Liquid chromatograpic–mass spectrometric analysis of phenolics and free radical scavenging activity of rosemary extract from different raw material

Almela, L.; Sánchez-Muñoz, Blas; López, José Antonio Fernández; Roca, María; Rabe, Virginia

doi:10.1016/j.chroma.2006.02.056

Cited by 242 publications

(202 citation statements)

References 57 publications

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…Carnosic acid (CA) which is the major phenolic diterpene present in rosemary leaves ( Wellwood ET Al., 2004), and carnosol, both of which have been suggested to account for over 90% of the antioxidant properties of ISSN 2157-6076 2012 www.macrothink.org/jbls 51 rosemary extract ( Lemonica ET Al., 1996& Lo ET Al., 2001, and rosmarinic acid, rosmanol, a hydroxyl cinnamic acid ester, are the main antioxidant compounds present in rosemary. These compounds, together with other isoprenoids (sterol, isoprene, mono and diterpenes, tocopherols and carotenoids) are considered as anti-inflammatory agents ( Perez ET Al., 2007, Tawaha ET Al., 2007, Almela ET Al., 2006& Luis ET Al., 2007. Other compounds present in rosemary are the essential oils such as camphor, cineole, α-pinene, borneol which are largely used in traditional medicine, in perfumery and have also antimicrobial activity ( Marzouk ET Al., 2006, Weckessera ET Al., 2007, Gillij ET Al., 2008& Zaouali ET Al., 2008.…”

Section: Journal Of Biology and Life Sciencementioning

confidence: 99%

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Sheyab¹,

Abuharfeil²,

Salloum

et al. 2012

JBLS

View full text Add to dashboard Cite

The hypolipidemic activity of leaves of rosemary (Rosmarinus officinalis), a herbal plant was studied. Three groups of BALB/c mice were treated as following: the first group was fed with normal diet (sugar & water), the second group was fed with high cholesterol (HC) (2% by weight) and coconut oil (25% by weight), for 36 days, and the third group was fed with HC diet and given 100 mg/kg rosemary extract (10% w/v) during the last 15 days of treatment period. There was a significant decrease (P < 0.001) in plasma total cholesterol (TC)(-68.57%), low density lipoprotein (LDL) (-56.34%), and triglycerides (TG) (-182.61%). A significant increase in high density lipoprotein (HDL) (38.53%) was obtained in rosemary-fed mice compared to HC mice. In another experiment, the immunomodulatory activity of aqueous extract of R. officinalis was evaluated in BALB/c mice. Mice were treated with three doses of extract (10, 50, 100 mg/kg body weight) for 8 weeks. Humoral immunity against membrane proteins of sheep erythrocytes measured by ELISA showed that IgM (Immunoglobulin M) response significantly increased by 26.95%, 36.5%, 70.78% respectively, in mice fed with 10, 50, and 100 mg/kg of rosemary as compared to the control group (P < 0.05). IgG (Immunoglobulin G) response increased significantly at all antibody titers, in mice fed with rosemary at doses of 10, 50, and 100 mg/kg. Meanwhile, there was no significant different in IgM and IgG responses between 50 and 100 mg/kg (P > 0.05). On the other hand, concanavalin A-stimulated proliferation of spleen cells from mice fed with 100 mg rosemary extract was significantly higher by 57% than that of cells from the corresponding control animals.

show abstract

Section: Journal Of Biology and Life Sciencementioning

confidence: 99%

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Sheyab¹,

Abuharfeil²,

Salloum

et al. 2012

JBLS

View full text Add to dashboard Cite

show abstract

“…Rosmarinus officinalis (R. officinalis) has been used in the prevention of flap necrosis (5); it is known to exert antimicrobial (6-10), antioxidant (11)(12)(13)(14)(15)(16)(17)(18), anti-inflammatory (19,20), antifungal (6,9,10), antidiabetic (15), anticarcinogenic (13,19), antiplatelet (21), antimetastatic (13,19), antiproliferative (16) and antimutagenic (22) effects.…”

mentioning

confidence: 99%

Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps

et al. 2016

View full text Add to dashboard Cite

“…O alecrim (Rosmarinus officinalis Linné) é uma planta muito utilizada como flavorizante de alimentos devido às suas propriedades aromáticas. Também é utilizada como planta medicinal, apresentando comprovadas propriedades antioxidante, hepatoprotetora, antidiabética, antimicrobiana, antiproliferativa, dentre outras (ALMELA et al, 2006;SOUZA et al, 2008).…”

Section: Introductionunclassified

“…Sua atividade antioxidante está associada à presença de compostos fenólicos, como ácido carnósico e carnosol e a flavonoides (ALMELA et al, 2006;GENENA, 2005). Porém, esses compostos, principalmente o ácido carnósico e o carnosol, são susceptíveis à degradação (ZHANG et al, 2012).…”

Section: Introductionunclassified

Spray Drying De Dispersões Lipídicas Contendo Antioxidantes Naturais

Souza¹,

Baldim²,

Oliveira³

2015

Anais Do XXXVII Congresso Brasileiro De Sistemas Particulados

View full text Add to dashboard Cite

RESUMOO alecrim (Rosmarinus officinalis) é uma fonte de compostos antioxidantes que podem contribuir na prevenção de doenças degenerativas (câncer e diabetes). No entanto, instabilidades como a auto-oxidação e degradação desses compostos reduzem sua eficácia. Portanto, existe a necessidade de desenvolver sistemas que melhorem a estabilidade de seus compostos bioativos. Os carreadores lipídicos são efetivos sistemas de encapsulação, apresentando facilidade de preparo, escalonamento e baixa toxicidade. O objetivo deste trabalho foi produzir sistemas micro e nanoestruturados através do emprego de carreadores lipídicos contendo extrato liofilizado de alecrim e avaliar a influência dos tipos e proporções de adjuvantes na secagem por spray dryer. Os parâmetros de secagem foram temperatura do ar de entrada: 100°C, vazão do ar de secagem: 60 m 3 /h, vazão de alimentação: 4 g/min e pressão do ar de atomização de 3 kgf/cm 2 . O rendimento do processo manteve-se entre 28 e 67%, com teor de umidade abaixo de 6% e atividade de água de 0,3. A análise de tamanho de partícula forneceu valores em torno de 900 nm, sendo os pós obtidos classificados como de baixo fluxo.

show abstract

Liquid chromatograpic–mass spectrometric analysis of phenolics and free radical scavenging activity of rosemary extract from different raw material

Cited by 242 publications

References 57 publications

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps

Spray Drying De Dispersões Lipídicas Contendo Antioxidantes Naturais

Contact Info

Product

Resources

About