Abstract:Desoxo-narchinol A is one of the major active constituents from Nardostachys jatamansi, which has been reported to possess various pharmacological activities, including anti-inflammatory, antioxidant, and anticonvulsant activity. A simple and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of desoxo-narchinol A in two different biological matrices, i.e., rat plasma and mouse plasma, using sildenafil as an internal standard (IS). The … Show more
“…This phenomenon was almost the same as that reported in a previous study, 28,35,36 and it may have been caused by a variety of factors, such as fractionated gastric emptying, enterohepatic circulation and separated "absorption windows". [37][38][39] However, the mechanism of this phenomenon in the pharmacokinetic study needs further detailed investigation. All in all, these results should drive further studies of eriocitrin and promote research into developing efficacy in clinical therapeutic studies.…”
Eriocitrin is one of the major active constituents of lemon fruit, and it possesses strong antioxidant, lipid-lowering, anticancer and anti-inflammatory activities and has long been used in food, beverages and wine.
“…This phenomenon was almost the same as that reported in a previous study, 28,35,36 and it may have been caused by a variety of factors, such as fractionated gastric emptying, enterohepatic circulation and separated "absorption windows". [37][38][39] However, the mechanism of this phenomenon in the pharmacokinetic study needs further detailed investigation. All in all, these results should drive further studies of eriocitrin and promote research into developing efficacy in clinical therapeutic studies.…”
Eriocitrin is one of the major active constituents of lemon fruit, and it possesses strong antioxidant, lipid-lowering, anticancer and anti-inflammatory activities and has long been used in food, beverages and wine.
“…The absorbed drug superimposed in the blood, and the double peak phenomenon of the drug-time curve appeared. 38,39 In Fig. 3 The concentration-time curve of plasma eupatorin in rats after single oral medication (50 mg kg À1 ).…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.