Liver disease associated with anti-liver-kidney microsome antibody in children

Maggiore, Giuseppe; Bernard, Olivier; Homberg, Jean‐Claude; Hadchouel, Michelle; Álvarez, Fernando; Hadchouel, P; Odièvre, M; Alagille, D

doi:10.1016/s0022-3476(86)80880-0

Cited by 119 publications

(95 citation statements)

References 13 publications

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“…Type 1 AIH is characterized by the presence of anti-nuclear antibodies (ANA) and/or antismooth muscle antibodies (SMA) and/or anti-soluble liver antigen (SLA) [6,7] . Type 2 AIH patients are defined by the presence of circulating anti-liver-kidney microsome antibodies (LKM1) and/or anti-liver cytosol 1 antibodies (LC1) [8,9] . Anti-LKM1 antibodies recognize the cytochrome P4502D6 (CYP2D6) [10] and anti-LC1 antibodies react against the formiminotransferase cyclodeaminase (FTCD) [9] .…”

Section: Autoimmune Hepatitis: An Overviewmentioning

confidence: 99%

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

Béland¹,

Lapierre²,

Álvarez³

2009

WJG

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Section: Autoimmune Hepatitis: An Overviewmentioning

confidence: 99%

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

Béland¹,

Lapierre²,

Álvarez³

2009

WJG

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“…This disease is considered a form of chronic hepatitis of etiology unknown that affects patients who have lost the immunologic tolerance to liver antigens (9) . The diagnostic is based in presence of clinic and laboratorial discovery and exclusion of others causes of chronic hepatic diseases (21) .…”

Section: Introductionmentioning

confidence: 99%

Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamins A, D and E

Saron

Godoy

Hessel

2009

Arq. Gastroenterol.

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-Context -Chronic liver disease may induce to malabsorption of lipids and fat-soluble vitamins, leading to injury of nutritional status. Objectives -To evaluate the nutritional status of pediatric-age patients with autoimmune hepatitis and biliary atresia related to serum levels of vitamins A, D and E and the disease severity. Methods -This controlled transverse study, evaluated the patients with autoimmune hepatitis and biliary atresia and a reference group paired by sex and age. The patients underwent anthropometric evaluation, alimentary inquiry and determination of serum levels of vitamins A, D and E by high performance liquid chromatography. The Mann-Whitney test, Spearman correlation coefficients and variance analysis (ANOVA) were utilized for data treatment, regarding significant difference if P<0.05. Results -The highest nutritional deficit was observed in patients with biliary atresia, mainly with cholestasis. The serum levels of vitamins A and E for the reference group changed as a function of age. The serum levels of vitamins A, D and E were higher in reference group than in patients with biliary atresia and autoimmune hepatitis together or separately. There were not difference in the serum levels of vitamins A, D and E between biliary atresia groups with cholestasis and without cholestasis. It was verified correlation between weight/age, triceps skinfold thickness, subscapular skinfold thickness, midarm circumference, midarm fat area values and vitamin A serum levels, as well as between all anthropometric indicators and vitamin E in patients with autoimmune hepatitis and biliary atresia. Conclusion -The patients with biliary atresia and cholestasis presented the highest nutritional injury. The patients with biliary atresia and autoimmune hepatitis presented lower serum levels of vitamins A, D and E that in control group. There is a directly proportional correlation between vitamin serum levels, mainly vitamin E, and all anthropometric variables of biliary atresia and autoimmune hepatitis groups.

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“…[1][2][3][4][5] In order to establish the diagnosis, it is necessary to rule out other causes of chronic liver disease. It is strongly associated with female individuals, hypergammaglobulinemia, other autoimmune disorders, with histocompatibility antigens (HLA B8, DR3, DR4) and with autoantibodies: antinuclear antibodies (ANA), anti-liver-kidney microsomal antibodies (type 1), anti-smooth muscle antibody (ASMA), antibody against soluble liver antigen, antibody against the human asialoglycoprotein receptor and antibodies against liverspecific membrane lipoprotein.…”

Section: Introductionmentioning

confidence: 99%

Hepatite auto-imune tipo 1 em crianças e adolescentes: avaliação da suspensão do tratamento imunossupressor

Ferreira

Roquete

Penna

et al. 2005

J. Pediatr. (Rio J.)

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Suggested citation: Ferreira AR, Roquete ML, Penna FJ, Toppa NH, de Castro LP. Type 1 autoimmune hepatitis in children and adolescents: assessment of immunosuppressive treatment withdrawal. J Pediatr (Rio J). 2005;81:343-8. AbstractObjective: To assess treatment withdrawal in children and adolescents with autoimmune hepatitis, with clinical and laboratory remission for a minimum period of 24 months, determining the relapse rate after treatment withdrawal.Method: This is a descriptive, retrospective and partially prospective study of 21 children and adolescents with type 1 autoimmune hepatitis treated at the Outpatient Division of Pediatric Hepatology, Teaching Hospital of Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil, between January 1986 and December 2001. Results:We assessed 54 patients and selected 21, of whom 19 were female subjects (90.5%), aged between 5.7 and 17.6 years (median = 13.8 years), with a mean follow-up of 5.1±2.4 years (median = 4.4 years) and an average clinical and laboratory remission of 4.1±1.5 years (median = 4.1 years). Out of the 21 patients studied, 10 (47.6%) manifested some inflammatory activity that prevented the discontinuation of treatment, which was withdrawn in 11 patients (52.4%). Out of these, six patients (54.5%) presented reactivation of the disease and five maintained clinical and laboratory remission with a mean follow-up of 4±1 years (median = 3.9 years). The time interval between discontinuation of treatment and reactivation of the disease ranged from 29 days to 40.3 months (median = 2.2 months). Conclusions:We observed a high relapse rate (54.5%) in this group of patients with autoimmune hepatitis, which was more frequent within the first 12 months after treatment withdrawal, in addition to a high number of patients that presented some degree of inflammatory activity despite the long period of clinical and laboratory remission.

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Liver disease associated with anti-liver-kidney microsome antibody in children

Cited by 119 publications

References 13 publications

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamins A, D and E

Hepatite auto-imune tipo 1 em crianças e adolescentes: avaliação da suspensão do tratamento imunossupressor

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