Live cell therapy: historical aspects, mechanisms of action, safety and success stories

Abstract

Therapeutic applications of xenogeneic remedies and various forms of cell therapy can be traced back in history for many centuries. However its clinical application in conventional medicine started in the beginning of 20th century from Switzerland and Germany. Current paper highlights the milestones of development of live cell therapy as a paradigm of regenerative medicine, discusses mechanisms of its biological function, safety of cell therapy and offers a series of case reports.

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“…64,73,74 Stem cells are secreting a broad spectrum of paracrine factors, representing the components of the extracellular matrix, adhesion-and binding proteins, enzymes, growth factors, cytokines, and chemokines. 62,73,74 Promising potential has been shown by organ-specific cell extracts, the cell-free therapeutic, which can be derived and procured from xenogeneic tissue, possess a great reliability and reproducibility, easily manufactured, packaged and transported, can be lyophilized or shock-frozen, and do not need to match the donor-recipient compatibility to avoid immune reactions. 73,74 Moreover, compared to stem cells, cell extracts have advantages of a lower production time and cost, a higher shelf-life, and relatively easy storage method.…”

“…62,73,74 Promising potential has been shown by organ-specific cell extracts, the cell-free therapeutic, which can be derived and procured from xenogeneic tissue, possess a great reliability and reproducibility, easily manufactured, packaged and transported, can be lyophilized or shock-frozen, and do not need to match the donor-recipient compatibility to avoid immune reactions. 73,74 Moreover, compared to stem cells, cell extracts have advantages of a lower production time and cost, a higher shelf-life, and relatively easy storage method. 73,74 Organ-specific cell extracts can be harvested from various types of cells and different culture conditions, to ensure the organ-specificity maintained.…”

“…73,74 Moreover, compared to stem cells, cell extracts have advantages of a lower production time and cost, a higher shelf-life, and relatively easy storage method. 73,74 Organ-specific cell extracts can be harvested from various types of cells and different culture conditions, to ensure the organ-specificity maintained. The evaluation of biologically active ingredients from various tissue sources has been done, showing the differences in the composition, peptide characterization and clinical effects produced.…”