Liver in ulcerative colitis: obstructive jaundice due to bile duct carcinoma.

Rankin, James G.; Skyring, A. P.; Goulston, S. J. M.

doi:10.1136/gut.7.5.433

Cited by 28 publications

(6 citation statements)

References 13 publications

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“…The only death (case 4) was due to hepatic duct carcinoma. This complication has been reported in ulcerative colitis with and without accompanying biliary disease (Stauffer et al, 1965;Rankin et al, 1966). It has been described in patients considered initially to have sclerosing cholangitis and subsequently within one to five years found to have an associated carcinoma.…”

Section: Discussionmentioning

confidence: 96%

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Primary sclerosing cholangitis, the biliary tree, and ulcerative colitis.

Thorpe¹,

Scheuer²,

Sherlock³

1967

Gut

158

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Section: Discussionmentioning

confidence: 96%

“…This may be associated with diseases other than ulcerative colitis, including retroperitoneal fibrosis and Riedel's struma (Bartholomew, Cain, Woolner, Utz, and Ferris, 1963). Ulcerative colitis may also be complicated by a carcinoma arising in a major bile duct (Stauffer, et al, 1965;Rankin, Skyring, and Goulston, 1966).…”

mentioning

confidence: 99%

Primary sclerosing cholangitis, the biliary tree, and ulcerative colitis.

Thorpe¹,

Scheuer²,

Sherlock³

1967

Gut

158

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“…According to Rankin et al (1966), the annual incidence in the population of Victoria, Australia, is about 0.0008% (Silverberg and Grant, 1970). It has a poor prognosis, and in the series reported by Ross et al (1972) the median survival time of those patients who died from their disease was less than 14 months from the time that symptoms first developed referable to the carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Parker and Kendall (1954) were the first to record this association but, more recently, a number ofauthors have suggested that carcinoma of the biliary tract may be a rare complication of chronic ulcerative colitis (Rankin, Skyring, and Goulston, 1966;Converse, Reagan, and DeCosse, 1971; Morowitz, Glagov, Dordal, and Kirsener, 1971). …”

mentioning

confidence: 99%

Ulcerative colitis and carcinoma of the proximal bile ducts

Ross¹,

Braasch²

1973

Gut

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SUMMARY In a review of 103 patients with carcinoma of the proximal bile ducts, eight patients were noted to have had ulcerative colitis also. This finding is strongly suggestive of a specific association between the two diseases. In three of the patients, carcinoma developed several years after proctocolectomy. Seven of the eight patients were significantly younger than the median age of the group as a whole, but no other apparent difference was noted between those with ulcerative colitis and the remainder of the group.During a review of the records of 103 patients with carcinoma of the proximal bile ducts seen at the Lahey Clinic Foundation during a 15-year period (Ross, Braasch, and Warren, 1972), it was noted that eight of these patients had, at some time, also had ulcerative colitis. Parker and Kendall (1954) were the first to record this association but, more recently, a number ofauthors have suggested that carcinoma of the biliary tract may be a rare complication of chronic ulcerative colitis (Rankin, Skyring, and Goulston, 1966;Converse, Reagan, and DeCosse, 1971;Morowitz, Glagov, Dordal, and Kirsener, 1971 occurred only four months after the onset of jaundice. At necropsy the patient was found to have a moderately well differentiated adenocarcinoma involving all the proximal bile ducts with direct spread into the liver. Metastases were discovered in the lymph nodes and in the porta hepatis. The presence of ascites and biliary cirrhosis was also recorded. CASE 2A 23-year-old woman first had symptoms of ulcerative colitis that were partially controlled during the next 20 years with unspecified medical treatment. However, at the age of 43, the patient underwent an emergency operation for a perforation of the colon, and a colostomy was constructed. Two years later, another perforation of the colon developed and this time an ileostomy with subtotal colectomy was carried out, leaving the rectum in place.At the age of46, gastrointestinal symptoms without jaundice developed that led to the performance of a laparotomy. A tumour, 3 cm, was found at the junction of the common hepatic and cystic ducts, and a biopsy showed it to be a poorly differentiated adenocarcinoma. The patient was referred to the Lahey Clinic where the presence of arthritis and a whitish discharge from the rectal stump were noted.

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“…(1965b) the effect of long-term therapy. Rankin, Skyring & Goulston (1966) reported the high incidence of bile duct carcinoma in patients with chronic ulcerative colitis. Thorpe, working with Professor Sheila Sherlock in London described the occurrence of sclerosing cholangitis in chronic ulcerative colitis .…”

Section: The Liver In Ulcerative Colitismentioning

confidence: 99%