Liquisolid Compacts: An Innovative Approach for Dissolution Enhancement

Abstract

The challenge faced by the majority of the pharmaceutical products is the poor solubility of the drug candidates which leads to low bioavailability. Liquisolid compact is one of the emerging techniques that enhances the dissolution of poorly water soluble drugs. Liquisolid system mentions to the formulation made by the transforming the liquid drug, either in the form of suspension or solution in non volatile solvents into a dry, non-sticky, free-flowing and compactable powder mixtures. This is achieved by mixing the suspension or solution of the drug with appropriate carriers and coating agents. The technology has the ability to increase aqueous solubility, rate of dissolution and absorption of poorly soluble drug by keeping it in molecularly dispersed form leading to its improved bioavailability when compared to conventional tablets. Liquisolid technology is the impending approach for enhancing the solubility of poorly water-soluble drug by adopting simple manufacturing process and low production cost.

HOMO-LUMO, NBO and Vibrational analysis of Sitagliptin by using DFT calculations and Experimental Study (FT-IR, FTRaman and UV-Visible Spectroscopies)

“…Liquid chromatographic determination of Sitagliptin either alone or in ternary mixture with metformin and Sitagliptin degradation product have been reported by El-Bagary et al [3].Review of Sitagliptin phosphate a novel treatment for type 2 diabetes was reported by Baptist Gallwitz et al [4]. Bio-analytical method development and validation of sitagliptin phosphate by RP-HPLC and its application to pharmacokinetic study was done by Anil Dubala et al [5]. Formulation and evaluation of sitagliptin phosphate gastro retentive tables were investigated by Krishna Keerthi et al [6].…”

Cinnarizine Liquid Solid Compacts: Preparation Evaluation

“…The different formulations were evaluated for the following properties such as angle of repose, bulk density, tapped density, Hausner's ratio, Carr's index [11].…”

Studies on Refined Liquisolid System for Simultaneous Improvement of Content Uniformity and Dissolution Profile of Glimepiride

“…or g/cm 3 . The weighed powder is placed in the measuring cylinder (100 ml) and the untapped volume is noted and the values obtained are placed in the following formula to calculate the bulk density [39].…”

“…All samples comprising 4 mg equivalent amount of GLD were made to dissolve in methanol and subjected to appropriate dilution. UV spectrophotometer at 250 nm wavelength was employed to estimate the content homogeneity of the samples [39].…”