Use of Systemic Rosmarinus Officinalis to Enhance the Survival of Random-Pattern Skin Flaps

İnce, Bilsev; Bilgen, Fatma; Gundeslioglu, Ozlem; Dadacı, Mehmet; Kozacıoğlu, Sümeyye

doi:10.5152/balkanmedj.2016.150981

Cited by 7 publications

(8 citation statements)

References 23 publications

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“…Although the average ratio of the viable surface area in the control groups was similar in previous studies and in our study, it was different in the experimental groups. The average ratio of viable surface area was 67.68% and 96% in previous studies (5,6). However, in our study, the highest average ratio of viable surface area was 74% in group VIII, in which all 3 components were given.…”

Section: Discussioncontrasting

confidence: 74%

“…When these studies are considered together, the bioavailability of RO is the highest when administered orally (5,6). Thus, oral administration was used in our study.…”

Section: Discussionmentioning

confidence: 99%

“…We performed flap elevation after 1 week of treatment because the average ratio of the viable surface area to the total flap area was found to be the highest in previous studies investigating the effects of RO on flap viability (5,6). Flap elevation after 1 week of treatment can increase flap survival in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies investigating the effects of RO on the survival of skin flaps, the viable surface areas of ROtreated flaps were reported to be significantly greater in all treated groups than that in control groups (5,6). The authors claimed that, in addition to antiinflammatory and antioxidant effects, RO had vasodilatory effects that contributed to increased flap survival.…”

Section: Introductionmentioning

confidence: 99%

“…Rosmarinus officinalis (RO) is the one of the agents that have been used systemically and topically in the prevention of flap necrosis (5,6). RO has antimicrobial (7-10), antioxidant (11)(12)(13)(14)(15)(16)(17)(18), antiinflammatory (19,20), antifungal (7,9,10), antidiabetic (15), anticarcinogenic (13,19), antiplatelet (21), antimetastatic (13,19), antiproliferative (16), and antimutagenic (22) effects.…”

Section: Introductionmentioning

confidence: 99%

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Effect of cineole, alpha-pinene, and camphor on survivability of skin flaps

2018

Turk J Med Sci

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Background/aim: The aim of this study was to determine the specific component of Rosmarinus officinalis (RO) responsible for increased flap survival and how RO displays its efficacy. Materials and methods: Rectangular random-pattern flaps were elevated from the back of each rat. Group I was the control group. In group II 0.1 mL of cineole, in group III 0.1 mL of alpha-pinene, in group IV 0.1 mL of camphor, in group V 0.1 mL each of alpha-pinene and cineole, in group VI 0.1 mL each of alpha-pinene and camphor, in group VII 0.1 mL each of cineole and camphor, and in group VIII, 0.1 mL each of alpha-pinene, cineole, and camphor was orally administered once a day before surgery. The luminal area of the largest blood vessel in the proximal flap was measured. Interleukin-1, tumor necrosis factor alpha, thiobarbituric acid reactive substances, and vascular endothelial growth factor values were measured. Results: The mean percentage of the viable surface area was significantly greater in groups VIII, III, and V. The mean percentage of vessel diameter was significantly greater in groups V, VIII, and VII. Conclusion: We suggest that alpha-pinene and cineole were the components of RO that were responsible for increased flap survival. The most effective of feature of RO was the antiinflammatory effects.

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Section: Discussioncontrasting

confidence: 74%

“…When these studies are considered together, the bioavailability of RO is the highest when administered orally (5,6). Thus, oral administration was used in our study.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%