Liquid Marbles as Miniature Reactors for Chemical and Biological Applications

Nguyen, Nhat‐Khuong; Ooi, Chin Hong; Singha, Pradip; Jin, Jing; Sreejith, Kamalalayam Rajan; Phan, Hoang‐Phuong; Nguyen, Nam‐Trung

doi:10.3390/pr8070793

Cited by 67 publications

(58 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 1 ] LMs possess unique characters which cannot be attained by bare liquid droplets. [ 2–7 ] LMs show non‐wetting and non‐sticky natures, because the solid particle layer on their surfaces prevents the liquid core from contacting the supporting substrates, and they can move on solid and liquid surfaces without any trails. The particle layer can protect the inner liquid against contamination from outer world.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the inner liquid can be released by disruption of the LMs via application of external stimuli, such as pH, temperature, magnetic field, and mechanical stress. [ 5 ] Thanks to these characters, researches on LMs have yielded various promising applications such as carriers of materials in microfluidics, [ 6,8–12 ] sensors, [ 13–17 ] miniature reactors for chemical and biological reactions, [ 3,7,18–24 ] and powdered pressure‐sensitive adhesives. [ 25 ]…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Shape‐Designable Polyhedral Liquid Marbles/Plasticines Stabilized with Polymer Plates

Fujiwara

Geyer

Butt

et al. 2020

Adv Materials Inter

View full text Add to dashboard Cite

Polyhedral liquid marbles/plasticines are prepared using (sub)millimeter‐sized polymer plates as a stabilizer and water as an inner liquid. Precise control of size and shape can be successfully performed by tuning the size ratio of the water droplet and the plate, number of plates adsorbed to the droplet, coalescence (jointing) of multiple polyhedral liquid marbles/plasticines, and application of external mechanical stress. Thanks to interfacial jamming of the plates, plastic deformation of the liquid marbles/plasticines is achieved. The authors are able to fabricate liquid marbles/plasticines with various shapes including A–Z letters of alphabet. Liquid marble/plasticine with an aspect ratio exceeding 800, the largest aspect ratio ever reported, is also successfully prepared; the length of the liquid marble/plasticine exceeded 1.5 m. The liquid marbles can be picked up and be piled up on top of each other using tweezers or fingers. Furthermore, Janus‐type liquid marbles/plasticines with different curvatures and different stabilizers in a single liquid marble/plasticine can be fabricated by coalescence (jointing) of near‐spherical and cuboid liquid marbles/plasticines stabilized by plates with different sizes. An internal liquid flow from the near‐spherical liquid marble to the cuboid liquid marble/plasticine immediately after jointing is observed, making this system act as a micropump.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Shape‐Designable Polyhedral Liquid Marbles/Plasticines Stabilized with Polymer Plates

Fujiwara

Geyer

Butt

et al. 2020

Adv Materials Inter

View full text Add to dashboard Cite

show abstract

“…The low LOD and LOQ show that this method is sensitive enough to work with low concentration analyte. Since many studies of liquid marbles as microreactors usually utilise methylene blue and other chemicals that can be quantitatively determined using spectrophotometry, [65] digital imaging‐based method is a promising and cost‐effective alternative with high accuracy and reproducibility.…”

Section: Resultsmentioning

confidence: 99%

Digital Imaging‐based Colourimetry for Enzymatic Processes in Transparent Liquid Marbles

et al. 2020

Self Cite

View full text Add to dashboard Cite

Liquid marbles are a promising microreactor platform that recently attracts significant research interest owing to their ability to accommodate a wide range of micro reactions. However, the use of destructive and ex‐situ methods to monitor reactions impairs the potential of liquid‐marble‐based microreactors. This paper proposes a non‐destructive, in situ, and cost‐effective digital‐imaging‐based colourimetric monitoring method for transparent liquid marbles, using the enzymatic hydrolysis of starch as an illustrative example. The colourimetric reaction between starch and iodine produces a complex that exhibits a dark blue colour. We found that the absorbance of red channel of digital images showed a linear relationship with starch concentration with high sensitivity and repeatability. This digital‐imaging‐based colourimetric method was used to study the hydrolysis of starch by α‐amylase. The results show high accuracy and applicability of first‐order kinetics for this reaction. The demonstration of digital‐imaging‐based colourimetry indicates the potential of liquid marble‐based microreactors.

show abstract

“…In parallel, other studies demonstrated the successful use of 3D scaffold-free models, consisting of a small liquid droplet coated with a hydrophobic powder that eliminates the direct contact between the interior liquid and the external environment. The idea of encapsulating cells resuspended in a liquid with hydrophobic powder was derived from gall-dwelling aphids [ 67 ], where the honeydew waste secreted from the aphid is covered with a powdery wax before being rolled away, preventing it from drowning the insects. The first microbioreactor, also known as “liquid marble”, was reported by Aussillous et al, who covered a water droplet with hydrophobic microparticles [ 68 ].…”

Section: D Cell Culture Systemsmentioning

confidence: 99%

Current Advances in 3D Tissue and Organ Reconstruction

Pennarossa

Arcuri

Iorio

et al. 2021

IJMS

View full text Add to dashboard Cite

Bi-dimensional culture systems have represented the most used method to study cell biology outside the body for over a century. Although they convey useful information, such systems may lose tissue-specific architecture, biomechanical effectors, and biochemical cues deriving from the native extracellular matrix, with significant alterations in several cellular functions and processes. Notably, the introduction of three-dimensional (3D) platforms that are able to re-create in vitro the structures of the native tissue, have overcome some of these issues, since they better mimic the in vivo milieu and reduce the gap between the cell culture ambient and the tissue environment. 3D culture systems are currently used in a broad range of studies, from cancer and stem cell biology, to drug testing and discovery. Here, we describe the mechanisms used by cells to perceive and respond to biomechanical cues and the main signaling pathways involved. We provide an overall perspective of the most recent 3D technologies. Given the breadth of the subject, we concentrate on the use of hydrogels, bioreactors, 3D printing and bioprinting, nanofiber-based scaffolds, and preparation of a decellularized bio-matrix. In addition, we report the possibility to combine the use of 3D cultures with functionalized nanoparticles to obtain highly predictive in vitro models for use in the nanomedicine field.

show abstract

Liquid Marbles as Miniature Reactors for Chemical and Biological Applications

Cited by 67 publications

References 116 publications

Shape‐Designable Polyhedral Liquid Marbles/Plasticines Stabilized with Polymer Plates

Shape‐Designable Polyhedral Liquid Marbles/Plasticines Stabilized with Polymer Plates

Digital Imaging‐based Colourimetry for Enzymatic Processes in Transparent Liquid Marbles

Current Advances in 3D Tissue and Organ Reconstruction

Contact Info

Product

Resources

About