Cinnarizine Liquid Solid Compacts: Preparation Evaluation

Sisinthy, Sreenivas Patro; Selladurai, Shubbaneswarei

doi:10.22159/ijap.2019v11i1.30109

Cited by 4 publications

(2 citation statements)

References 16 publications

(17 reference statements)

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“…The disintegrant (SSG), glidant (Talc), and binder (PVP K 30) was added to the freely flowable powder blend to obtain the liquisolid compact system Table 1. This powder mixture / liquisolid system was directly compressed in a rotary compression machine with 12 mm die size 15,16,17,18 .…”

Section: Methods Of Preparation For Liquisolid Tabletsmentioning

confidence: 99%

Untitled

2022

IJPSR

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Background: Hypertension is the most common disorder affecting different age groups of people. The increased blood pressure creates discomfort in the patients; these cardiovascular diseases are risky which can lead to "mortality and morbidity". Labetalol hydrochloride is an anti-hypertensive drug used to treat high blood pressure and Angina. These compounds possess less water solubility and low bioavailability (25%). Objective: The current study is aimed to develop Labetalol hydrochloride Liquisolid Tablets to enhance its solubility. Results: The in-vitro dissolution studies showed enhanced drug release at 98.43% with Avicel PH102 as carrier and 96.54% with Fujicalin as the carrier. Hence F3 with 98.43% drug release was considered the optimized formulation. The optimized formulation batch F3 was subjected to stability studies as per the ICH guidelines. There was no significant change observed. Conclusion:It can be concluded that labetalol hydrochloride was successfully incorporated as a liquisolid tablet by the direct compression method. The direct compression method employed was easy and can be widely used'. The powder blend of F3 containing avicel pH 102 as a carrier material showed excellent flow ability, liquid retention potential compared to the Fujicalin as a carrier. Hence F3 is considered optimized. The in-vitro drug release confirmed the enhanced drug release from the liquisolid tablets. The stability studies revealed the formulation was stable. INTRODUCTION:Hypertension is the most frequent condition that affects people of different ages. Hypertension is defined as a rise in blood pressure in the systemic arteries. The systolic blood pressure should not exceed 120 mm Hg, and the diastolic blood pressure should not exceed 80 mm Hg, which is considered normal.

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Section: Methods Of Preparation For Liquisolid Tabletsmentioning

confidence: 99%

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2022

IJPSR

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“…Diverse techniques such as conventional co-evaporation, solvent evaporation using rota-evaporator can be employed to confiscate the solvent [27]. Liquisolid Compact (LS) is a novel encouraging loom which could alter the rate of dissolution by improving wetting properties as well as the surface area of the drug by translating it into non-adherent, unrestricted surge with ease of compression of the powder meld [28,29]. LS compacts of poorly soluble drugs show a boost in the release of the drug because of the intensified surface area of the drug in soluble form in the non-volatile solvent will increase its aqueous solubility and reduction of contact angle for the drug particles [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Studies on Refined Liquisolid System for Simultaneous Improvement of Content Uniformity and Dissolution Profile of Glimepiride

2019

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Objective: To improve and compare dissolution contour of poorly soluble BCS Class II drug Glimepiride (GLD) by altering it to conventional solid dispersion (CSD), surface solid dispersion (SSD) and refined liquisolid system (RLS). Methods: The three formulations of GLD namely CSD, SSD and RLS were fabricated using the conventional methods by employing the suitable polymer and solvent system. These formulations were optimized on the basis of powder flow properties, FTIR, DSC and XRD analysis. All the optimized formulations were compared to the marketed formulation for content uniformity and dissolution rate. Results: The characteristic analysis of all the optimized formulations was obtained in the standard range. The average content uniformity (% age) of Marketed formulation, CSD, SSD and RLS found to be 88.28±0.721, 92.91±0.789, 95.98±0.478, 99.32±0.744 respectively. The in vitro dissolution rate (%age at 30 min time interval) fall in the range 59.78±0.036, 75.78±0.013, 93.11±0.019, 93.99±0.062 and 98.55±0.043 for pure drug, Marketed formulation, CSD, SSD and RLS respectively. All the analytical studies exhibited improved homogeneity/distribution of the drug in RLS. Conclusion: The RLS formulation presented sheer expansion in the content uniformity and dissolution contour of GLD at a minimal cost.

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Strategies for improving hydrophobic drugs solubility and bioavailability

Gupta,

Dakhole,

Jinnawar

et al. 2023

IJPCA

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Nowadays various drugs synthesized by various computational drug designs as well as various drugs have complex structure. Due to their complex structure, higher molecular weight which will increases solubility issues. Solubility is the most important and challenging task for researchers. Bioavailability and absorption of a drug depends on solubility of drug and thus we achieve pharmacological response. But poor aqueous solubility is a rate limiting step in bioavailability which made drug development more difficult. Drugs having low bioavailability require to be administered at a higher dose to achieve desired drug concentration in the systemic circulation and reach the target site. Thus, instead of getting desired effects drug produces side effects in the gastrointestinal tract. Hence, with the advancement of chemical science, the need of development of pharmaceutical technologies is also increasing. New techniques have been developed with a focus on enhancement of the solubility and oral bioavailability of poorly water-soluble drugs. The present review focuses on new technologies which are being used to resolve solubility issue of poorly soluble drugs which is the rate limiting step in bioavailability.

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Cinnarizine Liquid Solid Compacts: Preparation Evaluation

Cited by 4 publications

References 16 publications

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Studies on Refined Liquisolid System for Simultaneous Improvement of Content Uniformity and Dissolution Profile of Glimepiride

Strategies for improving hydrophobic drugs solubility and bioavailability

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