Lisinopril-Induced Acute Necrotizing Pancreatitis

Syed, Salman; Reyes, Jonathan Vincent M.; Baig, Muhammad A.

doi:10.7759/cureus.14642

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Of the common drugs associated with AP, ACE inhibitors have an even lower incidence of causality [5][6][7][8][9][10][11]. They are generally safe and have excellent tolerability with a low risk for adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Another Case of Lisinopril-Induced Acute Pancreatitis

Baum¹,

Walfish²,

Fenster³

et al. 2021

Cureus

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Lisinopril as a cause for acute drug-induced pancreatitis is an emerging phenomenon that due to its generally low-risk profile often goes unnoticed. The true incidence of drug-induced pancreatitis is unknown, probably because of its nonrecognition among differential diagnosis. Only a handful of lisinopril-induced pancreatitis has been discussed in the literature, and little epidemiological evidence exists to establish true causality. Additionally, many of these reports have been met with skepticism claiming that it is difficult to isolate a true cause since many of these patients had comorbidities or were concomitantly taking other medications that may have contributed to the pancreatitis. Here, we report a case in which a generally otherwise healthy patient presented with acute drug-induced pancreatitis caused by an angiotensin-converting enzyme (ACE) inhibitor taken eight weeks prior to the onset of symptoms. The drug was immediately stopped, and the patient recovered well, with no complications.

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Section: Discussionmentioning

confidence: 99%

Another Case of Lisinopril-Induced Acute Pancreatitis

Baum¹,

Walfish²,

Fenster³

et al. 2021

Cureus

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“…High ACE activity promotes angiotensin II production and bradykinin hydrolysis, leading to vasoconstriction and increased blood pressure [ 4 , 5 ]. Several chemical synthetic ACE inhibitors, such as captopril, enalaprilat, temocapril and lisinopril, have been used in hypertension treatment, but most of them produce side effects [ 6 , 7 , 8 ]. Thus, novel ACE inhibitors for developing anti-hypertension drugs are needed.…”

Section: Introductionmentioning

confidence: 99%

Anchoring of Polymer Loops on Enzyme-Immobilized Mesoporous ZIF-8 Enhances the Recognition Selectivity of Angiotensin-Converting Enzyme Inhibitory Peptides

et al. 2023

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Immobilized angiotensin-converting enzyme (ACE) is a promising material for the rapid screening of antihypertensive drugs, but the nonspecific adsorption is a serious problem in separation processes involving complex biological products. In this study, triblock copolymers with dopamine (DA) block as anchors and PEG block as the main body (DA-PEGx-DA) were attached to an immobilized ACE (ACE@mZIF-8/PDA, AmZP) surface via the “grafting to” strategy which endowed them with anti-nonspecific adsorption. The influence of DA-PEGx-DA chain length on nonspecific adsorption was confirmed. The excellent specificity and reusability of the obtained ACE@mZIF-8/PDA/DA-PEG5000-DA (AmZPP5000) was validated by screening two known ACE inhibitory peptides Val-Pro-Pro (VPP, competitive inhibitory peptides of ACE) and Gly-Met-Lys-Cys-Ala-Phe (GF-6, noncompetitive inhibitory peptides of ACE) from a mixture containing active and inactive compounds. These results demonstrate that anchored polymer loops are effective for high-recognition selectivity and AmZPP5000 is a promising compound for the efficient separation of ACE inhibitors in biological samples.

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