Living Alone with Alzheimer’s Disease: Data from SveDem, the Swedish Dementia Registry

Čermáková, Pavla; Nelson, M. J.; Sečník, Juraj; García-Ptacek, Sara; Johnell, Kristina; Fastbom, Johan; Kilander, Lena; Winblad, Bengt; Eriksdotter, Maria; Religa, Dorota

doi:10.3233/jad-170102

Cited by 43 publications

(43 citation statements)

References 34 publications

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“…However, at older ages, women are more likely to live alone, which may in turn impact their number of hospitalizations and provision of dementia care. 50 Alternatively, differences in mortality rate may explain these results. Women have a higher life expectancy than men.…”

Section: Discussionmentioning

confidence: 99%

Thirty-year trends in dementia: a nationwide population study of Swedish inpatient records

Seblova¹,

Quiroga²,

Fors³

et al. 2018

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BackgroundThe continuous growth of the current dementia epidemic is contingent on the stability of age- and sex-specific trends over time. However, recent evidence suggests declining or stable trends. The aim of this study was to evaluate the real-world changes in the burden of dementia in older adults in Sweden from 1987 to 2016 by estimating age- and sex-specific incidence of dementia diagnosis in hospital inpatient records (dementia incidence). Differences in trends by sex, age, and educational levels were also examined.MethodsThe entire Swedish population aged 65 years and older was followed up from 1987 to 2016. Age-, sex-, and education-stratified dementia incidence rates for every follow-up year were estimated using the National Patient Register. Hazard ratio of receiving a dementia diagnosis in the inpatient records per 1 calendar year increase was estimated with discrete time logistic models with a complementary log–log link.ResultsAfter increase, especially in those >85 years of age, dementia incidence started to decrease in the last 5 years of the study period. After 2011, 1 calendar year increase was associated with lower hazard ratio of receiving a hospital diagnosis of dementia. The decrease had the highest magnitude in 70–74-year-olds (−5.5%), followed by 75–79-year-olds (−4.5%) and 80–84-year-olds (−4.0%). The decrease was present in both sexes and at all educational levels up to 90 years of age. Age was associated with the level of dementia incidence, and the trends differed by age group. Educational gradient was observed. University-educated older adults had the lowest rates of dementia. However, the trend over time did not substantially differ by sex or educational level.ConclusionOur results provide more evidence that dementia incidence may be declining. They also suggest that at least in hospitals, the number of new patients with dementia may decrease in the future.

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Section: Discussionmentioning

confidence: 99%

Thirty-year trends in dementia: a nationwide population study of Swedish inpatient records

Seblova¹,

Quiroga²,

Fors³

et al. 2018

CLEP

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“…We initially identified covariates based on previous literature as sociodemographic and health-related characteristics related to the risk of low cognitive performance and cognitive decline [1,5,[29][30][31][32][33][34]. Selected sociodemographic characteristics include age, gender (women vs. men), years of education, civil status (partner vs. no partner), employment status (currently working vs. not working), residence (urban vs. rural).…”

Section: Covariatesmentioning

confidence: 99%

Differences in cognitive performance and cognitive decline across European regions: a population-based prospective cohort study

Formánek¹,

Kågström²,

Winkler

et al. 2019

Eur. psychiatr.

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Background:A large variation in cognitive performance exists between European regions. However, it is unclear how older Europeans differ in the rate of cognitive decline.Methods:We analysed data from 22 181 individuals (54% women; median age 71) who participated in the Survey on Health, Ageing and Retirement in Europe. Cognition was measured using tests on verbal fluency, immediate and delayed recall. We used linear regression and linear mixed effects regression to examine regional differences in the level of cognitive performance and the rate of cognitive decline.Results:Scandinavians had the highest baseline cognitive scores (mean standardized overall cognitive score 0.3), followed by Western Europeans (mean 0.2), Central and Eastern Europeans (mean 0.1) and individuals from Mediterranean countries (mean -0.4). These differences persisted even after adjustment for sociodemographic and clinical characteristics. The annual cognitive decline in Scandinavia (0.59%) was approximately two times greater than in Western Europe (0.28%), Central and Eastern Europe (0.25%) and Mediterranean countries (0.23%).Discussion:There are substantial differences in cognitive performance as well as rates of cognitive decline among the elderly throughout European regions. This might be explained by differing levels of cognitive reserve.

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“…Information on clinical and social risk factors, as potential mediators in the association of SEP with cognition, was initially identified based on the literature [24][25][26][27][28][29][30] and availability in the SHARE dataset. From those, we chose variables that were associated with the composite cognitive score at the level of p < 0.05 in at least 4 waves, after adjustment for age, sex, and years of education.…”

Section: Covariatesmentioning

confidence: 99%

Socioeconomic position in childhood and cognitive aging in Europe

et al. 2018

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ObjectivesWe aimed to investigate whether socioeconomic position (SEP) in childhood has an effect on the level of cognitive performance and the rate of cognitive decline in older adults.MethodsWe performed a prospective cohort study of individuals enrolled in a multicenter population-based study, SHARE (Survey of Health, Ageing and Retirement in Europe). Interviews were conducted in 6 waves at approximately 2-year intervals and included examinations of cognitive performance (memory, verbal fluency, delayed recall) and measurements of childhood SEP (participants' household characteristics at the age of 10 years). We estimated the associations of SEP with the level of cognitive performance using linear regression and the relation to the rate of cognitive decline with mixed-effects models.ResultsThis study included 20,244 participants from 16 European countries (median age at baseline 71 years, 54% women). Adverse childhood SEP was associated with a lower level of baseline cognitive performance. This association was attenuated after adjustment for clinical and social risk factors but remained statistically significant. Childhood SEP was not related to the rate of cognitive decline.ConclusionsVariation in childhood SEP helps to explain differences in cognitive performance between older people, but not the rate of decline from their previous level of cognition. Strategies to protect cognitive aging should be applied early in life.

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Living Alone with Alzheimer’s Disease: Data from SveDem, the Swedish Dementia Registry

Cited by 43 publications

References 34 publications

Thirty-year trends in dementia: a nationwide population study of Swedish inpatient records

Thirty-year trends in dementia: a nationwide population study of Swedish inpatient records

Differences in cognitive performance and cognitive decline across European regions: a population-based prospective cohort study

Socioeconomic position in childhood and cognitive aging in Europe

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