Liver Morphologic Analysis in Perinatal Autopsies with Intrauterine Stress Liver Morphology in Perinatal Autopsies

Oliveira, Lívia Ferreira; Monteiro, Ana Paula Fernandes da Silva; Espíndula, Ana Paula; Pereira, Lívia Helena Morais; Rocha, Laura Penna; Guimarães, Camila Souza de Oliveira; Cavellani, Camila Lourencini; Castro, Eumênia Costa da Cunha; Corrêa, Rosana Rosa Miranda

doi:10.3109/15513815.2011.650505

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…This organ is enormously affected by intrauterine stress episodes, and morphological changes in this organ, such as steatosis, fibrosis, and foci of extramedullary erythropoiesis, are associated with perinatal death [6]. Altered hepatocytes change the pattern of CRP production, which in turn may serve as another marker of FIRS [7].…”

Section: Introductionmentioning

confidence: 99%

“…One study evaluating infants who went through different kinds of stresses, such as intrauterine anoxia, infections, and congenital malformations, demonstrated that these children presented higher birth weight than the expected for the GA as well as a series of alterations in different organs, including the liver [6]. Possibly, the expression of the markers of FIRS in the liver of autopsied children might explain the increased weight gain and these markers may undergo variations according to the cause of death.…”

Section: Introductionmentioning

confidence: 99%

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Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome

et al. 2014

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Anatomopathologic studies have failed to define the fetal inflammatory response syndrome (FIRS) as a cause of fetal death. Here, liver fragments of perinatal autopsies were collected at a university hospital from 1990 to 2009 and classified according to the cause of death, perinatal stress, and gestational age (GA) of the fetus. IL-6, TNF-α, and C-reactive protein (CRP) expression were immunostained, respectively, with primary antibody. Cases with congenital malformation, ascending infection, and perinatal anoxia showed increased IL-6, CRP, and TNF-α, respectively. Prematures presented higher expression of IL-6 whereas term births showed higher expression of CRP. Cases classified as acute stress presented higher expression of IL-6 and TNF-α and cases with chronic stress presented higher expression of CRP. GA correlated negatively with IL-6 and positively with CRP and TNF-α. Body weight correlated negatively with IL-6 and positively with CRP and TNF-α. Despite the diagnosis of FIRS being clinical and based on serum parameters, the findings in the current study allow the inference of FIRS diagnosis in the autopsied infants, based on an in situ liver analysis of these markers.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome

et al. 2014

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“…267 of the Ministry of Health of the Russian Federation (June 19, 2003). CAH was modeled by the placing of pregnant female rats (gestation days [14][15][16][17][18][19] into an altitude chamber and "ascent" to an altitude of 9000 m (pressure 224 mm Hg and oxygen saturation 42 mm Hg). Daily exposure lasted for 4 h. Parameters of liver tissue homeostasis in male offspring were measured on days 7 and 60 of postnatal development.…”

Section: Methodsmentioning

confidence: 99%

“…Chronic antenatal hypoxia (CAH) induces mitochondrial dysfunction in the fetal liver cells in experimental animals [10]. Signifi cant changes including local steatosis, fi brosis, and erythropoiesis loci were found during liver autopsy in newborn children exposed to CAH [14]. Hepatocyte apoptosis develops during oxygen hypoxia-oxygenation [11].…”

mentioning

confidence: 99%

Effects of Antenatal Hypoxia on the Parameters of Tissue Homeostasis in the Liver of Albino Rats

Pinaeva¹,

Лебедько

Yakovenko³

et al. 2014

Bull Exp Biol Med

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We studied age-dependent dynamics of some liver parameters in albino rats after antenatal hypoxia. A decrease in body weight, absolute liver weight in newborn and mature rats, and a reduction of relative weight of the liver in mature animals were observed under these conditions. It was found that antenatal hypoxia promotes a decrease in DNA-synthetic activity of hepatocytes, intensifies free radical processes in the liver of newborn rats, and reduces the number of nucleoli in hepatocytes. In mature animals, antenatal hypoxia was followed by a decrease in hepatocyte sizes and area of nucleoli, an increase in the number of binuclear cells relative to mononuclear cells, and a decrease in the number of nucleoli in hepatocyte nuclei. These data can reflect impairment of tissue homeostasis in the liver of mammals exposed to antenatal hypoxia.

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Perinatal Centrilobular Hepatic Necrosis in Giant Pandas (Ailuropoda Melanoleuca): A Retrospective Study

Roberts¹,

Murray²,

Love³

et al. 2021

Journal of Zoo and Wildlife Medicine

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Liver Morphologic Analysis in Perinatal Autopsies with Intrauterine Stress Liver Morphology in Perinatal Autopsies

Cited by 3 publications

References 15 publications

Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome

Interleukin-6 and C-Reactive Protein Are Overexpressed in the Liver of Perinatal Deaths Diagnosed with Fetal Inflammatory Response Syndrome

Effects of Antenatal Hypoxia on the Parameters of Tissue Homeostasis in the Liver of Albino Rats

Perinatal Centrilobular Hepatic Necrosis in Giant Pandas (Ailuropoda Melanoleuca): A Retrospective Study

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