Although immune-related endocrinopathies are rarely fatal, they have a significant impact on patients' quality of life. Endocrinopathies are typically manageable with prompt recognition and treatment. But the subtle and non-specific manifestations make the diagnostic process a challenge. Standardized and practical screening tools can help in diagnosing these adverse events promptly, seeking specialized care if needed and may also aid in reducing healthcare-related costs.

Background and objectives: Road traffic crashes are reported to be the leading cause of maxillofacial fractures in developing countries. The large variability in reported incidence and etiology is due to a variety of contributing factors, including environmental, cultural and socioeconomic factors. The study aims at describing the patterns of maxillofacial fractures in road traffic crashes by clinical and radiological methods and to study the complications associated with these fractures. Materials and methods:The study included 100 road traffic crash patients with maxillofacial injuries. Patients were evaluated for any maxillofacial fracture by clinical assessment and, radiologically, using plain radiographs and computed tomography scan. Results:Midfacial skeleton was more prone to fractures. Isolated fractures of the maxilla was the commonest (58%) followed by nasal bone fractures (43%). Among the complex fractures, Le Fort type II was the commonest. Mandibular fractures were seen in 33% of the patients, parasymphysis being the commonest site. Majority of the patients had associated soft tissue injuries. The incidence of complications associated with maxillofacial fractures was 11%, malocclusion being the commonest. Conclusion:Maxillofacial fractures are commoner in the mobile population in the most productive age group, more so in two wheeler riders causing significant morbidity and mortality. Midface region is more prone to fractures and is most of the time associated with complications.

About 1 in 10 adults worldwide are estimated to have diabetes mellitus. They are at risk of developing life-threatening complications resulting in reduced quality of life, increased mortality and higher healthcare costs. The ability to prevent or delay type 2 diabetes mellitus (T2DM) by modifying some of its risk factors has been hypothesized for decades. The long and often gradual time-course of increasing dysglycemia prior to diabetes diagnosis suggests that interventions during that period could be effective in preventing T2DM. In addition to lifestyle modifications, certain drugs prevent or slow development of hyperglycemia. Recently, drugs used for obesity management were shown to prevent T2DM. In this review, we discuss various pharmacotherapeutic options for preventing T2DM.

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