent (if not to the main extent) due to chemical compounds like MGO, H 2 O 2 , or bee defensin-1 [2,5,21]. In addition, the current UMF classification is based on agar diffusion assays and correlates well with the MGO content [2], which seems somewhat contradictory to only physical effects.…”

mentioning

confidence: 98%

“…Most of the analyzed MHs contained manuka honey. Its current mode of action as described in the certification procedure was based on osmotic effects implying a purely physical process [21].…”

mentioning

confidence: 99%

See 3 more Smart Citations

Detection and Quantification of Pyrrolizidine Alkaloids in Antibacterial Medical Honeys

Cramer

Beuerle

2012

Planta Med

View full text Add to dashboard Cite

In recent years, there has been an increasing interest in antibacterial honey for wound care ranging from minor abrasions and burns to leg ulcers and surgical wounds. On the other hand, several recent studies demonstrated that honey for human consumption was contaminated with natural occurring, plant derived pyrrolizidine alkaloids.1,2-Unsaturated pyrrolizidine alkaloids are a group of secondary plant metabolites that show developmental, hepato-, and geno-toxicity as well as carcinogenic effects in animal models and in in vitro test systems. Hence, it was of particular interest to analyze the pyrrolizidine alkaloid content of medical honeys intended for wound care.19 different medical honey samples and/or batches were analyzed by applying a recently established pyrrolizidine alkaloid sum parameter method. 1,2-Unsaturated pyrrolizidine alkaloids were converted into the common necin backbone structures and were analyzed and quantified by GC-MS in the selected ion monitoring mode.All but one medical honey analyzed were pyrrolizidine alkaloid positive. The results ranged from 10.6 µg retronecine equivalents per kg to 494.5 µg retronecine equivalents/kg medical honey. The average pyrrolizidine alkaloid content of all positive samples was 83.6 µg retronecine equivalents/kg medical honey (average of all samples was 79.3 µg retronecine equivalents/kg medical honey). The limit of detection was 2.0 µg retronecine equivalents/kg medical honey, while the limit of quantification was 6.0 µg retronecine equivalents/kg medical honey (S/N > 7/1).Based on the data presented here and considering the fact that medical honeys can be applied to open wounds, it seems reasonable to discuss the monitoring of 1,2-unsaturated pyrrolizidine alkaloids in honey intended for wound treatment.

show abstract

mentioning

confidence: 59%

mentioning

confidence: 77%

mentioning

confidence: 98%

mentioning

confidence: 99%

See 2 more Smart Citations

Detection and Quantification of Pyrrolizidine Alkaloids in Antibacterial Medical Honeys

Cramer

Beuerle

2012

Planta Med

View full text Add to dashboard Cite

show abstract

“…Da in der Tiermedizin bisher nur wenige Fallstudien vorliegen, können hier nur humanmedizinische Studien wiedergegeben werden. Nach Heuer et al [5] scheint es keine klinische Evidenz für Honigprodukte zur Heilung chronischer Wunden zu geben. Es wird empfohlen, die Anwendung von Manuka-Honig nur auf nicht chronische Wunden zu beschränken, wie sie z.…”

Section: Evidenzlageunclassified

Apitherapie – Honig in der Tiermedizin

Hauswirth¹

2014

Zeitschrift für Ganzheitliche Tiermedizin

View full text Add to dashboard Cite

show abstract

Living Medication: Overview and Classification into Pharmaceutical Law

Cited by 2 publications

References 34 publications

Detection and Quantification of Pyrrolizidine Alkaloids in Antibacterial Medical Honeys

Detection and Quantification of Pyrrolizidine Alkaloids in Antibacterial Medical Honeys

Apitherapie – Honig in der Tiermedizin

Contact Info

Product

Resources

About