Another Case of Lisinopril-Induced Acute Pancreatitis

Abstract

Lisinopril as a cause for acute drug-induced pancreatitis is an emerging phenomenon that due to its generally low-risk profile often goes unnoticed. The true incidence of drug-induced pancreatitis is unknown, probably because of its nonrecognition among differential diagnosis. Only a handful of lisinopril-induced pancreatitis has been discussed in the literature, and little epidemiological evidence exists to establish true causality. Additionally, many of these reports have been met with skepticism claiming that it is difficult to isolate a true cause since many of these patients had comorbidities or were concomitantly taking other medications that may have contributed to the pancreatitis. Here, we report a case in which a generally otherwise healthy patient presented with acute drug-induced pancreatitis caused by an angiotensin-converting enzyme (ACE) inhibitor taken eight weeks prior to the onset of symptoms. The drug was immediately stopped, and the patient recovered well, with no complications.

Mild Pancreatitis Induced by Linagliptin Revealed by a Medication Review

“…On initial follow-up after the acute emergency department visit, the patient had persistent symptoms, which prompted the search for other etiologies of pancreatitis. After reviewing all the medications the patient was taking, atorvastatin, lisinopril, and linagliptin were noted to be the three potential medications that could cause pancreatitis [2][3][4][7][8]. Although atorvastatin-induced pancreatitis can happen at any time, it was more common a few months after initiation [8].…”