Liver Enzymes

Abstract

Objective: To study the effect of breast cancer treatment on liver enzymes indiabetic and cardiac breast cancer females. Study Design: Cross-sectional type of study.Setting: Liaquat National Hospital Karachi. Period: January 2008 to January 2010. Patientsand Methods: Total 47 breast cancer patients. Out of these, 22 were diabetic and 25 werecardiac patients, visiting the oncology OPD of the hospital. Patients with metastasis to distantorgans were excluded from the study. Treatment was carried under the supervision of anoncologist. Samples were collected twice during the study. First sample was collected at diseasepresentation before starting any type of treatment and second time, sample was collected14 weeks after the last chemotherapy dose. Statistical analysis: Data was analyzed usingstatistical package (SPSS version 11.0). “Students t-test”and analysis of variance (ANOVA) wasused to analyze the means and standard deviations of quantitative/continuous variables. Inall statistical analysis p<0.05 was considered significant. Results: In all patient groups aftertreatment alkaline phosphatase was significantly high as compared to that before treatment(p<0.05) whereas alanine transaminase increased significantly without including Tamoxifenin the treatment. Variation pattern of liver enzyme was the same in both patient groups.Conclusions: Altered profile of liver enzyme was similar in both patient groups therefor thevariations cannot be attributed to hyperglycemia in diabetic females and the alterations in liverenzymes were attributed to liver damage by chemotherapy and fatty infiltration of liver inducedby Tamoxifen.