Liver ailments in pregnancy: our experience

Kohli, Uttara Aiyer; Seth, Atul; Singh, Sanjay; Mishra, Rajesh

doi:10.18203/2320-1770.ijrcog20170560

Cited by 4 publications

(14 citation statements)

References 5 publications

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“…In our study, preterm termination of pregnancy was done in 33.33% of patients. This is in accordance with the study result of Kohli et al ,[ 4 ] in which 33.56% of patients had preterm vaginal delivery (7.53%) or preterm lower segment cesarean section (LSCS; 26.03%). In a study by Dang et al ,[ 9 ] preterm termination of pregnancy was conducted in 19.14% of cases.…”

Section: Discussionsupporting

confidence: 93%

“…But in studies by Kohli et al . [ 4 ] and Tiwari et al ,[ 5 ] liver diseases were present in 2%–3% of all pregnancies. In our study, pregnancy-specific liver diseases were more common than preexisting liver diseases.…”

Section: Discussionmentioning

confidence: 99%

“…This is similar to the report of Kohli et al . [ 4 ] in which IHCP (35.62%) was more common. In the studies of Dang et al ,[ 9 ] García-Romero et al ,[ 3 ] Tiwari et al .…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 ] (48.93% vaginal deliveries) and Kohli et al . [ 4 ] (53.42% vaginal deliveries). In our study, preterm termination of pregnancy was done in 33.33% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…Low birth weight, that is, less than 2.5 kg, was seen in 43.58% of cases. In the study by Kohli et al ,[ 4 ] intrauterine death was found in 1.37% of patients and induced expulsion was done in 4.11% of patients. IUGR was seen in 39.29% of patients, and NICU admission was required in 19.29% of patients.…”

Section: Discussionmentioning

confidence: 99%

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Clinical spectrum and outcome of pregnancy with liver diseases – A prospective study

Bahadur

Mundhra

Kashibhatla

et al. 2022

Journal of Family Medicine and Primary Care

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Objective: Liver diseases constitute a family of diseases in pregnancy which are less often studied individually. Spectrum of liver diseases directly or indirectly related to pregnancy comprise 3% of all pregnancies. The biggest challenge is to arrive at a diagnosis in such cases. With this study we aimed to study the prevalence of different Liver diseases in pregnancy in our population and its effect on fetomaternal outcome. Material and Methods: This was a prospective observational study carried out from March 2018 to March 2020. A total of 184 pregnant women with diagnosis of some form of liver disease as evident from their symptoms, signs or biochemical investigations were included in study cohort. Result: Primigravida accounted for majority of study cohort (44.02%). Approximately 90.21% belonged to 20-35 yrs. Age group. Intrahepatic cholestasis of pregnancy (IHCP) was the most common liver ailment (66.84%) followed by viral hepatitis (10.32%), Hyperemesis gravidarum (7.06%) and HELLP syndrome (6.52%). There was one case of Acute fatty liver of pregnancy (0.54%), four cases of Pre-eclampsia with liver dysfunction (2.17%), seven cases of Jaundice in pregnancy (3.80%) and 3 cases of pre-existing liver diseases (1.63%). 5 cases (2.71%) of antepartum eclampsia, 5 cases (2.71%) of postpartum eclampsia and 1 case (0.54%) of post-partum HELLP was seen. 33.33% patients were delivered early by induction or caesarean section because of liver dysfunction.14.67% required blood or blood products transfusion.1.63% had postpartum hemorrhage.1.08% mothers required intensive care admissions. Neonatal outcome was poor with 6.41% being growth restricted, 9.61% premature, 8.97% were intrauterine dead fetuses, 2.56% had early neonatal deaths and 7.05% needed neonatal intensive care unit admissions. Conclusion: Timely admission, quick diagnosis and appropriate management of patients with liver diseases in pregnancy can make a significant difference in mortality and morbidity rates due to liver ailments in pregnancy.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

“…This is similar to the report of Kohli et al . [ 4 ] in which IHCP (35.62%) was more common. In the studies of Dang et al ,[ 9 ] García-Romero et al ,[ 3 ] Tiwari et al .…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 ] (48.93% vaginal deliveries) and Kohli et al . [ 4 ] (53.42% vaginal deliveries). In our study, preterm termination of pregnancy was done in 33.33% of patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical spectrum and outcome of pregnancy with liver diseases – A prospective study

Bahadur

Mundhra

Kashibhatla

et al. 2022

Journal of Family Medicine and Primary Care

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Evaluating the Utility of Liver Transaminases as Predictors of Feto-Maternal Outcome in Lieu of Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy: A Prospective Observational Study

Misra,

Singh,

Faruqi

et al. 2023

J Obstet Gynecol India

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Analysis of Causes of Hepatic Dysfunction in Obstetric Patients in India: A Systematic Review

Pandey¹,

Ahmed²,

Mishra³

et al. 2022

Indian Journal of Critical Care Medicine

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A bstract Background Epidemiology of liver disease in obstetric patients shows geographical variation depending upon the prevalence of preeclampsia, viral hepatitis, and tropical vector-borne diseases like malaria, leptospirosis, etc. We undertook the current systematic review to analyze the causes of hepatic dysfunction in obstetric patients in India and identify the gaps in the literature and reporting. Materials and methods We did a systematic review of studies reporting the causes of hepatic dysfunction in obstetric patients in India. A methodological quality assessment was done using a five-point questionnaire. Results A total of 21 studies qualified for evaluation. The rate of hepatic dysfunction among obstetric patients in India ranged from 0.15 to 3.3% with a mean and median rate of 1.49 and 0.93%, respectively. Preeclampsia/HELLP (mean = 36.0%, median = 31.4%, range: 3.6–83.8%) and viral hepatitis (mean = 34.1%, median = 35.5%, range: 5.1–61.8%) were the commonest causes of hepatic dysfunction. Other causes were intrahepatic cholestasis of pregnancy, acute fatty liver of pregnancy, tropical fever (malaria, leptospirosis, dengue, scrub typhus), etc. Maternal mortality ranged from 1.4 to 40% (mean = 12.6%, median = 10.0%) and perinatal mortality was between 16.4 and 38.70% (mean = 31.75%, median = 35.5%). Conclusion There is moderate quality evidence to show that preeclampsia/HELLP and viral hepatitis are the commonest causes of hepatic dysfunction in obstetric patients in India. How to cite this article Ahmed A, Saxena S, Pandey A, Mishra P, Azim A. Analysis of Causes of Hepatic Dysfunction in Obstetric Patients in India: A Systematic Review. Indian J Crit Care Med 2022;26(1):114–122.

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Liver ailments in pregnancy: our experience

Cited by 4 publications

References 5 publications

Clinical spectrum and outcome of pregnancy with liver diseases – A prospective study

Clinical spectrum and outcome of pregnancy with liver diseases – A prospective study

Evaluating the Utility of Liver Transaminases as Predictors of Feto-Maternal Outcome in Lieu of Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy: A Prospective Observational Study

Analysis of Causes of Hepatic Dysfunction in Obstetric Patients in India: A Systematic Review

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